Bioinformatic and molecular tools to study factors of pathogenicity and virulence of the medically important bacterial pathogens

The project is aimed at generation of the database of the factors of pathogenicity and virulence of important bacterial pathogens of medical importance, mainly of zoonotic origin (the infections transmitted between animals and man). Historically, the factors of the pathogenicity and virulence of the bacterial pathogens are being studied using live organisms in in vivo or in vitro conditions. However, with the current advances in the whole genome sequencing technology, genomes of the several (if not all) pathogens are unfolded, which has open the opportunities of in silico analysis of the factors of virulence (e.g. homology study, computer simulations, etc.). Study of the factors of virulence is not only important to understand molecular basis of the pathogenesis, but also, necessary for the fields of diagnostics, therapy and drug development. Members of the proposed project have recently published a book dedicated to the Gram-negative and Gram-positive bacteria of medical importance. These books are being popular among the students, PhD fellows and researchers in biomedical sciences. With this positive feedback, members of this proposed project feel that there is need of next monograph devoted for factors of the virulence of these bacteria. The proposed book will increase our knowledge in the field of host-pathogen interactions, pathogenesis and immune evasion strategies employed by bacteria. The project is also planning to make e-learning and will organize workshop focused on the factors of virulence of bacteria. Main aim here is to disseminate advanced knowledge in the field of among broad spectrum of students, researchers and doctoral fellows. To train them to use advance databses and on-line application for study of factors of virulence. This goal will be achieved through: 1. Publishing the manuscript entitled: Bioinformatics and molecular tools to study factors of pathogenicity and virulence of the medically important bacterial pathogens, 2. Organization of workshops dedicated to bioinformatics tools, 3. Providing on-line technical support for working with databases.