ADC Polyphenols content, antioxidant activity, and cytotoxicity assessment of Taraxacum officinale extracts prepared through the micelle-mediated extraction method / Michal Milek, Dana Marcinčáková, Jaroslav Legáth. In Molecules. - ISSN 1420-3049. - Vol. 24, no. 6 (2019), art. no. 1025, p. [1-14]. (2019).

Basic data
OCA1. Surname awarded to the assessed person	Legáth
OCA2. Name awarded to the assessed person	Jaroslav
OCA3. Degrees awarded to the assessed person	Prof. , DVM, CSc.
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/2269
OCA5. Area of assessment	study programme pharmacy (joint study programme) · I. + II. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2019
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	125428
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioFormChildK74S&sid=F2C5C64D9C64B04EA7772133DE&seo=CREP%C4%8C-detail-%C4%8Cl%C3%A1nok
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://www.webofscience.com/wos/woscc/full-record/WOS:000464290200002
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADC Polyphenols content, antioxidant activity, and cytotoxicity assessment of Taraxacum officinale extracts prepared through the micelle-mediated extraction method / Michal Milek, Dana Marcinčáková, Jaroslav Legáth. In Molecules. - ISSN 1420-3049. - Vol. 24, no. 6 (2019), art. no. 1025, p. [1-14]. (2019).
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.mdpi.com/1420-3049/24/6/1025/htm
OCA14. Characteristics of the author's contribution
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.
Other data
OCA16. Annotation of the output in English	This experiment was conducted with extracts prepared from dandelion (Taraxacum officinale F. H. Wigg) leaves and flowers, using the micelle-mediated extraction method, with the surface active compound Triton X-100 and water-acetone as the extraction solvents. Extracts were, first, examined for the content of total phenols and the antioxidant capacity. All extracts showed good anti-radical properties, especially for leaves, in comparison to the flower samples. Flavonoids (mainly luteolin derivatives) and phenolic acids, predominated among the determined polyphenols. Quantitative analyses indicated acetone extract to be the richest in phenols (up to 0.535 mg/mL), in the case of dandelion leaves, and Triton X-100 extract in the case of flowers (0.385 mg/mL). Extracts were also evaluated for cytotoxicity to the model cell line (epithelial rabbit kidney cells RK13), using the colorimetric 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) test and the real-time cell analysis method ((RTCA); xCELLigence system). The obtained results indicated that surfactants, especially non-ionic ones, can be effectively used as modifiers in the aqueous extraction of phenolic compounds from plant materials. An advantage over the traditional organic solvents is their non-flammability. Furthermore, surfactants might also be used at low concentrations. Studies on cell lines, however, indicated the cytotoxic effect of this type of compound, even in the trace amounts present in the extracts.
OCA17. List of maximum 5 most significant citations corresponding to the output	Li, Y., Chen, Y., Sun-Waterhouse, D.The potential of dandelion in the fight against gastrointestinal diseases: A review(2022) Journal of Ethnopharmacology, 293, art. no. 115272 Mostafavi, Z.S., Shekarabi, S.P.H., Mehrgan, M.S., Islami, H.R.Amelioration of growth performance, physio-metabolic responses, and antioxidant defense system in rainbow trout, Oncorhynchus mykiss, using dietary dandelion, Taraxacum officinale, flower extract(2022) Aquaculture, 546, art. no. 737296 Śliwa, P., Śliwa, K.Nanomicellar extraction of polyphenols—methodology and applications review(2021) International Journal of Molecular Sciences, 22 (21), art. no. 1392 Huang, L.-Y., Ning, H.-X., Yao, X.-C., Wang, S.-B., Hou, W.-B., Li, Y.-L.Research progress on extraction and purification(2021) Chinese Traditional and Herbal Drugs, 52 (4), pp. 1185-1192 Pfingstgraf, I.O., Taulescu, M., Pop, R.M., Orăsan, R., Vlase, L., Uifalean, A., Todea, D., Alexescu, T., Toma, C., Pârvu, A.E.Protective effects of taraxacum officinale l. (dandelion) root extract in experimental acute on chronic liver failure(2021) Antioxidants, 10 (4), art. no. 504
OCA18. Characteristics of the output's impact on socio-economic practice
OCA19. Characteristics of the output and related activities' impact on the educational process