ONDREJKOVÁ, Anna - SÜLI, Judit - HARVANOVÁ, Jarmila - ONDREJKA, Róbert - PROKEŠ, Marián. Antioxidative Protection of Squalene Adjuvant and Rabies Vaccine with Adjuvant. In Biological and Pharmaceutical Bulletin. ISSN 0918-6158, 2017, vol. 40, č. 7, s. 1029-1034. (2017: 1.694 - IF, 1.766 - IF 5y, 104 - H-index, 0.626 - SJR, Q2 - SJR Best Q, Q4

ONDREJKOVÁ, Anna - SÜLI, Judit - HARVANOVÁ, Jarmila - ONDREJKA, Róbert - PROKEŠ, Marián. Antioxidative Protection of Squalene Adjuvant and Rabies Vaccine with Adjuvant. In Biological and Pharmaceutical Bulletin. ISSN 0918-6158, 2017, vol. 40, č. 7, s. 1029-1034. (2017: 1.694 - IF, 1.766 - IF 5y, 104 - H-index, 0.626 - SJR, Q2 - SJR Best Q, Q4 - JCR Best Q).

Basic data
OCA1. Surname awarded to the assessed person	Ondrejková
OCA2. Name awarded to the assessed person	Anna
OCA3. Degrees awarded to the assessed person	Prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/2007
OCA5. Area of assessment	study programme infectious diseases of animals · III. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2017
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	0027247
OCA9. Hyperlink to the record in CRPA or CRAA	http://www.crepc.sk/portal?fn=*recview&uid=2207123&pageId=resultform&full=0
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://www.webofscience.com/wos/woscc/full-record/WOS:000404670100011
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ONDREJKOVÁ, Anna - SÜLI, Judit - HARVANOVÁ, Jarmila - ONDREJKA, Róbert - PROKEŠ, Marián. Antioxidative Protection of Squalene Adjuvant and Rabies Vaccine with Adjuvant. In Biological and Pharmaceutical Bulletin. ISSN 0918-6158, 2017, vol. 40, č. 7, s. 1029-1034. (2017: 1.694 - IF, 1.766 - IF 5y, 104 - H-index, 0.626 - SJR, Q2 - SJR Best Q, Q4 - JCR Best Q).
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.jstage.jst.go.jp/article/bpb/40/7/40_b17-00026/_html/-char/en
OCA14. Characteristics of the author's contribution	50% - Experiment preparation, immunization of animals, blood collection, detection of specific antibodies
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	The study determined the influence of β-carotene on the stability and antigenic effectiveness of adjuvant emulsion in combination with rabies vaccine. While the inactivated rabies vaccine with adjuvant without β-carotene developed a rapid formation of rabies antibodies, the application of the vaccine with β-carotene induced a slower but more uniform production of antibodies. The level of rabies antibodies was significantly higher after the application of the vaccine with β-carotene and reached the protective value of 0.5 IU/mL.
Other data
OCA16. Annotation of the output in English	In the study of the in vitro system of the squalene adjuvants, α-tocopherol acted as a prooxidant, while β-carotene was able to effectively reduce the oxidative injury during all of the UV-irradiation doses used. The vaccine with β-carotene induced a gradual increase in the levels of rabies antibodies, with the highest antibody levels on day 28. While the inactivated rabies vaccine with adjuvant without β-carotene developed a rapid formation of rabies antibodies (on day 14), the application of vaccine with β carotene induced a slower but more uniform production of rabies antibodies. The level of rabies antibodies was significantly higher after application of the vaccine with β-carotene and, by contrast to the vaccine without β-carotene, the levels of antibodies reached the protective value of 0.5 IU/mL.
OCA17. List of maximum 5 most significant citations corresponding to the output	OTOMARU, Konosuke - OGAWA, Rei - OISHI, Shoko - IWAMOTO, Yuki - HONG, Hyeyoung - NAGAI, Kathuhisa - HYAKUTAKE, Koji - KUBOTA, Chikara - KANESHIGE, Takahiro. Effect of beta-carotene supplementation on the serum oxidative stress biomarker and antibody titer against live bovine respiratory syncytial virus vaccination in Japanese black calves. In Veterinary Sciences, 2018-12-01, 5, 4, pp., Registrované v: Scopus FISHER, C. R. - SCHNELL, M. J. New developments in rabies vaccination. In REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES. ISSN 0253-1933, 2018, vol. 37, no. 2, pp. 657-672., Registrované v: WoS SAKUL, Arzu - OZANSOY, Mehmet - ELIBOL, Birsen - AYLA, Şule - GÜNAL, Mehmet Yalçın - YOZGAT, Yasemin - BAŞAĞA, Hüveyda - ŞAHIN, Kazım - KAZANCIOĞLU, Rümeyza - KILIÇ, Ülkan. Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice. In Turkish Journal of Biology. ISSN 13000152, 2019-01-01, 43, 3, pp. 179-188., Registrované v: Scopus OTOMARU, K. - IWAMOTO, Y. - HONG, H.Y. - NAGAI, K. - KUBOTA, CH. - YAMAUCHI, S. - NOCHI, T. Effect of Beta-carotene on Fecal IgA in Japanese Black Calves. In Journal of the Japan Veterinary Medical Association. ISSN 2186-0211, 2019, vol. 72, no. 6, p. 344-347. WANG, Zongmei - YUAN, Yueming - CHEN, Chen - ZHANG, Chengguang - HUANG, Fei - ZHOU, Ming - CHEN, Huanchun - FU, Zhen F. - ZHAO, Ling. Colloidal Manganese Salt Improves the Efficacy of Rabies Vaccines in Mice, Cats, and Dogs. In JOURNAL OF VIROLOGY. ISSN 0022-538X, 2021, vol. 95, no. 23, pp., Registrované v: WoS
OCA18. Characteristics of the output's impact on socio-economic practice	The immunogenic and antigenic activity of vaccines is influenced by the addition of appropriate adjuvants and antioxidants to vaccines, thereby enhancing their effect. In this study, the effect of β-carotene on the stability and antigenic efficacy of an adjuvanted emulsion in combination with rabies vaccine was investigated. The results have significant implications for the pharmaceutical industry; they are applicable in animal clinical practice. Nowadays, the preparation and utilization of suitable adjuvants and antioxidants has an irreplaceable place in vaccine production.
OCA19. Characteristics of the output and related activities' impact on the educational process	The present work was aimed at influencing the immunogenic and antigenic activity of vaccines by adding appropriate adjuvants and antioxidants thereby enhancing their effect. In this study, the effect of β-carotene on the stability and antigenic efficacy of an adjuvanted emulsion in combination with rabies vaccine was investigated. The obtained results are used in the study of immunology, epidemiology and immunoprophylaxis of infectious diseases in animals.