ADC Effect of humic acids on lead poisoning in bones and on a subcellular level in mitochondria. Vašková, JankaVaško, LadislavMudroň, PavolHaus, MartinŽatko, DanielKrempaská, KláraStupák, Marek. In Environmental Science and Pollution Research, 2020, Roč. 27, č. 32, s. 40679-40689

Basic data
OCA1. Surname awarded to the assessed person	Mudroň
OCA2. Name awarded to the assessed person	Pavol
OCA3. Degrees awarded to the assessed person	Prof. , DVM, PhD, Dip. ECBHM
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6004
OCA5. Area of assessment	study programme internal diseases of animals · III. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2020
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	212897
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=31B81341D84CFED63ACAB2027B
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://pubmed.ncbi.nlm.nih.gov/32671699/
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADC Effect of humic acids on lead poisoning in bones and on a subcellular level in mitochondria. Vašková, JankaVaško, LadislavMudroň, PavolHaus, MartinŽatko, DanielKrempaská, KláraStupák, Marek. In Environmental Science and Pollution Research, 2020, Roč. 27, č. 32, s. 40679-40689
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://link.springer.com/article/10.1007/s11356-020-10075-w
OCA14. Characteristics of the author's contribution	The author is the bearer of partial ideas and co-author of the output. At the same time, he is also the holder of partial financial resources for projects from which the output was implemented.
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	The aim of this study is to add to the current knowledge on the chelating effects of humic acids (HA) in chronic lead intoxication in rat organs. Lead acetate trihydrate was administered to rats for 5 weeks at a daily dose of 155.5 mg/kg body weight. Three concentrations of HA were administered simultaneously to the rats and the effect was measured over the following 5 weeks. Increased Pb concentrations were detected in the femur after the first week, whereas the HA-treated groups showed a tendency to inhibit the increase in Pb deposition. After 5 weeks, Pb concentrations in the HA groups decreased significantly. At the same time, however, other elements were redistributed, with a particularly notable decrease in Se and Zn. While an increase in Pb concentrations was detected after 5 weeks of Pb administration, the 1% HA concentration resulted in the least significant increase in Pb as well as an increase/decrease in Se/Cu. At the end of the experiment, again in the 1% HA group, Pb concentrations remained higher only in the liver, whereas the other elements were sufficiently normalized, suggesting that this concentration is useful in the treatment of Pb intoxication.
Other data
OCA16. Annotation of the output in English	This study aims to supplement the current knowledge on the chelating effects of humic acids (HA) in chronic lead intoxication in rat organs. Lead acetate trihydrate was administered to rats for 5 weeks at a daily dose of 155.5 mg/kg body weight. At the same time, rats were given three concentrations of HA, with their effect measured over the following 5 weeks. Increased Pb concentrations were detected in the femur after the first week, while HA-administered groups showed a tendency towards inhibiting the increase in Pb deposition. After 5 weeks, Pb concentrations dropped significantly in the HA groups. At the same time, however, other elements were redistributed, with a decrease in Se and Zn being particularly noteworthy. While an increase in Pb concentrations was found after 5 weeks of Pb administration, a concentration of 1% HA resulted in the least significant increase in Pb as well as an increase/decrease in Se/Cu, respectively. At the end of the experiment, again in the 1% HA group, Pb concentrations remained higher only in the liver with the other elements sufficiently normalized, indicating this concentration to be useful in the treatment of Pb intoxication.
OCA17. List of maximum 5 most significant citations corresponding to the output
OCA18. Characteristics of the output's impact on socio-economic practice	The output of the study is focused on gaining basic knowledge about the detoxification properties of humic acids, which are increasingly used as an additive in animal production (eg feed rations of dairy cows).
OCA19. Characteristics of the output and related activities' impact on the educational process	The output of the study is used in the teaching of Diseases of ruminants and Herd Health Management.