Programmed cell death alterations mediated by synthetic indole chalcone resulted in cell cycle arrest, DNA damage, apoptosis and signaling pathway modulations in breast cancer model

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Bibliographic information

Publication year
2022
Category
V3 — Scientific output of publication activity from the journal
CREPČ / EPCA ID
0046928
Document type
Journal article
Source
Pharmaceutics
ISSN (Source)
1999-4923
Volume
Vol. 14, no. 3 (2022), art. no. 503, p. [1-30]
Output type
article
Language
English
Study field
pharmacyField group: Health sciences and fields aimed at improving the quality of life
Research areas
120 — Chemistry, chemical technology and biotechnology
Links

Bibliographic record

MICHALKOVÁ, Radka - KELLO, Martin - KUDLIČKOVÁ, Zuzana - GAZDOVÁ, Mária - MIROSSAY, Ladislav - MOJŽIŠOVÁ, Gabriela - MOJŽIŠ, Ján. Programmed cell death alterations mediated by synthetic indole chalcone resulted in cell cycle arrest, DNA damage, apoptosis and signaling pathway modulations in breast cancer model. In: Pharmaceutics. 2022. ISSN 1999-4923, Vol. 14, no. 3 (2022), art. no. 503, p. [1-30]. (2022: 5.4 - IF, 85 - H-index, 6 - IF 5y, 0.795 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q, 0.754 - ABDC).

Publication authors

AuthorRoleShare
Radka MichalkováAuthor40.000 %
Martin KelloAuthor30.000 %
Zuzana KudličkováAuthor5.000 %
Mária GazdováAuthor5.000 %
Ladislav MirossayAuthor5.000 %
Gabriela MojžišováAuthor5.000 %
Ján MojžišAuthor10.000 %

Metrics

IF 5.4IF5 6SJR Q 1JCR Q 1SJR 0.795H-index 85ABDC 0.754Metrics year 2022

Citations (12)

Citation year / CategoryCitationsSource
2026
1

GAUR, Aysha - HSIEH, Ming Fa - PEERZADA, Mudasir Nabi - ALI, Imran - AZAM, Amir. Synthesis, Biological Evaluation, and In Silico ADMET Screening of Indole Embedded Sulfonamides as Anticancer Agents. In CHEMISTRYSELECT, 2026, vol. 11, no. 1, pp. ISSN 2365-6549. Dostupné na: https://doi.org/10.1002/slct.202500356.

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2026
1

GONG, Jingjing - LI, Qingqing - LIN, Mei - XU, Changsheng - CHAI, Dajun - LIN, Jinxiu - PENG, Feng. ACE2 ameliorates DOX-induced cardiotoxicity by suppressing excessive autophagy via the AMPK/mTOR signaling pathway. In BIOCHEMICAL PHARMACOLOGY, 2026, vol. 251, no., pp. ISSN 0006-2952. Dostupné na: https://doi.org/10.1016/j.bcp.2026.118119.

WOS
2026
1

IBRAHIM, Nada S. - HARIDY, Aisha Bahy - ELWAHY, Ahmed H. M. - SHARAKY, Marwa - DIAB, Hadeer M. - ABDELMONIEM, Amr M. - KELANY, Ayda K. - ABDELHAMID, Ismail A. Cytotoxicity, anti-proliferative, anti-inflammatory, anti-metastatic, and oxidative stress activities of novel cyanochalcones: Induction of apoptosis in HCT-116 cells. In JOURNAL OF MOLECULAR STRUCTURE, 2026, vol. 1369, no., pp. ISSN 0022-2860. Dostupné na: https://doi.org/10.1016/j.molstruc.2026.146315.

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2026
1

IBRAHIM, Nada S. - WALYELDEEN, Amr Ahmed - IBRAHIM, Sherif Abdelaziz - ABDELHAMID, Ismail A. - ELHAKIM, Heba K. A. Synthesis and cytotoxicity of novel cyanochalcones: induction of cell cycle arrest, apoptosis, and autophagy in HEP2 and MCF-7 cells. In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2026, vol. 399, no. 6, pp. 8867-8882. ISSN 0028-1298. Dostupné na: https://doi.org/10.1007/s00210-025-04940-z.

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2026
1

PASHIRZAD, Mehran - BUTLER, Alexandra E. - KESHARWANI, Prashant - SAHEBKAR, Amirhossein. Analysis of the clinicopathological relevance and prognostic value of CDK1 in human malignancy: Insights from meta and bioinformatics analysis. In SURGICAL ONCOLOGY-OXFORD, 2026, vol. 64, no., pp. ISSN 0960-7404. Dostupné na: https://doi.org/10.1016/j.suronc.2025.102339.

