Štúdium morfometrických zmien kolenného kĺbu vo vzťahu k ruptúre predného skríženého väzu a využitie niektorých prvkov regeneratívnej medicíny v terapii modifikujúcej ochorenie kolenného kĺbu u psov

We measured morphometrics parameters on hind leg in yorkshire terrier dogs based on x ray in groups of dogs with cranial cruciate ligament rupture, witth cranial cruciate rupture and patellar luxation and in dogs with patellar luxation. Based on our results we can conclude that yorkshire terriers with different clinical findings have differing bone morphology. Double intraarticular aplication of 1ml of conditioned medium canine adipose – derived mesenchymal stem cells in interval of 14 dayes resulted in significant changes in concentration of biomoleculs associated with osteoarthrosis (MMP-3, TIMP-1, IL-6 a TNF-?). Also other cytokines playing an role in osteoarthrosis pathogenesis (IFN-?, IL-12, IL-2, IL-8, IL-10) have been slightly affected. At the same time statistically significant improvement in range of motion was demonstrated on osteoarthritic joint in dog in 42 dayes since first application.