| Basic data |
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| OCA1. Surname awarded to the assessed person | Legáth |
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| OCA2. Name awarded to the assessed person | Jaroslav |
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| OCA3. Degrees awarded to the assessed person | Prof. , DVM, CSc. |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/2269 |
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| OCA5. Area of assessment | study programme pharmacy (joint study programme) · I. + II. degree |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2020 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | 205776 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioFormChildQF52&sid=574F17740F99520832A6A15599&seo=CREP%C4%8C-detail-%C4%8Cl%C3%A1nok |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://www.webofscience.com/wos/woscc/full-record/WOS:000564068800001 |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | ADM Evaluation of antifungal activity of Naja pallida and Naja mossambica venoms against three candida species / Ewelina Kuna, Aleksandra Bocian, Konrad Kamil Hus, Vladimír Petrilla, Monika Petrillová, Jaroslav Legáth, Anna Lewinska, Maciej Wnuk. In Toxins. - ISSN 2072-6651. - Vol. 12, no. 8 (2020), art. no. 500, p. [1-17]. (2019: 3.531 - IF, 3.832 - IF 5y, 66 - H-index, 1.034 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q). |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://www.mdpi.com/2072-6651/12/8/500/htm |
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| OCA14. Characteristics of the author's contribution | |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | |
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| Other data |
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| OCA16. Annotation of the output in English | In contrast to comprehensively investigated antibacterial activity of snake venoms, namely crude venoms and their selected components, little is known about antifungal properties of elapid snake venoms. In the present study, the proteome of two venoms of red spitting cobraNaja pallida(NPV) and Mozambique spitting cobraNaja mossambica(NMV) was characterized using LC-MS/MS approach, and the antifungal activity of crude venoms against threeCandidaspecies was established. A complex response to venom treatment was revealed. NPV and NMV, when used at relatively high concentrations, decreased cell viability ofC. albicansandC. tropicalis, affected cell cycle ofC. albicans, inhibitedC. tropicalis-based biofilm formation and promoted oxidative stress inC. albicans,C. glabrataandC. tropicaliscells. NPV and NMV also modulated ammonia pulses during colony development and aging in threeCandidaspecies. All these observations provide evidence that NPV and NMV may diminish selected pathogenic features ofCandidaspecies. However, NPV and NMV also promoted the secretion of extracellular phospholipases that may facilitateCandidapathogenicity and limit their usefulness as anti-candidal agents. In conclusion, antifungal activity of snake venoms should be studied with great caution and a plethora of pathogenic biomarkers should be considered in the future experiments. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | Chérifi, F., Laraba-Djebari, F.Bioactive Molecules Derived from Snake Venoms with Therapeutic Potential for the Treatment of Thrombo-Cardiovascular Disorders Associated with COVID-19(2021) Protein Journal, 40 (6), pp. 799-841 2. Wnuk, M., Lewinska, A.Imaging flow cytometry-based analysis of bacterial profiles in milk samples(2021) Food and Bioproducts Processing, 128, pp. 102-108 3. Lee, G.Drug development using natural toxins(2021) Toxins, 13 (6), art. no. 414
Wnuk, M., Lewinska, A.Imaging flow cytometry-based analysis of bacterial profiles in milk samples(2021) Food and Bioproducts Processing, 128, pp. 102-108
Lee, G.Drug development using natural toxins(2021) Toxins, 13 (6), art. no. 414 |
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| OCA18. Characteristics of the output's impact on socio-economic practice | |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | |
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