Regenerácia defektov kĺbovej chrupky pomocou inovatívnych biomateriálov

The project is focused on pre-clinical in vivo testing of innovative biomaterials using the animal model. The structure of composites is original and unique, they contain a polymeric component of the polysaccharide type and biocement. In this arrangement, it will be helpful to analyze in the animal model healing of joint cartilage defects and in-vivo interfaces linking the original cartilage tissue to the implant, characterizing the formation of the individual components of the articular cartilage, and understanding the gradual transformation of the composite chondral implant into the cartilage. Monitoring of the cartilage defect healing will provide by imaging methods RTG, CT, MR, histological, immunohistochemical, or molecular methods. The in vivo biomaterial test procedure used in the present project, represents the multidisciplinary connection of biomaterial engineering and in vivo testing of studied systems that with high probability allow to assess their suitability for the using in human medicine.