ADC : Formetanate toxicity and changes in antioxidant enzyme system of Apis mellifera larvae = Toxicita formetanatu a zmeny antioxidačného enzýmového systému u včely medonosnej / Staroň Martin, Sabo Rastislav, Sobeková Anna, Sabová Lucia, Legáth Jaroslav, Lohajová Ľuboslava, Javorský Peter, 2017. In: Environmental Science and Pollution Research. - ISSN 0944-1344. - Vol. 24, č. 16(2017), s. 14060–14070.

Basic data
OCA1. Surname awarded to the assessed person	Legáth
OCA2. Name awarded to the assessed person	Jaroslav
OCA3. Degrees awarded to the assessed person	Prof. , DVM, CSc.
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/2269
OCA5. Area of assessment	study programme animal hygiene and environment · III. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2017
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	UVL.Košice.0027322
OCA9. Hyperlink to the record in CRPA or CRAA	http://www.crepc.sk/portal?fn=*recview&uid=2207130&pageId=resultform&full=0
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://www.ncbi.nlm.nih.gov/pubmed/28409431
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADC : Formetanate toxicity and changes in antioxidant enzyme system of Apis mellifera larvae = Toxicita formetanatu a zmeny antioxidačného enzýmového systému u včely medonosnej / Staroň Martin, Sabo Rastislav, Sobeková Anna, Sabová Lucia, Legáth Jaroslav, Lohajová Ľuboslava, Javorský Peter, 2017. In: Environmental Science and Pollution Research. - ISSN 0944-1344. - Vol. 24, č. 16(2017), s. 14060–14070.
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://pubmed.ncbi.nlm.nih.gov/28409431/
OCA14. Characteristics of the author's contribution	Coordinator of the scientific team.
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.
Other data
OCA16. Annotation of the output in English	Substantial percentage of world food production depends on pollinating service of honeybees that directly depends on their health status. Among other factors, the success of bee colonies depends on health of developed larvae. The crucial phase of larval development is the first 6 days after hatching when a worker larva grows exponentially and larvae are potentially exposed to xenobiotics via diet. In the present study, we determined the lethal concentration LC50 (72 h) following single dietary exposure of honeybee larvae to formetanate under laboratory conditions, being also the first report available in scientific literature. Activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) were also measured in the homogenates of in vitro reared honeybee larvae after single formetanate exposure. Decreased specific activity of SOD and increased activities of CAT and GST suggest the induction of oxidative stress. Higher levels of thiobarbituric reactive species in all samples supported this fact. Comparing determined larval toxicity (LC50 of 206.01 mg a.i./kg diet) with adult toxicity data, we can suppose that the larvae may be less sensitive to formetanate than the adult bees.
OCA17. List of maximum 5 most significant citations corresponding to the output	DAI, Pingli - JACK, Cameron J. - MORTENSEN, Ashley N. - ELLIS, James D. Acute toxicity of five pesticides to Apis mellifera larvae reared in vitro. In PEST MANAGEMENT SCIENCE. ISSN 1526-498X, 2017, vol. 73, no. 11, pp. 2282-2286., Registrované v: WoS [1] DAI, Pingli - YAN, Zhenxiong - MA, Shilong - YANG, Yang - WANG, Qiang - HOU, Chunsheng - WU, Yanyan - LIU, Yongjun - DIAO, Qingyun. The Herbicide Glyphosate Negatively Affects Midgut Bacterial Communities and Survival of Honey Bee during Larvae Reared in Vitro. In JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. ISSN 0021-8561, 2018, vol. 66, no. 29, pp. 7786-7793., Registrované v: WoS DAI, Pingli - JACK, Cameron J. - MORTENSEN, Ashley N. - BUSTAMANTE, Tomas A. - BLOOMQUIST, Jeffrey R. - ELLIS, James D. Chronic toxicity of clothianidin, imidacloprid, chlorpyrifos, and dimethoate to Apis mellifera L. larvae reared in vitro. In Pest Management Science. ISSN 1526498X, 2018-01-01, pp., Registrované v: WoS SANTOS, Helvécio M. - LOPES, Karina C. - ALVES, Dejane S. - CARVALHO, Geraldo A. - OLIVEIRA, Denilson F. Ursolic acid and cis-tiliroside produced by Merremia tomentosa affect oviposition of Leucoptera coffeella on coffee plants. In Quimica Nova. ISSN 01004042, 2018-03-01, 41, 3, pp. 302-309., Registrované v: WoS DAI, Pingli - JACK, Cameron J. - MORTENSEN, Ashley N. - BLOOMQUIST, Jeffrey R. - ELLIS, James D. The impacts of chlorothalonil and diflubenzuron on Apis mellifera L. larvae reared in vitro. In Ecotoxicology and Environmental Safety. ISSN 01476513, 2018-11-30, 164, pp. 283-288., Registrované v: Scopus
OCA18. Characteristics of the output's impact on socio-economic practice	The issue of pollinators and the use of pesticides in agriculture has recently been an extremely sedentary issue not only in the EU but throughout the world. Therefore, monitoring the impact of plant protection products on bees and their fetuses is extremely important. Development of new methodologies at the molecular level, monitoring of enzymes in larvae is the basis for better risk assessment of chemicals for hives.
OCA19. Characteristics of the output and related activities' impact on the educational process