Bacterial infection of intestine in chickens and regulation of cytokine levels by application of probiotic bacterie
| Identifier | 1/0313/12 |
|---|---|
| Funding scheme | Scientific grant agency (Ministry of education, science, research and sport of the Slovak Republic) |
| Principal investigator at UVLF | Levkut Mikuláš, prof. MVDr., DrSc. |
| Name of the project’s principal investigator | vysokoškolský pedagóg- profesor |
| Project duration | 01.01.2012 – 31.12.2014 |
Several infectious diseases including salmonellosis and campylobacteriosis cause enteritidis in poultry and concurrently are the most common bacterial causes of infectious diarrhea in children. Understanding mechanism of arising initial lesions on the epithelial covering of intestine tract and changes in the level of cytokines after infection with Salmonella enterica or Campylobacter species in this project will be able to determine the effective period of aplication and optimalize dose of bacteria with antagonistic activity - probiotic microorganisms. Selection of most suitable probiotic strains under in vitro conditions and during modulation of lesions in the mucus of intestine tract and affection of production of cytokines in infected animals will result in to define probiotics with the most effective preventive effect against above mentioned pathogens.