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2026
1

VALENZUELA-VALDERRAMA, Manuel - VARAS, Aranxa - RUBILAR, Mariaignacia - LORCA, Marcos - MELLA, Jaime - ESPINOSA-BUSTOS, Christian - MELLADO, Marco - ECHEVERRIA, Javier. 3D-QSAR study for the development of chalcone-based inhibitors targeting ovarian cancer cells with experimental validation. In FRONTIERS IN PHARMACOLOGY, 2026, vol. 17, no., pp. Dostupné na: https://doi.org/10.3389/fphar.2026.1746658.

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2026
1

WEI, Liping - SUN, Xinlu - DENG, Zisu - CHEN, Simei - HAN, Kexin - WEN, Lili - TAN, Liming - MIAO, Tingting. Per- and polyfluoroalkyl substances induce cytotoxicity in NCI-H446 cells through modulating proliferation, apoptosis, and mSUP6/SUPA methylation. In FOOD AND CHEMICAL TOXICOLOGY, 2026, vol. 208, no., pp. ISSN 0278-6915. Dostupné na: https://doi.org/10.1016/j.fct.2025.115868.

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2025
1

CHEN, Yuting - LIU, Yaxin - ZHOU, Jing - BAO, Tingting - WANG, Jing - AO, Mingtao. Adamantyl-Substituted Chalcone CA13 Induces Cytoprotective Autophagy and JNK-Dependent Apoptosis in Lung Cancer Cells. In BIOMOLECULES, 2025, vol. 16, no. 1, pp. Dostupné na: https://doi.org/10.3390/biom16010054.

WOS
2025
1

DE LA CRUZ-CANO, Eduardo - GONZALEZ-DIAZ, Jose angel - OLIVARES-CORICHI, Ivonne Maria - AYALA-SUMUANO, Jorge Tonatiuh - DIAZ-GANDARILLA, Jose Alfredo - TORRES-SAURET, Quirino - LARIOS-SERRATO, Violeta - VILCHIS-REYES, Miguel angel - LOPEZ-VICTORIO, Carlos Javier - GONZALEZ-GARRIDO, Jose Arnold - GARCIA-SANCHEZ, Jose Ruben. Identifying Genes Associated with the Anticancer Activity of a Fluorinated Chalcone in Triple-Negative Breast Cancer Cells Using Bioinformatics Tools. In INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, vol. 26, no. 8, pp. ISSN 1661-6596. Dostupné na: https://doi.org/10.3390/ijms26083662.

WOS
2025
1

GHANNAM, Iman A.Y. - ALI, Islam H. - BATRAN, Rasha Z. - ABO-ELFADL, Mahmoud T. - ALLAM, Rasha M. - IBRAHIM, Ibrahim M. - FAROUK, Faten. Investigating novel tubulin polymerization inhibitors: design, synthesis, LC/MS cellular permeability, in silico studies, and in vitro assessment. Dostupné na: https://doi.org/10.1007/s00044-024-03327-8. ISSN 10542523.

SCOPUS
2025
1

STRINGHETTA, Giulia Rodrigues - MASS, Eduardo Bustos - GOMES, Izabela Natalia Faria - PEIXOTO, Maria Clara Fonseca - TEJADA, Amanda Helena - SUSUCCHI, Luciane - BEZERRA, Aryel Jose Alves - RESENDE, Pedro Victor Silva - VENDRUSCULO, Vinicius - REIS, Manuel - RUSSOWSKY, Dennis - OLIVEIRA, Renato Jose Da Silva. Design, synthesis and evaluation of quinazoline-chalcone hybrids as inducers of cell-cycle arrest and apoptosis in breast cancer via DNA damage and CDK2/ATR inhibition. In EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS, 2025, vol. 13, no., pp. ISSN 2772-4174. Dostupné na: https://doi.org/10.1016/j.ejmcr.2025.100250.

WOS
2025
1

YUE, Hongshuang - FU, Yumei - FAN, Xiuyue - ZHOU, Fulin - LIU, Shu. The role and application potential of cytochrome c in breast cancer therapy. In DISCOVER ONCOLOGY, 2025, vol. 16, no. 1, pp. Dostupné na: https://doi.org/10.1007/s12672-025-03822-3.

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