| Basic data |
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| OCA1. Surname awarded to the assessed person | Sopková |
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| OCA2. Name awarded to the assessed person | Drahomíra |
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| OCA3. Degrees awarded to the assessed person | Assoc. prof. , DVM, PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/6022 |
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| OCA5. Area of assessment | study programme veterinary morphology and physiology · III. degree |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2018 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | ID = 101015 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioForm&sid=849D4996E9A7E8D3AA7C53129D |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://pubmed.ncbi.nlm.nih.gov/29685707/ |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | ADC VLČKOVÁ, Radoslava - ANDREJČÁKOVÁ, Zuzana - SOPKOVÁ, Drahomíra - HERTELYOVÁ, Zdenka - KOZIOŁ, Katarzyna - KOZIOROWSKI, Marek - GANCARČÍKOVÁ, Soňa. Supplemental flaxseed modulates ovarian functions of weanling gilts via the action of selected fatty acids. In Animal Reproduction Science. ISSN 0378-4320, 2018, vol. 193, s. 171-181. (2018: 1.817 - IF, 1.998 - IF 5y, 98 - H-index, 0.622 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q). |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://doi.org/10.1016/j.anireprosci.2018.04.066 |
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| OCA14. Characteristics of the author's contribution | Preparation of the experiment, sampling, analysis of polyunsaturated fatty acids. |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | The aim of this study was to examine the influence of dietary flaxseed on the endocrine and ovarian functions of weanling gilts challenged with E. coli and Coronavirus infections treated with dietary probiotic cheeses and to understand the possible mechanisms of its effects on ovarian function. Probiotics were used as a natural substitution for antibiotics and 10% dietary flaxseed is an effective prebiotic which supports the action of probiotics and has other beneficial effects on the organism. Probiotics with or without flaxseed were fed to weanling gilts starting 10 days before and lasting up until 14 days after weaning. The ovaries were measured and histologically analysed. The blood samples for the levels of steroid hormones and insulin-like growth factor I (IGF-I) were assessed using immunoassays and the levels of fatty acids were assessed using gas chromatography. All samples were collected on the day of weaning and 14 days after weaning. On the day of weaning, increased levels of linoleic acid and IGF-I was associated with higher body weight. The steroid hormones were not affected by the diet. The conversion of alpha-linolenic acid (ALA) to timodonic (EPA) and cervonic (DHA) acids were lower compared to controls, and together with high levels of myristic, palmitic and palmitoleic acids was associated with the higher proliferation and lower apoptosis in the primordial, primary and secondary follicles; although the inhibition of the cell cycle was observed in relation to the low level of eicosadienoic acid. The high levels of ALA, EPA and DHA and the low levels of myristic, palmitic and palmitoleic acids may have been the effect of flaxseed feeding 14 days post-weaning and may have had a reverse effect on the proliferation and apoptosis of ovarian follicles. These data suggest that flaxseed may suppress the follicle development in weanlings via the stimulation of apoptosis and the inhibition of proliferation via the modulation of the metabolism of selected fatty acids. |
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| Other data |
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| OCA16. Annotation of the output in English | The aim of this study was to examine the influence of dietary flaxseed on the endocrine and ovarian functions of weanling gilts challenged with E. coli and Coronavirus infections treated with dietary probiotic cheeses and to understand the possible mechanisms of its effects on ovarian function. Probiotics were used as a natural substitution for antibiotics and 10% dietary flaxseed is an effective prebiotic which supports the action of probiotics and has other beneficial effects on the organism. Probiotics with or without flaxseed were fed to weanling gilts starting 10 days before and lasting up until 14 days after weaning. The ovaries were measured and histologically analysed. The blood samples for the levels of steroid hormones and insulin-like growth factor I (IGF-I) were assessed using immunoassays and the levels of fatty acids were assessed using gas chromatography. All samples were collected on the day of weaning and 14 days after weaning. On the day of weaning, increased levels of linoleic acid and IGF-I was associated with higher body weight. The steroid hormones were not affected by the diet. The conversion of alpha-linolenic acid (ALA) to timodonic (EPA) and cervonic (DHA) acids were lower compared to controls, and together with high levels of myristic, palmitic and palmitoleic acids was associated with the higher proliferation and lower apoptosis in the primordial, primary and secondary follicles; although the inhibition of the cell cycle was observed in relation to the low level of eicosadienoic acid. The high levels of ALA, EPA and DHA and the low levels of myristic, palmitic and palmitoleic acids may have been the effect of flaxseed feeding 14 days post-weaning and may have had a reverse effect on the proliferation and apoptosis of ovarian follicles. These data suggest that flaxseed may suppress the follicle development in weanlings via the stimulation of apoptosis and the inhibition of proliferation via the modulation of the metabolism of selected fatty acids. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | POURJAFARI, Fahimeh - HAGHPANAH, Tahereh - SHARIFIFAR, Fariba - NEMATOLLAHI-MAHANI, Seyed Noreddin - AFGAR, Ali - KARAM, Gholamreza Asadi - EZZATABADIPOUR, Massood. Protective effects of hydro-alcoholic extract of foeniculum vulgare and linum usitatissimum on ovarian follicle reserve in the first-generation mouse pups. In HELIYON. ISSN 2405-8440, 2019, vol. 5, no. 10, pp., Registrované v/Registered in: WoS |
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| OCA18. Characteristics of the output's impact on socio-economic practice | Flaxseed is a suitable supplement to the dairy diet for piglets before weaning, supports their growth and proliferation of ovarian cells, while 2 weeks after weaning, the antiproliferative and proapoptotic effect of altering lipid metabolism is manifested in favor of n-3 PNMK. This inhibitory effect of flax on the ovarian function of young sows may result in a later onset of puberty. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | The results provide new insights into the effects of flaxseed on the ovarian functions of piglets, especially after weaning, when lipid and fatty acid metabolism is improved in favor of n-3 PUFAs, which can suppress folliculogenesis through the application of proapoptotic and antiproliferative effects. |
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