Blood serum proteins and their use as biomarkers in the diagnosis of diseases in farm animals
| Identifier | 1/0447/14 |
|---|---|
| Funding scheme | Scientific grant agency (Ministry of education, science, research and sport of the Slovak Republic) |
| Principal investigator at UVLF | Tóthová Csilla, MVDr., PhD. |
| Project duration | 01.01.2014 – 31.12.2016 |
Many health disorders and diseases are associated with changes in blood serum protein concentrations and occurence of dysproteinemias. Every changes in the organism and impairment of the homeostasis may cause changes in the concentrations and proportion of blood serum proteins. The determination of total serum protein concentrations is the basic laboratory method for the evaluation of serum proteins also in farm animals. However, this method is not informative enough to describe and specify the decreased or increased production of proteins, because changes in the concentrations of one protein need not to express in total serum protein concentrations. In case of pathological total serum protein concentrations and suspected dysproteinemias it is necessary to perform further analyses, including serum protein electrophoresis and the determination of selected specific proteins of the blood serum. Despite their advantages, these analyses are in the veterinary medicine rarely used laboratory methods for the evaluation of dysproteinemias. Many serum proteins may be diagnostically important. From this reason, many of them may be used as useful biomarkers by the evaluation of various important diseases also in farm animals.