CAM-alternatívny zvierací model pre štúdium biomateriálov

Tissue engineering is a combination of cells, biochemical, physico-chemical factors and biomaterials to improve or replace of biological functions. Chorioallantoic membrane of the chick embryo /or quail embryo is an interesting, recognized a very suitable animal model for studying biocompatibility of tested biomaterial by ex ovo or in ovo method. This is a low-tech method, which makes it possible to continuously monitor the experiment, to easily and quickly obtain results, and to evaluate them in a short time. The project is focused on the study of angiogenesis of biomaterials implanted on the CAM using macroscopic, histological, immunohistochemical and molecular-biological methods. Modern and advanced scientific approach of developing new biomaterials is characterized by tight multidisciplinary connection of biomaterial engineering methods and in vivo studied systems that with high probability allow assess their suitability as a models for testing biomaterials.