Cytokins and expression of receptors on immunocompetent cells in acute phase of salmonellosis in chickens and hens

Salmonella enterica is one of the major causes of food-borne bacterial gastroenteritis worldwide.The majority of human salmonellosis are caused by Salmonella enterica serovar Enteritidis or serovar Typhimurium.Infection by Salmonella enterica induces expression of pro inflammatory cytokines and later changes in subpopullation of immunocompetent cells in intestinal epithelium and peripheral blood cells.It is supposed that expression of pro inflammatory cytokines can be different in new born chicks that is innon mature immune system and adult hens with mature immune system.Expression ofcytokins can be modulated by aplication of probiotic mainly in chickens.Determination of the level of pro inflammatory cytokins in chickens and adult hens under the modulation of the level of cytokines by probiotics can give as new information about interaction salmonella-host. Increased understandig of immune and pathological mechanisms at molecular and cellular levels can help to develop novel strategies.