Study of immune mechanism for decreasing of presence Campylobacter jejuni in intestine of poultry after application of probiotics

Campylobacteriosis is the most frequent cause of bacterial enteritidis in man and poultry is the main reservoir of infected pathogen. Increasing of natural immunity in intestinal tract with probiotic bacteria is one of the possible alternatives for elimination of campylobacteriosis. Selection of the most suitable probiotic strains tested under in vitro conditions will allow primary selection of effective probiotics for in vivo using application. The results obtained from the study of toll-like receptors, changes in the secretion of mucin, IgA, adhesins receptors of pathogen and their interaction with intestinal mucosa will help to understand the mechanisms of the effect of probiotics and they enable an effective approach for livestock to reduce Campylobacter jejuni contamination.