| Basic data |
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| OCA1. Surname awarded to the assessed person | Nagy |
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| OCA2. Name awarded to the assessed person | Oskar |
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| OCA3. Degrees awarded to the assessed person | Prof. , DVM, PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/6036 |
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| OCA5. Area of assessment | study programme food hygiene · I. + II. degree |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2021 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | 424314 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioFormChildK28F&sid=948B46149DB3F1AF934543C564&seo=CREP%C4%8C-detail-%C4%8Cl%C3%A1nok |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://www.webofscience.com/wos/woscc/full-record/WOS:000702507500001 |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | ADC TÓTHOVÁ, Csilla [40 %] - NAGY, Oskar [20 %] - NOVOTNÝ, Jaroslav [4 %] - VDOVIAKOVÁ, Katarína [4 %] - KREŠÁKOVÁ, Lenka [4 %] - DANKO, Ján [3 %] - ŽERT, Zdeněk [5 %] - MEDVECKÝ, Ľubomír [5 %] - PETROVOVÁ, Eva [15 %]. The effect of the repair of induced articular cartilage defects in pigs using calcium phosphate cement with aminoacids on the concentrations of selected inflammatory markers and serum enzyme activities. In Symmetry. ISSN 2073-8994, 2021, vol. 13, no. 9, art. no. 1720, p. [1-10]. (2020: 2.713 - IF, 2.612 - IF 5y, Q2 - JCR Best Q). |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://www.mdpi.com/2073-8994/13/9/1720/htm |
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| OCA14. Characteristics of the author's contribution | The author is the bearer of the main ideas and co-creator of the output. At the same time, he is also the bearer of part of the financial resources of the projects from which the output was realized. |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | SAA, Hp, CRP and pig-MAP concentrations showed statistically significant dynamics of changes during the perioperative period. SAA concentrations were very low before surgery and increased significantly (approximately 100-fold on average) 7 days after surgery. In the further postoperative period, its values gradually decreased until the 30th day after surgery. In the case of Hp concentrations, a significant increase (approximately 4-fold) was observed 7 days after surgery compared to the values recorded before surgery. Its values decreased only slightly 14 days after surgery; however, they were still significantly higher than the preoperative values. A significant decrease in values was achieved 30 days after surgery compared to the values 7 days after surgery. A similar trend of a significant increase 7 days after surgery (approximately 3-fold) was also observed for CRP concentrations. From day 14 after surgery, a gradual non-significant decrease was observed until day 30 after surgery. Similarly, pigMAP concentrations significantly increased (almost 3-fold) 7 days after surgery. Its values showed a gradual decrease from day 14 after surgery, and the concentrations recorded 30 days after surgery were significantly lower compared to those obtained 7 days after cartilage repair. No significant changes were observed in AGP values during the evaluated perioperative period. |
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| Other data |
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| OCA16. Annotation of the output in English | The repair of articular cartilage defects is an intensively developing area of research. Severe inflammatory reactions after surgical interventions on bones or their structures may lead to changes of bone or joint asymmetry. In laboratory diagnostics, some inflammatory biomarkers and serum enzymes are available for the evaluation of these inflammatory processes. A general understanding of inflammatory responses following the repair of cartilage defects is still lacking. The aim of this study was to describe the alterations in the values of five inflammatory markers and the activities of several enzymes in seven 5-month-old pigs within the first 30 days following the restoration of induced articular cartilage defects using the tetracalcium phosphate/nanomoneite cement powder enriched with amino acids (CAL). The reconstruction of surgically induced defects was accompanied by a significant increase of serum amyloid A (SAA, p < 0.05), haptoglobin (Hp, p < 0.001), C-reactive protein (CRP, p < 0.01), and pig major acute phase protein (pig-MAP, p < 0.001). Their concentrations decreased gradually within one-month post-surgery, the values recorded at the end of this period were higher than those obtained prior to surgery. The concentrations of α1-acid glycoprotein (AGP) showed no significant changes during the evaluated period. . |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | [1]/[1] ELGHARBAWY, Hani - HASSONA, Aya - A․ EID, Mohamad - MORSY, Reda. Synthesis and biophysical characterization of porous bi-phase calcium phosphate/gelatin-PVA scaffold: Enhanced antibacterial, osteoconductivity and anticancer activity via silver nanoparticles and methotrexate incorporation. In Journal of Molecular Structure, 2024-09-05, 1311, pp. ISSN 00222860. Dostupné na: https://doi.org/10.1016/j.molstruc.2024.138329., Registrované v: WOS, SCOPUS |
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| OCA18. Characteristics of the output's impact on socio-economic practice | In the present study, the data indicate significant changes in the concentrations of SAA, Hp, CRP, as well as pig-MAP after reconstruction of surgically created articular cartilage defects with CAL cement. The results showed a significant increase in the values 7 days after surgery and a subsequent gradual decrease until the end of the one-month postoperative period. However, the values recorded at the end of this period were higher compared to the values obtained before surgery. No significant changes were observed in the concentrations of AGP in pigs during the evaluated perioperative period, which is less suitable for monitoring the period after cartilage defect repair. Changes were also found in the activities of CK and LD, increasing 7 days after surgery and then gradually decreasing. The activity of AP decreased after surgery and started to increase until the end of the evaluated period. The presented findings suggest that SAA, Hp, CRP and pig-MAP could be useful biomarkers of the acute phase response for monitoring the postoperative period after repair of articular cartilage defects using calcium phosphate biocement powders. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | The outputs are applicable in the educational process. |
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