| OCA16. Annotation of the output in English | The present study describes the ability of clove buds extract (CBE) to induce oxidative stress, DNA damage, and stress/survival/apoptotic pathways modulation human breast cancer MCF-7 cells. Obtained results demonstrated that CBE treatment induced intrinsic caspase-dependent cell death associated with increased oxidative stress mediated by oxygen and nitrogen radicals. In addition CBE mediated release of mitochondrial pro-apoptotic factors, signalling of oxidative stress-mediated DNA damage with modulation of cell antioxidant superoxide dismutase system, and modulation activity of the Akt, p38 MAPK, JNK and Erk 1/2 pathways. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | Niu D, Chen KL, Wang Y, Li XQ, Liu L, Ma X, Duan X. Hexestrol Deteriorates Oocyte Quality via Perturbation of Mitochondrial Dynamics and Function. Front Cell Dev Biol. 2021 Jul 6;9:708980. doi: 10.3389/fcell.2021.708980. (IF=6,684)
Jiang D, Xu J, Liu S, Nasser MI, Wei W, Mao T, Liu X, Zou X, Li J, Li X. Rosmanol induces breast cancer cells apoptosis by regulating PI3K/AKT and STAT3/JAK2 signaling pathways. Oncol Lett. 2021 Aug;22(2):631. doi: 10.3892/ol.2021.12892. (IF=2,967)
Lillo Urzúa P, Núñez Murillo O, Castro-Sepúlveda M, Torres-Quintana MA, Lladser Caldera Á, Quest AFG, Espinoza Robles C, Llanos Vidal P, Wehinger S. Loss of Caveolin-1 Is Associated with a Decrease in Beta Cell Death in Mice on a High Fat Diet. Int J Mol Sci. 2020 Jul 23;21(15):5225. doi: 10.3390/ijms21155225. (IF=5,923)
Sun X, Veeraraghavan VP, Surapaneni KM, Hussain S, Mathanmohun M, Alharbi SA, Aladresi AAM, Chinnathambi A. Eugenol-piperine loaded polyhydroxy butyrate/polyethylene glycol nanocomposite-induced apoptosis and cell death in nasopharyngeal cancer (C666-1) cells through the inhibition of the PI3K/AKT/mTOR signaling pathway. J Biochem Mol Toxicol. 2021 Apr;35(4):e22700. doi: 10.1002/jbt.22700. (IF=3,624)
Jingjing Zhang, Rong Jin, Yun Chen, Danjun Fang, Dechen Jiang. Enhanced electrochemiluminescence at single lithium iron phosphate nanoparticles for the local sensing of hydrogen peroxide efflux from single living cell under a low voltage. Sensors and Actuators B: Chemical, 2021, 329, 129208, doi.org/10.1016/j.snb.2020.129208. (IF=7,46) |
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| OCA18. Characteristics of the output's impact on socio-economic practice | In recent decades, several spices have been studied for their potential in the prevention and treatment of cancer. In this study, the ability of clove buds extract (CBE) to induce oxidative stress, DNA damage, and stress/survival/apoptotic pathways modulation were analysed in MCF-7 cells. Our data showed that CBE induced apoptosis in human breast cancer MCF-7 cells associated with ROS production, DNA damage and modulation of several signaling pathways. Furthermore, the modulation of Bcl-2 family proteins and leakage of pro-apoptotic proteins from mitochondria indicated the mitochondrial pathway of apoptosis. Together with our the previously published paper, presented results suggest that clove buds could be further developed as an anticancer agent. |
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