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ProjectsTransplantation of faecal microbiota and its potential application in non-specific inflammatory bowel diseases in human and veterinary medicine.

Transplantation of faecal microbiota and its potential application in non-specific inflammatory bowel diseases in human and veterinary medicine.

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IdentifierAPVV-23-0031
Funding schemeSlovak research and development agency
Principal investigator at UVLFGancarčíková Soňa, MVDr., PhD.
Project duration01.07.2024 – 30.06.2028
The symbiotic relationship between gut microbiota and the host is regulated and stabilised by a complex network of interactions that include mutual metabolic, immune and neuroendocrine relationships. Its adverse quantitative and qualitative changes referred to as dysbiosis result in the development of pathological conditions. This is the reason why dysbiosis can be considered as a biomarker of such disorders and the study of the balance of intestinal microbiota is one of the priorities of future therapy of diseases. The submitted project focuses on the study of the effect of faecal microbiota transplant (FMT) alone, and FMT enriched by natural additives and products of beneficial bacteria on pathogenesis of ulcerative colitis (UC) using innovative animal models. The aim of the project is to obtain the therapeutically most effective combination of FMT and natural additives or beneficial bacteria and its suitable application form usable in patients with non-specific inflammatory bowel diseases and capable of revitalising intestinal microbiota, increasing bacterial biodiversity and recovering optimum function of the intestinal ecosystem. The project is aimed at obtaining new knowledge in the area of research of the key role of intestinal microbiota in pathogenesis of ulcerative colitis that would contribute to the development of more effective methods or preparations for prevention of non-specific bowel inflammation with application in veterinary and human medicine.

Partners

  • University of Veterinary Medicine and Pharmacy in Košice (Project coordinator)
  • Pavol Jozef Šafárik University in Košice
  • National Agricultural and Food Centre

Project outputs

  1. PAČUTA, Ivan - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - HRČKOVÁ, Gabriela - ANDREJČÁKOVÁ, Zuzana - HAJDUČKOVÁ, Vanda - JANIČKO, Martin - BERTKOVÁ, Izabela - HIJOVÁ, Emília - STROJNÝ, Ladislav - KVAKOVÁ, Monika - AMBRO, Ľuboš - KAMLÁROVÁ, Anna - GUĽAŠOVÁ, Zuzana - MAĎAR, Marián - MUDROŇOVÁ, Dagmar - SOPKOVÁ, Drahomíra. Zápalové a apoptické markery ako dôležitý aspekt ulceróznej kolitídy u animálneho modelu s chemickou indukciou akútnej ulceróznej kolitídy. In: Mikro – Imuno Seminár Doktorandov 2024 : Zborník vedeckých prác. 1. vyd. Košice : UVLF, 2024. ISBN 978-80-8077-820-0, s. 55-60.

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  2. WÅLE, Julie Viken. Study of the influence of FMT from a patient with acute ulcerative colitis on pathogenesis of UC using a pseudo-germ-free animal model : diploma thesis [Štúdium vplyvu transplantácie fekálnej mikrobioty (FMT) od pacienta s akútnou ulceróznou kolitídou na patogenézu UC využitím pseudo germ-free animálneho modelu]. Košice : UVLF 2024. 60 l + CD-ROM.

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  3. BLAŽÍČKOVÁ, Laura. Vplyv transplantácie fekálnej mikrobioty na zmeny v dynamike metabolickej aktivity črevnej mikrobioty u animálneho modelu s indukciou ulceróznej kolitídy : diplomová práca. Košice : UVLF 2025. 60 l + CD-ROM.

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  4. LAUKO, Stanislav - GANCARČÍKOVÁ, Soňa - HAJDUČKOVÁ, Vanda - JANIČKO, Martin - HRČKOVÁ, Gabriela - HIJOVÁ, Emília - KVAKOVÁ, Monika - GULAŠOVÁ, Zuzana - STROJNÝ, Ladislav - AMBRO, Ľuboš - HERTELYOVÁ, Zdenka - MUDROŇOVÁ, Dagmar - DEMEČKOVÁ, Vlasta - ADAMKOVÁ, Petra - ANDREJČÁKOVÁ, Zuzana - RYNIKOVÁ, Mária - KAMLÁROVÁ, Anna - ŠTOFILOVÁ, Jana - SPIŠÁKOVÁ, Daniela - SOPKOVÁ, Drahomíra - BERTKOVÁ, Izabela. The impact of dysbiotic microbiota obtained from patient with ulcerative colitis on the pathogenesis of UC by utilizing animal model [Vplyv dysbiotickej mikrobioty získanej od pacienta s ulceróznou kolitídou na patogenézu UC využitím animálneho modelu]. In: Workshop for young Scientists "Hot Topics in Microbiology 2025". Hot Topics in Microbiology 2025 : Workshop for young Scientist. Book of Abstracts. Bratislava : Univerzita Komenského, 2025. ISBN 978-80-973411-7-6, s. 23.

