Evaluation of DNA damage and cytotoxicity induced by triazole fungicide in cultured bovine lymphocytes

VILAS BÔAS CORREIA, Lucas - CARVALHAL DE AGUIAR, Gabriel - DOS SANTOS PEREIRA, Aparecida Marta Regina - DE SANTANA CARDOSO THOMAZ, Lucas - CORREIA DOS SANTOS DE OLIVEIRA, Isabelly Cristina - DE BRITTO MARI, Renata - PEROBELLI, Juliana Elaine - ARAKI RIBEIRO, Daniel - BARBOSA DA SILVA, Regina Cláudia. Triazole fungicides induce genotoxicity via oxidative stress in mammals in vivo: a comprehensive review. In Reviews on Environmental Health. ISSN 0048-7554, 41, 1 (2026-03-01), pp. 142-151. Dostupné na: https://doi.org/10.1515/reveh-2025-0051.

GORLA, Nora Bibiana M. - NIEVES, Mariela - FERRE, Daniela Marisol. Genotoxicity in Unconventional Mammalian Models of Wild, Urban, and Agricultural Ecosystems: A Systematic Review Under the One Health Approach. In GENES, 2025, vol. 16, no. 5, pp. Dostupné na: https://doi.org/10.3390/genes16050525.

RASGELE, Pinar Goc. Comparative Assessment of Short- and Long-Term Effects of Triadimenol Fungicide on Danio rerio Erythrocytes Using the Micronucleus and Erythrocyte Nuclear Abnormality Assays. In TOXICS, 2025, vol. 13, no. 3, pp. Dostupné na: https://doi.org/10.3390/toxics13030199.

CAMPANI, Tommaso - CASINI, Silvia - MACCANTELLI, Andrea - TOSONI, Filippo - D’AGOSTINO, Antonella - CALIANI, Ilaria. Oxidative stress and DNA alteration on the earthworm Eisenia fetida exposed to four commercial pesticides. In Environmental Science and Pollution Research, 2024-05-01, 31, 24, pp. 35969-35978. ISSN 09441344. Dostupné na: https://doi.org/10.1007/s11356-024-33511-7.

LOUATI, Kaouthar - KOLSI, Fatma - KALLEL, Rim - GDOURA, Yassine - BORNI, Mahdi - HAKIM, Leila Sellami - ZRIBI, Rania - CHOURA, Sirine - MAALEJ, Amina - SAYADI, Sami - CHAMKHA, Mohamed - MNIF, Basma - KHEMAKHEM, Zouheir - BOUDAWARA, Tahya Sellami - BOUDAWARA, Mohamed Zaher - SAFTA, Fathi. Research of Pesticide Metabolites in Human Brain Tumor Tissues by Chemometrics-Based Gas Chromatography-Mass Spectrometry Analysis for a Hypothetical Correlation between Pesticide Exposure and Risk Factor of Central Nervous System Tumors. In ACS Omega, 2023-08-15, 8, 32, pp. 29812-29835. Dostupné na: https://doi.org/10.1021/acsomega.3c04592.

FENG, Jianguo - SUN, Li - CHEN, Wang - WEI, Nuo - HOU, Chaoqun - CHEN, Zhiyang - MENG, Fei - CAO, Hongen. Synthesis, antifungal evaluation, and safety assessment of mesoporous silica nanoparticles loaded with prothioconazole against crop pathogens. In ENVIRONMENTAL SCIENCE-NANO, 2022, vol. 9, no. 7, pp. 2548-2558. ISSN 2051-8153. Dostupné na: https://doi.org/10.1039/d2en00226d.

KORNILOVA, A. A. - ZHAPBASOV, R. Zh. - ZHOMARTOV, A. M. - SIBATAEV, A. K. - BEGIMBETOVA, D. A. - BEKMANOV, B. O. Genotoxic Effect of Unused and Banned Pesticides on the Body of Cattle Kept on the Territory of South Kazakhstan. In CONTEMPORARY PROBLEMS OF ECOLOGY, 2022, vol. 15, no. 2, pp. 180-187. ISSN 1995-4255. Dostupné na: https://doi.org/10.1134/S1995425522020044.

RAFIKA, Debabsa - NEDJOUD, Grara - FADILA, Khaldi - HANA, Bouzahouane - NOUREDDINE, Guezgouz - ABDELHAK, Gheid. TOXICITY OF TWO PESTICIDES(SEKATOR AND PROSARO EC 250) INDUCED ALTERATIONS IN LIVER HISTOPHYSIOLOGICAL AND BIOCHEMICAL MARKERS IN MALE RABBITS(Otyctolagus Cuniculus). In FRESENIUS ENVIRONMENTAL BULLETIN, 2022, vol. 31, no. 8B, pp. 8968-8974. ISSN 1018-4619.

