Stem cell conditioned medium treatment for canine spinal cord injury: pilot feasibility study

SUWANKANIT, K. - THAYANANUPHAT, A. - CHATCHAISAK, D. Dual-route administration of adipose tissue-derived mesenchymal stem cells (Ad-MSCs) for the treatment of spinal cord injury in a dog: a case report. In Veterinary Integrative Sciences. ISSN 2629-9968, 2026, vol.24, no. 3, art. no. e2026086.

WINDSOR, Rebecca. Stem cell therapy for rare neurological diseases: translational research opportunities. In Rare Disease and Orphan Drugs Journal, 2026-04-01, 5, 2, pp. Dostupné na: https://doi.org/10.20517/rdodj.2025.85.

AL-MIJALLI, Samiah Hamad - MRABTI, Hanae Naceiri - ELBOUZIDI, Amine - ASHMAWY, Naglaa S. - BATBAT, Amine - ABDALLAH, Emad M. - LAABOUDI, Wafa - ALADHADH, Mohammed - ALSHABRMI, Fahad M. - ALNASSER, Sulaiman Mohammed - ADDI, Mohamed - EL HACHLAFI, Naoufal. Thymus serpyllum L. Essential Oil: Phytochemistry and in Vitro and in Silico Screening of Its Antimicrobial, Antioxidant and Anti-Inflammatory Properties. In Phyton International Journal of Experimental Botany, 2025-01-01, 94, 1, pp. 209-227. ISSN 00319457. Dostupné na: https://doi.org/10.32604/phyton.2025.060438.

GUGJOO, Mudasir Bashir. Stem Cell-Based Regenerative Medicine in Canine Practice. In Stem Cell Based Regenerative Medicine in Canine Practice, 2025-01-01, pp. 1-553. ISBN [9781394253258, 9781394253289]. Dostupné na: https://doi.org/10.1002/9781394253289.

KAKA, Gholam Reza - MODARRESI, Farrokh. Conditioned medium derived from mesenchymal stem cells and spinal cord injury: A review of the current therapeutic capacities. In Ibro Neuroscience Reports, 2025-06-01, 18, pp. 293-299. ISSN 26672421. Dostupné na: https://doi.org/10.1016/j.ibneur.2025.02.004.

JEUNG, Soyoung - AN, Ju Hyun - KIM, Sung Soo - YOUN, Hwa Young. Safety and efficacy of canine gonadal tissue-derived mesenchymal stem cells for early myxomatous mitral valve disease. In Frontiers in Veterinary Science, 2024-01-01, 11, pp. Dostupné na: https://doi.org/10.3389/fvets.2024.1404607.

MA, Ziqian - LIU, Tao - LIU, Liang - PEI, Yilun - WANG, Tianyi - WANG, Zhijie - GUAN, Yun - ZHANG, Xinwei - ZHANG, Yan - CHEN, Xueming. Epidermal Neural Crest Stem Cell Conditioned Medium Enhances Spinal Cord Injury Recovery via PI3K/AKT-Mediated Neuronal Apoptosis Suppression. In Neurochemical Research, 2024-10-01, 49, 10, pp. 2854-2870. ISSN 03643190. Dostupné na: https://doi.org/10.1007/s11064-024-04207-8.

MILI, Bhabesh - CHOUDHARY, Om Prakash. Advancements and mechanisms of stem cell-based therapies for spinal cord injury in animals. In International journal of surgery (London, England), 2024-10-01, 110, 10, pp. 6182-6197. Dostupné na: https://doi.org/10.1097/JS9.0000000000001074.

PICAZO, Rosa Ana - ROJO, Concepción - RODRIGUEZ-QUIROS, Jesus - GONZÁLEZ-GIL, Alfredo. Current Advances in Mesenchymal Stem Cell Therapies Applied to Wounds and Skin, Eye, and Neuromuscular Diseases in Companion Animals. In Animals, 2024-05-01, 14, 9, pp. Dostupné na: https://doi.org/10.3390/ani14091363.

CALIANI CARRERA, Alefe Luiz - MINTO, Bruno Watanabe - MALARD, Patrícia - BRUNEL, Hilana Dos Santos Sena. The Role of Mesenchymal Stem Cell Secretome (Extracellular Microvesicles and Exosomes) in Animals' Musculoskeletal and Neurologic-Related Disorders. In Veterinary Medicine International, 2023-01-01, 2023, pp. Dostupné na: https://doi.org/10.1155/2023/8819506.