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  5. SPIŠÁKOVÁ, Daniela - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - JANIČKO, Martin - HAJDUČKOVÁ, Vanda - DEMEČKOVÁ, Vlasta - RYNIKOVÁ, Mária - ADAMKOVÁ, Petra - MUDROŇOVÁ, Dagmar - BERTKOVÁ, Izabela. Evaluation of bacterial composition and viability of faecal microbiota transplant: comparative analysis of its frozen and lyophilized form [Evaluation of bacterial composition and viability of faecal microbiota transplant: comparative analysis of its frozen and lyophilized form]. In: Workshop for young Scientists "Hot Topics in Microbiology 2025". Hot Topics in Microbiology 2025 : Workshop for young Scientist. Book of Abstracts. Bratislava : Univerzita Komenského, 2025. ISBN 978-80-973411-7-6, s. 27.

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  6. LAUKO, Stanislav - GANCARČÍKOVÁ, Soňa - HAJDUČKOVÁ, Vanda - JANIČKO, Martin - HRČKOVÁ, Gabriela - HIJOVÁ, Emília - KVAKOVÁ, Monika - GUĽAŠOVÁ, Zuzana - STROJNÝ, Ladislav - AMBRO, Ľuboš - HERTELYOVÁ, Zdenka - MUDROŇOVÁ, Dagmar - DEMEČKOVÁ, Vlasta - ADAMKOVÁ, Petra - ANDREJČÁKOVÁ, Zuzana - RYNIKOVÁ, Mária - KAMLÁROVÁ, Anna - ŠTOFILOVÁ, Jana - SPIŠÁKOVÁ, Daniela - BERTKOVÁ, Izabela. Inovatívny animálny model indukcie akútnej ulceróznej kolitídy prostredníctvom FMT od pacienta s diagnostikovanou UC. In: Mikrobiológia okolo nás 2025. Mikrobiológia okolo nás 2025 : Zborník abstraktov. 1. vyd. Bratislava : Československá spoločnosť mikrobiologická, 2025. ISBN 978-80-973411-8-3, s. 14.

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  7. RYNIKOVÁ, Mária - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - MUDROŇOVÁ, Dagmar - JANIČKO, Martin - HAJDUČKOVÁ, Vanda - ADAMKOVÁ, Petra - DEMEČKOVÁ, Vlasta. Mikrobiómom vyvolaná disrupcia črevnej epitelovej bariéry ako potenciálny spúšťač chronického zápalu v ulceróznej kolitíde. In: Interaktívna Konferencia Mladých Vedcov 2025. Interaktívna Konferencia Mladých Vedcov 2025. Bratislava : Občianske združenie Preveda, 2025. ISBN 978-80-99936-86-8, s.

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  8. RYNIKOVÁ, Mária - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - MUDROŇOVÁ, Dagmar - HAJDUČKOVÁ, Vanda - ADAMKOVÁ, Petra - DEMEČKOVÁ, Vlasta. Harnessing the gut microbiome to optimize animal models of ulcerative colitis: Insights from a multi-omic approach. In: Targeting Microbiota : Padova : International Society of Microbiota, 2025. s. 118.

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  9. DEMEČKOVÁ, Vlasta - RYNIKOVÁ, Mária - ADAMKOVÁ, Petra - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - JANIČKO, Martin - HAJDUČKOVÁ, Vanda. Dual triggers, one therapy: Structural-functional analysis of fecal transplantation in ulcerative colitis. In: Targeting Microbiota : Padova : International Society of Microbiota, 2025. s. 72.

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  10. LAUKO, Stanislav - GANCARČÍKOVÁ, Soňa - HAJDUČKOVÁ, Vanda - JANIČKO, Martin - HRČKOVÁ, Gabriela - HIJOVÁ, Emília - KVAKOVÁ, Monika - GULAŠOVÁ, Zuzana - STROJNÝ, Ladislav - AMBRO, Ľuboš - HERTELYOVÁ, Zdenka - DEMEČKOVÁ, Vlasta - ADAMKOVÁ, Petra - ANDREJČÁKOVÁ, Zuzana - RYNIKOVÁ, Mária - KAMLÁROVÁ, Anna - ŠTOFILOVÁ, Jana - SPIŠÁKOVÁ, Daniela - BERTKOVÁ, Izabela. Obtaining a combined animal model of acute UC through exposure to DSS and microbiota from a patient with UC. In: Targeting Microbiota : Padova : International Society of Microbiota, 2025. s. 93.

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  11. RYNIKOVÁ, Mária - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - MUDROŇOVÁ, Dagmar - ADAMKOVÁ, Petra - JANIČKO, Martin - DEMEČKOVÁ, Vlasta. Exploring new animal models of ulcerative colitis: evaluating chemical and patient-derived microbial triggers to advance translational relevance. In: Laboratory animal research. 2026. ISSN 1738-6055, Vol. 42, no. 1 (2026), art. no. 21, p. [1-22].

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