ProjectsOptimization of the therapeutic efficacy of FMT using a natural additive in the treatment of nonspecific intestinal inflammation induced in a PGF animal model of acute UC.

Optimization of the therapeutic efficacy of FMT using a natural additive in the treatment of nonspecific intestinal inflammation induced in a PGF animal model of acute UC.

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Identifier	1/0389/25
Funding scheme	Scientific grant agency (Ministry of education, science, research and sport of the Slovak Republic)
Principal investigator at UVLF	Gancarčíková Soňa, MVDr., PhD.
Name of the project’s principal investigator	Vlasta Demečková RNDr., PhD., univ.docentka
Project duration	01.01.2025 – 31.12.2028

Inflammatory bowel disease (IBD) is a chronic multifactorial inflammation of the gastrointestinal tract (GIT) requiring lifelong treatment. Currently, there are several therapeutic options, but the problem is the progressive resistance to treatment or its total failure. Moreover, all approved therapies are aimed at the over-activated immune response rather than at the modulation of the intestinal microbiome, despite the fact that clinical data indicate that dysbiosis plays a key role in the pathogenesis of IBD. In response to this fact, research has been launched into therapies aimed at re-establishing intestinal normobiosis. Fecal microbiota transplantation (FMT) is the process of introducing biological material containing microorganisms from a healthy donor into the GIT of a patient in order to restore intestinal homeostasis. The presented project focuses on investigating the effect of FMT and its modified form enriched with a natural additive on the pathogenesis of acute ulcerative colitis using the PGF mouse model.

Partners

Pavol Jozef Šafárik University in Košice (Project coordinator)
University of Veterinary Medicine and Pharmacy in Košice
University of Veterinary Medicine and Pharmacy in Košice

