ADC - Vedecké práce v zahraničných karentovaných časopisoch IF=3.929, Q1, citované 207x

Basic data
OCA1. Surname awarded to the assessed person	Mojžiš
OCA2. Name awarded to the assessed person	Ján
OCA3. Degrees awarded to the assessed person	Prof. , DVM, DrSc.
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/14977
OCA5. Area of assessment	study programme pharmacy (joint study programme) · I. + II. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2008
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	UPJŠ.Košice.000032036
OCA9. Hyperlink to the record in CRPA or CRAA	http://www.crepc.sk/portal?fn=*recview&uid=45496&pageId=resultform&full=0
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://www.webofscience.com/wos/woscc/full-record/WOS:000256201800002
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADC - Vedecké práce v zahraničných karentovaných časopisoch IF=3.929, Q1, citované 207x
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.sciencedirect.com/science/article/pii/S1043661808000364?via%3Dihub
OCA14. Characteristics of the author's contribution
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.
Other data
OCA16. Annotation of the output in English	Uncontrolled angiogenesis is a major contributor to a number of disease states. It is also considered a key step in tumour growth, invasion, and metastasis. Therefore, modulation of angiogenesis is considered as therapeutic strategies of great importance for human health. Numerous bioactive plant compounds are recently tested for their antiangiogenic potential. Among the most frequently studied are polyphenols present in fruits and vegetables. This review focuses on the antiangiogenic properties of flavonoids and chalcones and examines underlying mechanisms.
OCA17. List of maximum 5 most significant citations corresponding to the output	Costa R, Costa Lima SA, Gameiro P, Reis S. On the Development of a Cutaneous Flavonoid Delivery System: Advances and Limitations. Antioxidants (Basel). 2021 Aug 28;10(9):1376. doi: 10.3390/antiox10091376. (IF=6,312) Lowe HIC, Toyang NJ, Watson CT, Ayeah KN, Bryant J. HLBT-100: a highly potent anti-cancer flavanone from Tillandsia recurvata (L.) L. Cancer Cell Int. 2017 Mar 7;17:38. doi: 10.1186/s12935-017-0404-z. (IF 5,722) Wang L, Jin Y, Arnoldussen YJ, Jonson I, Qu S, Maelandsmo GM, Kristian A, Risberg B, Waehre H, Danielsen HE, Saatcioglu F. STAMP1 is both a proliferative and an antiapoptotic factor in prostate cancer. Cancer Res. 2010 Jul 15;70(14):5818-28. doi: 10.1158/0008-5472.CAN-09-4697. (IF=9,13) Rizeq B, Gupta I, Kheraldine H, Elkhalifa D, Al-Farsi HF, Moustafa AA, Khalil A. Novel Nitrogen-Based Chalcone Analogs Provoke Substantial Apoptosis in HER2-Positive Human Breast Cancer Cells via JNK and ERK1/ERK2 Signaling Pathways. Int J Mol Sci. 2021 Sep 6;22(17):9621. doi: 10.3390/ijms22179621. (IF=5,923) Ginwala R, Bhavsar R, Chigbu DI, Jain P, Khan ZK. Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin. Antioxidants (Basel). 2019 Feb 5;8(2):35. doi: 10.3390/antiox8020035. (IF=5,295)
OCA18. Characteristics of the output's impact on socio-economic practice	The current is study deals with anticancer/antiangiogenic effect of natural compounds that has a long tradition at our Department. Uncontrolled angiogenesis is a major contributor to a number of diseases. It is also considered a key step in tumour growth, invasion, and metastasis. Therefore, modulation of angiogenesis is considered as therapeutic strategies of great importance for human health. Numerous bioactive plant compounds have been recently tested for their antiangiogenic potential. This review article is focused on antiangiogenic effect of flavonoids and chalcones. Understanding the basic principles by which flavonoids and chalcones inhibits angiogenesis may lead to the development of new therapeutic strategies.
OCA19. Characteristics of the output and related activities' impact on the educational process	The field of angiogenesis inhibition is part of lectures for medical students. For PhD students, an important part of their study is the potential antitumor effect of natural substances. It can help them understand the antiangiogenic effect of newly synthesized substances.