Localized intrathecal delivery of mesenchymal stromal cells conditioned medium improves functional recovery in a rat model of spinal cord injury

MODARRESI, Farrokh - KAKA, Gholam Reza - RAEI, Mehdi - REZAEI-TAZANGI, Fatemeh. Therapeutic effectiveness of conditioned medium derived from adipose tissue mesenchymal stem cells and dehydroepiandrosterone in a rat model of spinal cord injury. In IBRO NEUROSCIENCE REPORTS, 2026, vol. 20, no., pp. 264-275. ISSN 2667-2421. Dostupné na: https://doi.org/10.1016/j.ibneur.2025.12.010.

CAROZZA, Giulia - ZERTI, Darin - PULCINI, Fanny - LANCIA, Loreto - DELLE MONACHE, Simona - MATTEI, Vincenzo - MACCARONE, Rita. Conditioned media from dental pulp stem cells to counteract age-related macular degeneration. In Experimental Eye Research, 2025-01-01, 250, pp. ISSN 00144835. Dostupné na: https://doi.org/10.1016/j.exer.2024.110167.

HAJISOLTANI, Razieh - TAGHIZADEH, Mona - HAMBLIN, Michael R. - RAMEZANI, Fatemeh. Conditioned Medium Treatment for the Improvement of Functional Recovery after Spinal Cord Injury: A Meta-Analysis Study. In Current Stem Cell Research and Therapy, 2025-01-01, 20, 4, pp. 389-408. ISSN 1574888X. Dostupné na: https://doi.org/10.2174/011574888X283713240129095031.

KAKA, Gholam Reza - MODARRESI, Farrokh. Conditioned medium derived from mesenchymal stem cells and spinal cord injury: A review of the current therapeutic capacities. In Ibro Neuroscience Reports, 2025-06-01, 18, pp. 293-299. ISSN 26672421. Dostupné na: https://doi.org/10.1016/j.ibneur.2025.02.004.

SHEN, Yang Jin - HUANG, Yin Cheng - CHENG, Yi Chuan. Advancements in Antioxidant-Based Therapeutics for Spinal Cord Injury: A Critical Review of Strategies and Combination Approaches. In Antioxidants, 2025-01-01, 14, 1, pp. Dostupné na: https://doi.org/10.3390/antiox14010017.

ASSUNCAO-SILVA, R.C. - PINHO, A. - CIBRAO, J.R. - PEREIRA, I.M. - MONTEIRO, S. - SILVA, N.A. - CAMPOS, J. - REBELO, A.L. - SCHLOSSER, G. - PINTO, L. - PANDIT, A. - SALGADO, A.J. Adipose tissue derived stem cell secretome induces motor and histological gains after complete spinal cord injury in Xenopus laevis and mice. In JOURNAL OF TISSUE ENGINEERING. ISSN 2041-7314, 2024, vol. 15, no. , p. 15-21.

DARWISH, Mariam - EL HAJJ, Rojine - KHAYAT, Luna - ALAAEDDINE, Nada. Stem Cell Secretions as a Potential Therapeutic Agent for Autism Spectrum Disorder: A Narrative Review. In Stem Cell Reviews and Reports, 2024-07-01, 20, 5, pp. 1252-1272. ISSN 26293269. Dostupné na: https://doi.org/10.1007/s12015-024-10724-4.

HELLENBRAND, Daniel J. - QUINN, Charles M. - PIPER, Zachariah J. - ELDER, Ryan T. - MISHRA, Raveena R. - MARTI, Taylor L. - OMURO, Phoebe M. - RODDICK, Rylie M. - LEE, Jae Sung - MURPHY, William L. - HANNA, Amgad S. The secondary injury cascade after spinal cord injury: an analysis of local cytokine/chemokine regulation. In Neural Regeneration Research, 2024-06-01, 19, 6, pp. 1308-1317. ISSN 16735374. Dostupné na: https://doi.org/10.4103/1673-5374.385849.

POURHADI, Masoumeh - ZALI, Hakimeh - GHASEMI, Rasoul - FAIZI, Mehrdad - MOJAB, Faraz - SOUFI ZOMORROD, Mina. Restoring Synaptic Function: How Intranasal Delivery of 3D-Cultured hUSSC Exosomes Improve Learning and Memory Deficits in Alzheimer’s Disease. In Molecular Neurobiology, 2024-06-01, 61, 6, pp. 3724-3741. ISSN 08937648. Dostupné na: https://doi.org/10.1007/s12035-023-03733-w.

