The influence of intestinal mucosal immunity and the intestinal microbiome on the central nervous system in neurodegenerative disease - an animal model

The gut microbiota is emerging as a key regulator of many disease states, and its dysregulation is implicated in the pathogenesis of several gastrointestinal and extraintestinal disorders. Recently, alterations in the gut microbiota have been linked to Alzheimer\\\'s disease (AD) neurodegeneration through an increasingly defined \\\"brain-gut microbiota\\\" axis. This opens up the possibility of novel therapeutic options for this disease based on the gut microbiota and immunity. Several studies have shown that probiotic bacteria can modulate the colonization of the gut microbiota by beneficial microorganisms, regulate the state of gut dysbiosis, and consequently influence the gut-brain axis.