Modulation of immune system of mucous intestine of chickens infected with Campylobacter spp.

Campylobacteriosis is the most frequent zoonotic disease in humans worldwide. Poultry meat contaminated by Campylobacter jejuni (C. jejunu) is an important source of this enteric zoonosis. Broiler chickens are the common natural host for this pathogen. Therefore, intervention at the farm level by reducingpathogen colonisation should be taken into consideration in any control policy.Understanding of mechnismof arising initial lesions in the epithelial covering of intestinal tract and changes at the levelof cytokinesafter infection with Campylobacter spp. in this project will be able to determine the effective period of administration and optimalize the dose of probiotic bacteria with antagonistic activity against C. jejuni. Modulation of expression if mRNA IgA and production of secreted IgA into intestinal tract and interaction with cytokines and mucin will result in to define probiotic bacteria with preventive effect against C. jejuni.