ADM - Vedecké práce v zahraničných časopisoch registrovaných v databázach Web of Science alebo SCOPUS IF=4.649, Q1, citované 8x

Basic data
OCA1. Surname awarded to the assessed person	Mojžiš
OCA2. Name awarded to the assessed person	Ján
OCA3. Degrees awarded to the assessed person	Prof. , DVM, DrSc.
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/14977
OCA5. Area of assessment	study programme pharmacy (joint study programme) · I. + II. degree
OCA6. Category of the research/artistic/other output
OCA7. Year of publication of the research/artistic/other output	2020
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	187999
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=29837531D12ABA4A47ACD7A980
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://pubmed.ncbi.nlm.nih.gov/32098428/
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADM - Vedecké práce v zahraničných časopisoch registrovaných v databázach Web of Science alebo SCOPUS IF=4.649, Q1, citované 8x
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.mdpi.com/2218-273X/10/2/345
OCA14. Characteristics of the author's contribution
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.
Other data
OCA16. Annotation of the output in English	The present study describes contribution of oxidative stress in antiproliferative activity of (2 E)-3-(acridin-9-yl)-1-(2,6-dimethoxyphenyl)prop-2-en-1-one (1C) in human colorectal HCT116 cells. The study demonstrates that chalcone 1C induced oxidative stress via increased reactive oxygen/nitrogen species (ROS/RNS) and superoxide production with a simultaneous weak adaptive activation of the cellular antioxidant defence mechanism. Co-treatment of cells with strong antioxidant, N-acetyl cysteine (NAC), significantly attenuated antiproliferative effect of 1C. Taken together, the role of ROS in the antiproliferative/pro-apoptotic effects of acridine chalcone 1C has been documented.
OCA17. List of maximum 5 most significant citations corresponding to the output	Rai V, Aggarwal SK, Verma SS, Awasthee N, Dhasmana A, Aggarwal S, Das SN, Nair MS, Yadav S, Gupta SC. Epoxyazadiradione exhibit activities in head and neck squamous cell carcinoma by targeting multiple pathways. Apoptosis. 2020 Oct;25(9-10):763-782. doi: 10.1007/s10495-020-01633-1. (IF=4.677) Kasetti AB, Singhvi I, Nagasuri R, Bhandare RR, Shaik AB. Thiazole-Chalcone Hybrids as Prospective Antitubercular and Antiproliferative Agents: Design, Synthesis, Biological, Molecular Docking Studies and In Silico ADME Evaluation. Molecules. 2021 May 11;26(10):2847. doi: 10.3390/molecules26102847. (IF=4,411) Abd Eldaim MA, Tousson E, El Sayed IET, Abd Elmaksoud AZ, Ahmed AAS. Ameliorative effects of 9-diaminoacridine derivative against Ehrlich ascites carcinoma-induced hepatorenal injury in mice. Environ Sci Pollut Res Int. 2021 May;28(17):21835-21850. doi: 10.1007/s11356-020-11857-y. (IF=4,223) Constantinescu, T.; Lungu, C.N. Anticancer Activity of Natural and Synthetic Chalcones. Int. J. Mol. Sci. 2021, 22, 11306. https://doi.org/10.3390/ijms222111306, (IF=5,923) Xue D, Zhou X, Qiu J. Cytotoxicity mechanisms of plumbagin in drug-resistant tongue squamous cell carcinoma. J Pharm Pharmacol. 2021 Mar 1;73(1):98-109. doi: 10.1093/jpp/rgaa027. (IF= 3,756)
OCA18. Characteristics of the output's impact on socio-economic practice	Colon cancer is the third most commonly diagnosed cancer and the second leading cause cancer mortality worldwide. Our previous results indicate that antiproliferative effect of compound chalcone 1C is associated with G2/M cell cycle arrest, induction of the mitochondrial pathway of apoptosis as well as modulation of selected signalling pathways. Some studies also indicate that the antiproliferative effect of chalcones may be associated with their pro-oxidant effect. In the present study, we demonstrated that chalcone 1C induced oxidative stress via increased reactive oxygen/nitrogen species and superoxide production. Furthermore, we also showed chalcone-induced mitochondrial dysfunction, DNA damage, apoptosis induction and activation of mitogen activated phosphokinase (MAPK) signalling pathway in 1C-treated cancer cells. Our data suggest that this chalcone may be useful as a promising anti-cancer agent for treating colon cancer.
OCA19. Characteristics of the output and related activities' impact on the educational process	For PhD students, an important part of their study is the potential antitumor effect of natural substances. It can help them understand the antiproliferative effect of chalcones in colorectal cancer.