Immune response of intestinal mucous in chickens with modulated organic Zinc and challenged with Eimeria spp.
| Identifier | 1/0575/16 |
|---|---|
| Funding scheme | Scientific grant agency (Ministry of education, science, research and sport of the Slovak Republic) |
| Principal investigator at UVLF | Levkut Martin, doc. MVDr., PhD. |
| Project duration | 01.01.2016 – 31.12.2018 |
Zinc (Zn) is a nutritionally essential trace element that functions numerous metabolic pathways. It plays important role in immune functions. The latest research demonstrate, that zins in inorganic form has low utilization for poultry bring serious environment pollution. Organic zinc complex mainly zinc-glycin (Zn-G) is more effective on immune system of intestinal mucus in poultry. Its beneficial effect in complex zinc-glycin is found mainly in the expression of IgA and mucin genes in the intestine of healthy chickens. It is supposed that influence of organic complex Zn-glycin improve activity of macrophages at the destruction of Eimeria sp. sporozoites. From the immunocompetent cells mainly macrophages are responsible for the phagocytation and destruction of intra and extracellular pathogens. Species, E.acervulina, E. maxima and E. tenella, are the most commonly isolated from the GIT of poultry. Evaluation of chemokine, cytokine expression offers insight into response to Zn- Gly on invasion of Eimeria.