Analysis of blood serum protein alterations in animals with parasitic diseases and comparison of species-related differences in the protein profile

Parasitic diseases are a serious health and economic problem in production animals and pose a serious risk also for companion animals. They are accompanied by the stimulation of immune responses and the initiation of systemic inflammatory reactions, including the increased production of some proteins. An important diagnostic potential of serum proteins as biomarkers also lies in the monitoring of treatment efficacy, assessing the restoration of impaired functions after therapy, as well as in determining prognosis. The project will therefore be focused on evaluating the course of inflammatory reactions in certain parasitic diseases in production and companion animals, analyzing changes in the production and distribution of serum proteins, the main inflammatory mediators and components of humoral immune response. In order to specify the diagnostically most appropriate proteins in the monitored animal species, species-related differences in the distribution of protein fractions will also be evaluated.