ADC A study of 5-fluorouracil desorption from mesoporous silica by RP-UHPLC = Štúdium desorpcie 5-fluorouracilu z mezopórovej siliky pomocou RP-UHPLC / Monika Šuleková, Lucia Váhovská, Alexander Hudák, Lukáš Žid, Vladimír Zeleňák. In Molecules. - ISSN 1420-3049. - Vol. 24, no. 7(2019), art. no. 1317, p. [1-15]. (2019).

Basic data
OCA1. Surname awarded to the assessed person	Hudák
OCA2. Name awarded to the assessed person	Alexander
OCA3. Degrees awarded to the assessed person	Assoc. prof. , M.A., PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/15736
OCA5. Area of assessment	study programme pharmacy (joint study programme) · I. + II. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2019
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	121127
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioFormChildIT3F&sid=89B7BE4D03EE00FA73506CCD7F&seo=CREP%C4%8C-detail-%C4%8Cl%C3%A1nok
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://www.scopus.com/record/display.uri?eid=2-s2.0-85063748154&origin=resultslist&sort=plf-f&src=s&st1=Hud%c3%a1k+Alexander&sid=e0dd5da27bb2fcbdefb5fba63f9c532d&sot=b&sdt=b&sl=28&s=AUTHOR-NAME%28Hud%c3%a1k+Alexander%29&relpos=1&citeCnt=6&searchTerm=&featureToggles=FEATURE_NEW_DOC_DETAILS_EXPORT:1
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADC A study of 5-fluorouracil desorption from mesoporous silica by RP-UHPLC = Štúdium desorpcie 5-fluorouracilu z mezopórovej siliky pomocou RP-UHPLC / Monika Šuleková, Lucia Váhovská, Alexander Hudák, Lukáš Žid, Vladimír Zeleňák. In Molecules. - ISSN 1420-3049. - Vol. 24, no. 7(2019), art. no. 1317, p. [1-15]. (2019).
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.mdpi.com/1420-3049/24/7/1317
OCA14. Characteristics of the author's contribution
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.
Other data
OCA16. Annotation of the output in English	In cancer treatment, the safe delivery of the drug to the target tissue is an important task. 5-fluorouracil (5-FU), the well-known anticancer drug, was encapsulated into the pores of unmodified mesoporous silica SBA-15, as well as silica modified with 3-aminopropyl and cyclohexyl groups. The drug release studies were performed in two different media, in a simulated gastric fluid (pH = 2) and in a simulated body fluid (pH = 7) by RP-UHPLC. The simple and rapid RP-UHPLC method for quantitative determination of 5-fluorouracil released from unmodified and modified mesoporous silica SBA-15 was established on ODS Hypersil C18 column (150 × 4.6 mm, 5 µm) eluted with mobile phase consisted of methanol: phosphate buffer in volume ratio of 3:97 (v/v). Separation was achieved by isocratic elution. The flow rate was kept at 1 mL/min, the injection volume was set at 20 µL and the column oven temperature was maintained at 25 °C. The effluent was monitored at 268 nm. This paper provides information about the quantitative determination of the released 5-FU from silica. It was found out that larger amount of the drug was released in neutral pH in comparison with the acidic medium. In addition, surface functionalisation of silica SBA-15 influences the release properties of the drug.
OCA17. List of maximum 5 most significant citations corresponding to the output	Nguyen, P.T.H., Le, B.T., Ninh, H.D., La, D.D. Ultrasonic-Assisted Synthesis of Fe-BTC-PEG Metal-Organic Complex: An Effective and Safety Nanocarrier for Anticancer Drug Delivery. ACS Omega. 2021, 6(49), pp. 33419-33427. El Nahrawy, A.M., Abou Hammad, A.B., Mansour, A.M. Compositional Effects and Optical Properties of P2O5 Doped Magnesium Silicate Mesoporous Thin Films. Arabian Journal for Science and Engineering. 2021, 46(6), pp. 5893-5906. Simonetti, S., Grau, E.N., Roman, G., Ulacco, S. Comparative dft study of 5-fluorouracil adsorption on silica and gra-phene for bio-medical applications. Micro and Nanosystems. 2021, 13(3), pp. 246-252. Mohan, D., Khairullah, N.F., How, Y.P., Sajab, M.S., Kaco, H. 3D Printed Laminated CaCO3-Nanocellulose Films as Controlled-Release 5-Fluorouracil. Polymers. 2020, 12(4),986. Jampilek, J. Heterocycles in medicinal chemistry. Molecules. 2019, 24(21),3839.
OCA18. Characteristics of the output's impact on socio-economic practice
OCA19. Characteristics of the output and related activities' impact on the educational process