Genomická a klinická analýza očných ochorení v populácii národného plemena Československý vlčiak na Slovensku

Hereditary eye diseases in dogs primarily affect vision and quality of life. The clinical diagnosis of hereditary diseases at an early stage of life is often unclear or ambiguous. With the development of veterinary medicine and molecular biology, it is now possible to identify not only individuals with clinical symptoms but also carriers of risk alleles and selectively select individuals for the breeding cycle of the breed. However, extensive studies focusing on the occurrence of eye diseases in various breeds have not yet provided sufficient data on the genetic burden of inherited eye diseases in our national breed Czechoslovak Wolfdog. The genetic background of this breed, part of which came from the German Shepherd, provided certain risk alleles of genes causing diseases such as dwarfism, degenerative myelopathy, or hip dysplasia. The objectives of the project is to detect the presence of risk alleles for commonly manifesting inherited diseases using genomic analyses and to identify new forms of the gene