Microbiome modulators for maintaining dermal health in animals

The skin - the largest organ of the body - harbors a wide variety of microbes that, together with their genetic information and host interactions, form the skin microbiome. Many of these microorganisms are harmless and in some cases even provide vital functions such as protection against invasion by the pathogenic organisms, modulation of the function of the skin\\\\\\\'s immune system, as well as acceleration of healing and reduction of inflammation in case of injury. Dysbiosis refers to the lack of balance among microbial communities within certain areas of the body that may lead to the onset or progression of diseases and is the focus of current scientific research. The goal is to find innovative methods to maintain the skin\\\\\\\'s microbial homeostasis and to avoid the use of antimicrobial treatment, which except the eradication of pathogens causing skin disease, also reduces beneficial part of the microbiome. Therefore, the intention of the project is to find supplementary therapeutic agent to strictly antibacterial agents in the form of an antibiotic-sensitive, safe and effective bacterium selected from the commensal skin microbiota of healthy animals, which can be applied to skin lesions to promote healing during dermatological diseases complicated by infection. Such an approach to therapy prevents further spread of resistance to antibiotics and thus the ineffectiveness of drugs due to resistance and helps to eliminate the use of non-ecological drugs.