ProjectsUtilization of biocements in cartilage and hard tissue regeneration

Utilization of biocements in cartilage and hard tissue regeneration

Identifier	1/0336/20
Funding scheme	Scientific grant agency (Ministry of education, science, research and sport of the Slovak Republic)
Principal investigator at UVLF	Šimaiová Veronika, MVDr., PhD.
Project duration	01.01.2020 – 31.12.2023

The project is focused on pre-clinical in vivo testing of innovative biomaterials using the animal model. The structure of composites is original and unique, containing the biocement component. In this arrangement, it will be helpful to analyze in the pig animal model healing of joint cartilage and hard tissue defects, characterizing the formation of the individual components of the articular cartilage and bone and understanding the gradual transformation of the composite implant. Monitoring of the cartilage and hard tissue defect healing will provide by imaging methods RTG, CT, MR, histological, immunohistochemical or molecular methods. The in vivo biomaterial test procedure used in the present project represents the multidisciplinary connection of biomaterial engineering and in vivo testing of studied systems, that with high probability allow to assess their suitability for the using in human medicine.

Partners

University of Veterinary Medicine and Pharmacy in Košice (Project coordinator)
Institute of Materials Research of the Slovak Academy of Sciences

Project outputs

KREŠÁKOVÁ, Lenka - DANKO, Ján - VDOVIAKOVÁ, Katarína - MEDVECKÝ, Ľubomír - ŽERT, Zdeněk - PETROVOVÁ, Eva - VARGA, Maroš - ŠPAKOVSKÁ, Tatiana - PRIBULA, Jozef - GAŠPÁREK, Miroslav - GIRETOVÁ, Mária - ŠTULAJTEROVÁ, Radoslava - KOĽVEK, Filip - ANDREJČÁKOVÁ, Zuzana - ŠIMAIOVÁ, Veronika - KADAŠI, Marián - VRABEC, Vladimír - TÓTH, Teodor - HURA, Vladimír. In vivo study of osteochondral defect regeneration using innovative composite calcium phosphate biocement in a sheep model. In: Materials. 2021. ISSN 1996-1944, Vol. 14, no. 16 (2021), art. no. 4471, p. [1-21]. (2021: 3.748 - IF, 128 - H-index, 4.042 - IF 5y, 0.604 - SJR, Q2 - SJR Best Q, Q1 - JCR Best Q, 0.541 - ABDC).
Publication details
VDOVIAKOVÁ, Katarína - DANKO, Ján - KREŠÁKOVÁ, Lenka - ŠIMAIOVÁ, Veronika - PETROVOVÁ, Eva - NOVOTNÝ, Jaroslav - ŽERT, Zdeněk - KOĽVEK, Filip - VALOCKÝ, Igor - VARGA, Maroš - ŠPAKOVSKÁ, Tatiana - PRIBULA, Jozef - GAŠPÁREK, Miroslav - GIRETOVÁ, Mária - ŠTULAJTEROVÁ, Radoslava - MEDVECKÝ, Ľubomír. The morphological, clinical and radiological outputs of the preclinical study after treatment of the osteochondral lesions in the porcine knee model using implantation of scaffold based on the of calcium phosphate biocement. In: Frontiers in Materials. 2021. ISSN 2296-8016, Vol. 8, no. (2021), art. no. 746800, p. [1-14]. (2020: 3.515 - IF, 3.536 - IF 5y, 0.658 - ABDC).
Publication details