ADC BLAHOVEC, Ján - KOSTECKÁ, Zuzana - LACROIX, Marie Christine - CABANIÉ, Lucien - GODEAU, François - MEŠTER, Ján - CAVAILLE, Francoise. Mitogenic activity of high molecular weight forms of insulin-like growth factor-II in amniotic fluid. In Journal of Endocrinology. ISSN 0022-0795, 2001, vol. 169, č. 3, s. 563-572. (2001: 2.834 - IF, 138 - H-index, 1.031 - SJR, Q1 - SJR Best Q, Q2 - JCR Best Q).
| Basic data | |
|---|---|
| OCA1. Surname awarded to the assessed person | Kostecká |
| OCA2. Name awarded to the assessed person | Zuzana |
| OCA3. Degrees awarded to the assessed person | Assoc. prof. , DVM, PhD |
| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/6058 |
| OCA5. Area of assessment | study programme veterinary obstetrics and gynecology · III. degree |
| OCA6. Category of the research/artistic/other output | scientific output |
| OCA7. Year of publication of the research/artistic/other output | 2001 |
| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | |
| OCA9. Hyperlink to the record in CRPA or CRAA | |
| Characteristics of the output that is not registered in CRPA or CRAA | |
| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://www.webofscience.com/wos/woscc/full-record/WOS:000169190900016 |
| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | ADC BLAHOVEC, Ján - KOSTECKÁ, Zuzana - LACROIX, Marie Christine - CABANIÉ, Lucien - GODEAU, François - MEŠTER, Ján - CAVAILLE, Francoise. Mitogenic activity of high molecular weight forms of insulin-like growth factor-II in amniotic fluid. In Journal of Endocrinology. ISSN 0022-0795, 2001, vol. 169, č. 3, s. 563-572. (2001: 2.834 - IF, 138 - H-index, 1.031 - SJR, Q1 - SJR Best Q, Q2 - JCR Best Q). |
| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://joe.bioscientifica.com/view/journals/joe/169/3/563.xml |
| OCA14. Characteristics of the author's contribution | second author - 25 % |
| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | Amniotic fluid (AF) collected from ewes and goats at mid gestation displayed mitogenic activity in mouse fibroblasts. Upon fractionation of this material by size exclusion chromatography, the mitogenic activity was resolved into two peaks, whose activity was inhibited by an anti-IGF type 1 receptor blocking antibody. One of the peaks contained IGF-I and IGF-II (mature form), whereas the other contained high Mr precursor forms of IGF-II. The presence in this latter fraction of IGF-binding proteins (IGFBP) suggests that the AF IGFBPs do not efficiently inhibit the mitogenic activity of the high Mr forms of IGF-II. In agreement with this conclusion, exogenous IGFBP-1 failed to affect this activity. Analysis of IGF-II in sheep AF showed that the AF concentrations of both forms of IGF-II increased dramatically from mid pregnancy until 106–120 days of gestation, and fell thereafter. The amniotic IGFBPs followed a similar evolution. High Mr forms of IGF-II were also found in human AF, with a pattern of electrophoretic migration different from that of sheep. We suggest that the precursor forms of IGF-II may play an important role in foetal development. |
| Other data | |
| OCA16. Annotation of the output in English | In the work we studied the properties of mitogenic components present in sheep and goat amniotic fluid at 70 days of pregnancy, the time of the initiation of fast fetal growth in these animals. |
| OCA17. List of maximum 5 most significant citations corresponding to the output | DAVIES, S.B. - CHUI, J. - MADIGAN, M.C. - PROVIS, J.M. - WAKEFIELD, D. - DI GIROLAMO, N. Stem Cell Activity in the Developing Human Cornea. In STEM CELLS. ISSN 1066-5099, NOV 2009, vol. 27, no. 11, p. 2781-2792., Registrované v: WOS Duan, Y., Wang, C.-Y., Zhao, H., Zhang, Z.-F., Chen, J.-W., Sussenbach, J.S., Effective expression of human insulin like growth factor-2 in Bombyx mori larvae. In. Journal of China Pharmaceutical University, 2002, vol. 33, no 2, pp. 156-160., Registrované v: Scopus CHRISSOULI, Stefania - PRATSINIS, Harris - VELISSARIOU, Voula - ANASTASIOU, Anastasios - KLETSAS, Dimitris. Human amniotic fluid stimulates the proliferation of human fetal and adult skin fibroblasts: The roles of bFGF and PDGF and of the ERK and Akt signaling pathways. In WOUND REPAIR AND REGENERATION, 2010, vol.18, no.6, 643-654., Registrované v: WoS HARDOUIN, Sylvie Nathalie - GUO, Ruolin - ROMEO, Paul-Henri - NAGY, Andras - AUBIN, Jane E. Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts. In DEVELOPMENT, 2011, vol.138, no.2, 203-213., Registrované v: WoS LIAO, Ji - ZENG, Tie-Bo - PIERCE, Nicholas - TRAN, Diana A. - SINGH, Purnima - MANN, Jeffrey R. - SZABO, Piroska E. Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes. In CELL REPORTS. ISSN 2211-1247, 2021, vol. 34, no. 6, pp., Registrované v: WoS |
| OCA18. Characteristics of the output's impact on socio-economic practice | The work brought an international collaboration between UVMP and INSERM, France. It was further studied in the laboratories of both institutes. |
| OCA19. Characteristics of the output and related activities' impact on the educational process | The work brought knowledge in the area of cell proliferation mediated by insulin-like growth factors during embryogenesis. It will find its application in molecular biology of fetal development. |