ProjectsMorphological and functional changes in the gastrointestinal tract of pseudo germ-free animal model with transplant of faecal microbiota from children with autism spectrum disorders.

Morphological and functional changes in the gastrointestinal tract of pseudo germ-free animal model with transplant of faecal microbiota from children with autism spectrum disorders.

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Identifier	1/0139/25
Funding scheme	Scientific grant agency (Ministry of education, science, research and sport of the Slovak Republic)
Principal investigator at UVLF	Gancarčíková Soňa, MVDr., PhD.
Project duration	01.01.2025 – 31.12.2028

The evidence implying that the microbiota-intestine-brain axis communicates bidirectionally raises the question whether untreated gastrointestinal (GIT) problems in children with autism spectrum disorders (ASD) can directly affect their neurodevelopment or, contrariwise, whether the neurodevelopment disorders predispose the child to chronic GIT problems. The aim of the project is to observe the influence of a transplant of faecal microbiota from children with ASD on clinical- histopathological response and on changes in the microenvironment of bowel in pathogenesis of ASD associated GIT disorders, and to develop more effective way of manipulation of the dysbiotic microbiota in ASD children, namely by their modification by means of transplantation of faecal microbiota from neurotypical children, beneficial microorganisms and effective natural compounds.

Partners

University of Veterinary Medicine and Pharmacy in Košice (Project coordinator)
Pavol Jozef Šafárik University in Košice
Pavol Jozef Šafárik University in Košice

Project outputs

NÉMETOVÁ, Daniela - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - HRČKOVÁ, Gabriela - HAJDUČKOVÁ, Vanda - DEMEČKOVÁ, Vlasta - RYNIKOVÁ, Mária - RODÁKOVÁ, Kristína - ŠTEFANCOVÁ, Diana - LECOVÁ, Martina - SASHOVA TOMOVA, Aleksandra - RAŠKOVÁ, Barbara - OSTATNÍKOVÁ, Daniela - PAČUTA, Ivan - STROMPFOVÁ, Viola - KUBAŠOVÁ, Ivana - SOPKOVÁ, Drahomíra. Morfologické a funkčné zmeny gastrointestinálneho traktu asociované s poruchami autistického spektra u pseudo germ-free (PGF) animálneho modelu. In: Mikro – Imuno Seminár Doktorandov 2024 : Zborník vedeckých prác. 1. vyd. Košice : UVLF, 2024. ISBN 978-80-8077-820-0, s. 27-31.
Publication details
BABJÁKOVÁ, Diana - LECOVÁ, Martina - RODÁKOVÁ, Kristína - GANCARČÍKOVÁ, Soňa - SOPKOVÁ, Drahomíra - VLČKOVÁ, Radoslava. Vplyv metabolitov ľanového semena na proliferáciu a apoptózu buniek endometria myší [The effect of flaxseed metabolites on proliferation and apoptosis in the mouse endometrium]. In: 27. Košický morfologický deň: Miesto morfológie v súčasnej medicíne : Zborník vedeckých prác. 1. vyd. Košice : UPJŠ v Košiciach, 2024. ISBN 978-80-574-0313-5, online, s. 17-22.
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BABJÁKOVÁ, Diana - LECOVÁ, Martina - RODÁKOVÁ, Kristína - GANCARČÍKOVÁ, Soňa - SOPKOVÁ, Drahomíra - VLČKOVÁ, Radoslava. The effect of enterolactone and n-3 PUFAs on the proliferation and apoptosis in the mouse endometrium. In: Animal Physiology 2024. Animal Physiology 2024 : Book of abstracts from 19th International Scientific Conference. 1. vyd. Nitra : SPU v Nitre, 2024. ISBN 978-80-552-2744-3, online, s. 12.
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ŠUHAJDOVÁ, Gabriela. Vplyv fekálnej transplantácie mikrobiómu na aktivitu tráviacich enzýmov u myší : diplomová práca. Košice : UVLF 2025. 58 l + CD-ROM.
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RODÁKOVÁ, Kristína - ANDREJČÁKOVÁ, Zuzana - VLČKOVÁ, Radoslava - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - SPIŠÁKOVÁ, Daniela - KOZIOŁ, Katarzyna - DEMEČKOVÁ, Vlasta - KOZIOROWSKA, Anna - RYNIKOVÁ, Mária - STROMPFOVÁ, Viola - SASHOVA TOMOVA, Aleksandra - OSTATNÍKOVÁ, Daniela - SOPKOVÁ, Drahomíra. Pancreatic lipase secretion in the pancreas and its production in duodenal enterocytes following fecal microbiota transplantation, probiotics, and prebiotic administration in a pseudo germ-free animal model. In: Morphology 2025 : Olomouc : UNIVERZITA PALACKÉHO, 2025. ISBN 978-80-244-6680-4, s. 64-65.
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GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - SPIŠÁKOVÁ, Daniela - DEMEČKOVÁ, Vlasta - RYNIKOVÁ, Mária - ŠMAJDA RODÁKOVÁ, Kristína - STROMPFOVÁ, Viola - HRČKOVÁ, Gabriela - FARKAŠOVÁ, Soňa - RAŠKOVÁ, Barbara - OSTATNÍKOVÁ, Daniela - SASHOVA TOMOVA, Aleksandra. Effects of probiotic and prebiotic modulation of gut microbiota on gastrointestinal symptoms associated with autism spectrum disorders. In: Targeting Microbiota : Padova : International Society of Microbiota, 2025. s. 75.
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SUŠIENKOVÁ, Petronela - KORITKOVÁ, Dominika Monika - DUDOVÁ, Natália - BORBÉLYOVÁ, Diana - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - RODÁKOVÁ, Kristína - SPIŠÁKOVÁ, Daniela - SASHOVA TOMOVA, Aleksandra. Vplyv transplantácie fekálneho mikrobiómu na správanie podobné poruchám autistického spektra u samíc pseudo germ-free myší. In: 100. Fyziologické dny : Praha : Fyziologický ústav 1. lékařské fakulty Univerzity Karlovy, 2025. s. 51-52.
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ŠMAJDA RODÁKOVÁ, Kristína - GANCARČÍKOVÁ, Soňa - DEMEČKOVÁ, Vlasta - LAUKO, Stanislav - RYNÍKOVÁ, Mária - ANDREJČÁKOVÁ, Zuzana - SPIŠÁKOVÁ, Daniela - FUSEK, Michal - VLČKOVÁ, Radoslava - STROMPFOVÁ, Viola - TOMOVÁ, Alexandra - RAŠKOVÁ, Barbara - SOPKOVÁ, Drahomíra. Modulation of gut–liver axis by ASD-associated microbiota and synbiotic intervention in a pseudo-germ-free mouse model. In: Applied Sciences. 2026. ISSN 2076-3417, Vol. 16, no. 11 (2026), art. no. 5529, p. [1-35]. (2024: 2.5 - IF, 162 - H-index, 2.7 - IF 5y, 0.521 - SJR, Q2 - SJR Best Q, Q2 - JCR Best Q, 0.438 - ABDC).
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RYNIKOVÁ, Mária - GANCARČÍKOVÁ, Soňa - LAUKO, Stanislav - MUDROŇOVÁ, Dagmar - ADAMKOVÁ, Petra - JANIČKO, Martin - DEMEČKOVÁ, Vlasta. Exploring new animal models of ulcerative colitis: evaluating chemical and patient-derived microbial triggers to advance translational relevance. In: Laboratory animal research. 2026. ISSN 1738-6055, Vol. 42, no. 1 (2026), art. no. 21, p. [1-22].
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