FARID, Mariam F. - ABOUELELA, Yara S. - YASIN, Noha A.E. - AL-MOKADDEM, Asmaa K. - PRINCE, Abdelbary - IBRAHIM, Marwa A. - RIZK, Hamdy. Laser-activated autologous adipose tissue-derived stromal vascular fraction restores spinal cord architecture and function in multiple sclerosis cat model. In Stem Cell Research and Therapy, 2023-12-01, 14, 1, pp. Dostupné na: https://doi.org/10.1186/s13287-022-03222-2.

METWALLY, Elsayed - AL-ABBADI, Hatim A. - HUSSAIN, Tarique - MURTAZA, Ghulam - ABDELLATIF, Ahmed M. - AHMED, Mahmoud F. Calpain signaling: from biology to therapeutic opportunities in neurodegenerative disorders. In Frontiers in Veterinary Science, 2023-01-01, 10, pp. Dostupné na: https://doi.org/10.3389/fvets.2023.1235163.

SALARI SEDIGH, Hamideh - SAFFARPOUR, Anna - JAMSHIDI, Shahram - ASHOURI, Mahdi - NASSIRI, Seyed Mahdi - DEHGHAN, Mohammad Mehdi - RANJBAR, Esmail - SHAFIEIAN, Reyhaneh. In vitro investigation of canine periodontal ligament-derived mesenchymal stem cells: A possibility of promising tool for periodontal regeneration. In Journal of Oral Biology and Craniofacial Research, 2023-05-01, 13, 3, pp. 403-411. ISSN 22124268. Dostupné na: https://doi.org/10.1016/j.jobcr.2023.03.010.

CHANDRA, Vikash - SHARMA, G. Taru. Prospects of Mesenchymal Stem Cell Secretome in Veterinary Regenerative Therapy. In Stem Cells in Veterinary Science, 2022-01-01, pp. 271-287. Dostupné na: https://doi.org/10.1007/978-981-16-3464-2_16.

CHEN, Chung-Chao - YANG, Shu-Fang - WANG, Ing-Kae - HSIEH, Sing-Ying - YU, Jian-Xi - WU, Tze-Lien - HUANG, Wan-Jhen - SU, Min-Hao - YANG, Heng-Leng - CHANG, Pi-Chen - TENG, Ann-Chi - CHEN, Chia-Yi - LIANG, Sao-Ling. The Long-Term Efficacy Study of Multiple Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cells Transplantations Combined With Surgery in Four Dogs With Lumbosacral Spinal Cord Injury. In CELL TRANSPLANTATION, 2022, vol. 31, no., pp. ISSN 0963-6897. Dostupné na: https://doi.org/10.1177/09636897221081487.

FARID, Mariam F. - ABOUELELA, Yara S. - RIZK, Hamdy. Stem cell treatment trials of spinal cord injuries in animals. In AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2022, vol. 238, no., pp. ISSN 1566-0702. Dostupné na: https://doi.org/10.1016/j.autneu.2021.102932.

GUGJOO, Mudasir Bashir - AMARPAL - SAXENA, A. C. - KUMAR, Rohit - KINJAVDEKAR, P. - PAWDE, A. M. - SHARMA, G. Taru. Therapeutic Applications of Mesenchymal Stem Cells in Canine Diseases. In Stem Cells in Veterinary Science, 2022-01-01, pp. 241-253. Dostupné na: https://doi.org/10.1007/978-981-16-3464-2_14.

GUGJOO, Mudasir Bashir - FAROOQ, Fajar - SAKEENA, Qumaila - DAR, Ejaz Rasool - KHAN, Sharun - AMARPAL - PARRAH, Jalal-Ud Din - MAKHDOOMP, Dil Mohammad - DHAMA, Kuldeep - SHARMA, Gutulla Taru. Stem Cell Therapeutics in veterinary medicine in India. In INDIAN JOURNAL OF ANIMAL SCIENCES, 2022, vol. 92, no. 5, pp. 533-544. ISSN 0367-8318.

GUGJOO, Mudasir Bashir. Therapeutic Applications of Mesenchymal Stem Cells in Veterinary Medicine. In Therapeutic Applications of Mesenchymal Stem Cells in Veterinary Medicine, 2022-01-01, pp. 1-408. Dostupné na: https://doi.org/10.1007/978-981-19-3277-9.

HAQUE, Nazmul - WIDERA, Darius - GOVINDASAMY, Vijayendran - SOESILAWATI, Pratiwi - ABU KASIM, Noor Hayaty. Extracellular Vesicles from Stem and Progenitor Cells for Cell-Free Regenerative Therapy. In CURRENT MOLECULAR MEDICINE, 2022, vol. 22, no. 2, pp. 120-131. ISSN 1566-5240. Dostupné na: https://doi.org/10.2174/1566524021666210125114828.