Štúdium zmien v mikroflóre dentálnych biofilmov u ľudí a psov za účelom harmonizácie mikrobiocenózy ústnej dutiny pomocou vybraných orálnych probiotík

Probiotic bacteria have a positive effect on the harmonization of microbiocenosis of the oral cavity and are beginning to be used in both human and veterinary medicine. Recent studies with Lactobacillus reuteri (DSM 17938) and Streptococcus salivarius (K12) show benefits of these probiotics by inhibiting of pathogenic bacteria growth which cause otitis media, tonsillitis, halitosis, gingivitis, caries dentis, periodontitis, stomatitis aphtosa or candidosis in humans. Dogs have different dental biofilm bacteria because of their higher pH and lower amylase concentration, so they are used as probiotic Str. oralis (KJ3), Str. uberis (KJ2) and Str. rattus (JH145). Project focuses on the study of microflora and changes in dental biofilm microbiocenoses in humans and dogs, the search for suitable candidate microflora of dental biofilms by molecular methods, in vitro and in vivo tests.The findings will help in the development of preparations based on oral probiotic bacteria and their products in humans and dogs.