DA SILVA, Andreia Valente - SERRENHO, Inês - ARAÚJO, Beatriz - CARVALHO, Alexandre Martins - BALTAZAR, Graça. Secretome as a Tool to Treat Neurological Conditions: Are We Ready? In International Journal of Molecular Sciences, 2023-11-01, 24, 22, pp. ISSN 16616596. Dostupné na: https://doi.org/10.3390/ijms242216544.

GIOVANNELLI, L. - BARI, E. - JOMMI, C. - TARTARA, F. - ARMOCIDA, D. - GARBOSSA, D. - COFANO, F. - TORRE, M.L. - SEGALE, L. Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: Risk-benefit profile and next steps for the market access. In Bioactive materials. ISSN 2452-199X, 2023, vol. 29, p. 16-35.

MELIKOV, Ziia K. - MEDVEDIEV, Volodymyr V. Peripheral nerve injury: molecular pathophysiology and prospects for restorative treatment by means of cell transplantation: a literature review. In Ukrainian Neurosurgical Journal, 2023-12-26, 29, 4, pp. 3-12. ISSN 26639084. Dostupné na: https://doi.org/10.25305/unj.288785.

MERLO, Barbara - IACONO, Eleonora. Beyond Canine Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Transplantation: An Update on Their Secretome Characterization and Applications. In Animals, 2023-11-01, 13, 22, pp. Dostupné na: https://doi.org/10.3390/ani13223571.

SEMITA, I. Nyoman - UTOMO, Dwikora Novembri - SUROTO, Heri - SUDIANA, I. Ketut. The Role of Human Neural Stem Cell Secretomes on the Repair of Spinal Cord Injury Post-laminectomy in Rattus norvegicus Through the Analysis of Basso–Beattie–Bresnahan Score Locomotors, Interleukin-10, Matrix Metalloproteinase 9, and Transforming Growth Factor-β. In Asian Spine Journal, 2023-01-01, 17, 2, pp. 231-239. ISSN 19761902. Dostupné na: https://doi.org/10.31616/ASJ.2022.0152.

SEMITA, I.N. - UTOMO, D.N. - SUROTO, H. Mechanism of spinal cord injury regeneration and the effect of human neural stem cells-secretome treatment in rat model. In WORLD JOURNAL OF ORTHOPEDICS. ISSN 2218-5836, 2023, vol. 14, no. 2, p. 64-82.

ARAÚJO, Bruna - SILVA, Rita Caridade - DOMINGUES, Sofia - SALGADO, António J. - TEIXEIRA, Fábio G. Mesenchymal Stem Cell Secretome: A Potential Biopharmaceutical Component to Regenerative Medicine. In Handbook of Stem Cell Therapy: Volume 1, 2022-01-01, pp. 973-1005. Dostupné na: https://doi.org/10.1007/978-981-19-2655-6_46.

ASSUNCAO SILVA, Rita C. - PINTO, Luisa - SALGADO, Antonio J. Cell transplantation and secretome based approaches in spinal cord injury regenerative medicine. In MEDICINAL RESEARCH REVIEWS, 2022, vol. 42, no. 2, pp. 850-896. ISSN 0198-6325. Dostupné na: https://doi.org/10.1002/med.21865.

SARVEAZAD, Arash - TOLOUI, Amirmohammad - MOARREFZADEH, Aida - NAFCHI, Hanieh Ghasemian - NEISHABOORI, Arian Madani - YOUSEFIFARD, Mahmoud. Mesenchymal Stem Cell-Conditioned Medium Promotes Functional Recovery Following Spinal Cord Injury: A Systematic Review and Meta-analysis. In SPINE SURGERY AND RELATED RESEARCH, 2022, vol. 6, no. 5, pp. 433-442. ISSN 2432-261X. Dostupné na: https://doi.org/10.22603/ssrr.2022-0004.

BAR, Julia K. - LIS-NAWARA, Anna - GRELEWSKI, Piotr Grzegorz. Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential. In INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, vol. 22, no. 21, pp.

DENG, Wu-Sheng - YANG, Kun - LIANG, Bing - LIU, Ying-Fu - CHEN, Xu-Yi - ZHANG, Sai. Collagen/heparin sulfate scaffold combined with mesenchymal stem cells treatment for canines with spinal cord injury: A pilot feasibility study. In JOURNAL OF ORTHOPAEDIC SURGERY. ISSN 1022-5536, 2021, vol. 29, no. 2, pp.