Project outputs

BLAŽÍČKOVÁ, Laura. Vplyv transplantácie fekálnej mikrobioty na zmeny v dynamike metabolickej aktivity črevnej mikrobioty u animálneho modelu s indukciou ulceróznej kolitídy : diplomová práca. Košice : UVLF 2025. 60 l + CD-ROM.
Publication details
LAUKO, Stanislav - GANCARČÍKOVÁ, Soňa - HAJDUČKOVÁ, Vanda - JANIČKO, Martin - HRČKOVÁ, Gabriela - HIJOVÁ, Emília - KVAKOVÁ, Monika - GULAŠOVÁ, Zuzana - STROJNÝ, Ladislav - AMBRO, Ľuboš - HERTELYOVÁ, Zdenka - MUDROŇOVÁ, Dagmar - DEMEČKOVÁ, Vlasta - ADAMKOVÁ, Petra - ANDREJČÁKOVÁ, Zuzana - RYNIKOVÁ, Mária - KAMLÁROVÁ, Anna - ŠTOFILOVÁ, Jana - SPIŠÁKOVÁ, Daniela - SOPKOVÁ, Drahomíra - BERTKOVÁ, Izabela. The impact of dysbiotic microbiota obtained from patient with ulcerative colitis on the pathogenesis of UC by utilizing animal model [Vplyv dysbiotickej mikrobioty získanej od pacienta s ulceróznou kolitídou na patogenézu UC využitím animálneho modelu]. In: Workshop for young Scientists "Hot Topics in Microbiology 2025". Hot Topics in Microbiology 2025 : Workshop for young Scientist. Book of Abstracts. Bratislava : Univerzita Komenského, 2025. ISBN 978-80-973411-7-6, s. 23.
Publication details
SPIŠÁKOVÁ, Daniela - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - JANIČKO, Martin - HAJDUČKOVÁ, Vanda - DEMEČKOVÁ, Vlasta - RYNIKOVÁ, Mária - ADAMKOVÁ, Petra - MUDROŇOVÁ, Dagmar - BERTKOVÁ, Izabela. Evaluation of bacterial composition and viability of faecal microbiota transplant: comparative analysis of its frozen and lyophilized form [Evaluation of bacterial composition and viability of faecal microbiota transplant: comparative analysis of its frozen and lyophilized form]. In: Workshop for young Scientists "Hot Topics in Microbiology 2025". Hot Topics in Microbiology 2025 : Workshop for young Scientist. Book of Abstracts. Bratislava : Univerzita Komenského, 2025. ISBN 978-80-973411-7-6, s. 27.
Publication details
LAUKO, Stanislav - GANCARČÍKOVÁ, Soňa - HAJDUČKOVÁ, Vanda - JANIČKO, Martin - HRČKOVÁ, Gabriela - HIJOVÁ, Emília - KVAKOVÁ, Monika - GUĽAŠOVÁ, Zuzana - STROJNÝ, Ladislav - AMBRO, Ľuboš - HERTELYOVÁ, Zdenka - MUDROŇOVÁ, Dagmar - DEMEČKOVÁ, Vlasta - ADAMKOVÁ, Petra - ANDREJČÁKOVÁ, Zuzana - RYNIKOVÁ, Mária - KAMLÁROVÁ, Anna - ŠTOFILOVÁ, Jana - SPIŠÁKOVÁ, Daniela - BERTKOVÁ, Izabela. Inovatívny animálny model indukcie akútnej ulceróznej kolitídy prostredníctvom FMT od pacienta s diagnostikovanou UC. In: Mikrobiológia okolo nás 2025. Mikrobiológia okolo nás 2025 : Zborník abstraktov. 1. vyd. Bratislava : Československá spoločnosť mikrobiologická, 2025. ISBN 978-80-973411-8-3, s. 14.
Publication details
RYNIKOVÁ, Mária - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - MUDROŇOVÁ, Dagmar - JANIČKO, Martin - HAJDUČKOVÁ, Vanda - ADAMKOVÁ, Petra - DEMEČKOVÁ, Vlasta. Mikrobiómom vyvolaná disrupcia črevnej epitelovej bariéry ako potenciálny spúšťač chronického zápalu v ulceróznej kolitíde. In: Interaktívna Konferencia Mladých Vedcov 2025. Interaktívna Konferencia Mladých Vedcov 2025. Bratislava : Občianske združenie Preveda, 2025. ISBN 978-80-99936-86-8, s.
Publication details
RYNIKOVÁ, Mária - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - MUDROŇOVÁ, Dagmar - HAJDUČKOVÁ, Vanda - ADAMKOVÁ, Petra - DEMEČKOVÁ, Vlasta. Harnessing the gut microbiome to optimize animal models of ulcerative colitis: Insights from a multi-omic approach. In: Targeting Microbiota : Padova : International Society of Microbiota, 2025. s. 118.
Publication details
DEMEČKOVÁ, Vlasta - RYNIKOVÁ, Mária - ADAMKOVÁ, Petra - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - JANIČKO, Martin - HAJDUČKOVÁ, Vanda. Dual triggers, one therapy: Structural-functional analysis of fecal transplantation in ulcerative colitis. In: Targeting Microbiota : Padova : International Society of Microbiota, 2025. s. 72.
Publication details
LAUKO, Stanislav - GANCARČÍKOVÁ, Soňa - HAJDUČKOVÁ, Vanda - JANIČKO, Martin - HRČKOVÁ, Gabriela - HIJOVÁ, Emília - KVAKOVÁ, Monika - GULAŠOVÁ, Zuzana - STROJNÝ, Ladislav - AMBRO, Ľuboš - HERTELYOVÁ, Zdenka - DEMEČKOVÁ, Vlasta - ADAMKOVÁ, Petra - ANDREJČÁKOVÁ, Zuzana - RYNIKOVÁ, Mária - KAMLÁROVÁ, Anna - ŠTOFILOVÁ, Jana - SPIŠÁKOVÁ, Daniela - BERTKOVÁ, Izabela. Obtaining a combined animal model of acute UC through exposure to DSS and microbiota from a patient with UC. In: Targeting Microbiota : Padova : International Society of Microbiota, 2025. s. 93.
Publication details
RYNIKOVÁ, Mária - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - MUDROŇOVÁ, Dagmar - ADAMKOVÁ, Petra - JANIČKO, Martin - DEMEČKOVÁ, Vlasta. Exploring new animal models of ulcerative colitis: evaluating chemical and patient-derived microbial triggers to advance translational relevance. In: Laboratory animal research. 2026. ISSN 1738-6055, Vol. 42, no. 1 (2026), art. no. 21, p. [1-22].
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