TRENTO, M.V.C. - CESAR, P.H.S. - MACHADO, G.H.A. - BRAGA, M.A. - DE ABREU, T.S. - ANDRADE-VIEIRA, L.F. - MARCUSSI, S. In vitro toxicological prospection of fungicides containing Difenoconazole Tit lo m port guesor Tebuconazole as active ingredients. In Acta Biologica Paranaense. ISSN 0301-2123, 2022, vol. 51, art. no. e84716.

GOLIANOVA, Katarina - HAVADEJ, Samuel - VEREBOVA, Valeria - ULICNY, Jozef - HOLECKOVA, Beata - STANICOVA, Jana. Interaction of Conazole Pesticides Epoxiconazole and Prothioconazole with Human and Bovine Serum Albumin Studied Using Spectroscopic Methods and Molecular Modeling. In INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, vol. 22, no. 4, pp.

MACAR, Oksal. Multiple toxic effects of tetraconazole in Allium cepa L. meristematic cells. In ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH. ISSN 0944-1344, 2021, vol. 28, no. 8, pp. 10092-10099.

SHEN, Jie - LIU, Peng - SUN, Yongqi - XU, Xiaoxiao - GUO, Longfei - RAO, Qiong - CHEN, Minlan - LIU, Xunyue. Embryonic exposure to prothioconazole induces oxidative stress and apoptosis in zebrafish (Danio rerio) early life stage. In SCIENCE OF THE TOTAL ENVIRONMENT. ISSN 0048-9697, 2021, vol. 756, no., pp.

BEN OTHMENE, Yosra - HAMDI, Hiba - ANNABI, Emna - AMARA, Ines - BEN SALEM, Intidhar - NEFFATI, Fadwa - NAJJAR, Mohamed Fadhel - ABID-ESSEFI, Salwa. Tebuconazole induced cardiotoxicity in male adult rat. In FOOD AND CHEMICAL TOXICOLOGY. ISSN 0278-6915, 2020, vol. 137, no., pp.

BEN OTHMENE, Yosra - HAMDI, Hiba - BEN SALEM, Intidhar - ANNABI, Emna - AMARA, Ines - NEFFATI, Fadwa - NAJJAR, Mohamed Fadhel - ABID-ESSEFI, Salwa. Oxidative stress, DNA damage and apoptosis induced by tebuconazole in the kidney of male Wistar rat. In CHEMICO-BIOLOGICAL INTERACTIONS. ISSN 0009-2797, 2020, vol. 330, no., pp.

BEN OTHMENE, Yosra - MONCEAUX, Kevin - KAROUI, Ahmed - BEN SALEM, Intidhar - BELHADEF, Anissa - ABID-ESSEFI, Salwa - LEMAIRE, Christophe. Tebuconazole induces ROS-dependent cardiac cell toxicity by activating DNA damage and mitochondrial apoptotic pathway. In ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. ISSN 0147-6513, 2020, vol. 204, no., pp.

FERRE, Daniela M. - JOTALLAN, Paola J. - LENTINI, Valeria - LUDUENA, Hector R. - ROMANO, Raquel R. - GORLA, Nora B. M. Biomonitoring of the hematological, biochemical and genotoxic effects of the mixture cypermethrin plus chlorpyrifos applications in bovines. In SCIENCE OF THE TOTAL ENVIRONMENT. ISSN 0048-9697, 2020, vol. 726, no., pp.

MONGER, Andrea - MATHEA, Miriam - ACHENBACH, Janosch H. - WOLFE, Antje - BUESEN, Roland - SCHLEIFER, Klaus-Juergen - LANDSIEDEL, Robert - VOLKAMER, Andrea. KnowTox: pipeline and case study for confident prediction of potential toxic effects of compounds in early phases of development. In JOURNAL OF CHEMINFORMATICS. ISSN 1758-2946, 2020, vol. 12, no. 1, pp.

TIAN, Sinuo - TENG, Miaomiao - MENG, Zhiyuan - YAN, Sen - JIA, Ming - LI, Ruisheng - LIU, Li - YAN, Jin - ZHOU, Zhiqiang - ZHU, Wentao. Toxicity effects in zebrafish embryos (Danio rerio) induced by prothioconazole. In ENVIRONMENTAL POLLUTION. ISSN 0269-7491, 2019, vol. 255, no., pp.