ADC ANDREJČÁKOVÁ, Zuzana [25 %] - VLČKOVÁ, Radoslava [15 %] - SOPKOVÁ, Drahomíra [15 %] - KOZIOŁ, Katarzyna [5 %] - KOZIOROWSKI, Marek [5 %] - FABIÁN, Dušan [5 %] - ŠEFČÍKOVÁ, Zuzana [5 %] - HOLOVSKÁ, Katarína [10 %] - ALMÁŠIOVÁ, Viera [10 %] - SIROTKIN, Alexander V. [5 %]. Dietary flaxseed\'s protective effects on body tissues of mice after oral exposure to xylene. In Saudi journal of biological sciences. ISSN 1319-562X, 2021, vol. 28, no. 7, p. 3789-3798. (2020: 4.219 - IF, 4.432 - IF 5y, 53 - H-index, 0.710 - SJR, Q1 - SJR Best Q, Q2

ADC ANDREJČÁKOVÁ, Zuzana [25 %] - VLČKOVÁ, Radoslava [15 %] - SOPKOVÁ, Drahomíra [15 %] - KOZIOŁ, Katarzyna [5 %] - KOZIOROWSKI, Marek [5 %] - FABIÁN, Dušan [5 %] - ŠEFČÍKOVÁ, Zuzana [5 %] - HOLOVSKÁ, Katarína [10 %] - ALMÁŠIOVÁ, Viera [10 %] - SIROTKIN, Alexander V. [5 %]. Dietary flaxseed\'s protective effects on body tissues of mice after oral exposure to xylene. In Saudi journal of biological sciences. ISSN 1319-562X, 2021, vol. 28, no. 7, p. 3789-3798. (2020: 4.219 - IF, 4.432 - IF 5y, 53 - H-index, 0.710 - SJR, Q1 - SJR Best Q, Q2 - JCR Best Q).

Basic data
OCA1. Surname awarded to the assessed person	Vlčková
OCA2. Name awarded to the assessed person	Radoslava
OCA3. Degrees awarded to the assessed person	Assoc. prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6100
OCA5. Area of assessment	study programme cynology · I. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2021
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID: 250783
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=F6E878997955F571DE6C28CAE5
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADC ANDREJČÁKOVÁ, Zuzana [25 %] - VLČKOVÁ, Radoslava [15 %] - SOPKOVÁ, Drahomíra [15 %] - KOZIOŁ, Katarzyna [5 %] - KOZIOROWSKI, Marek [5 %] - FABIÁN, Dušan [5 %] - ŠEFČÍKOVÁ, Zuzana [5 %] - HOLOVSKÁ, Katarína [10 %] - ALMÁŠIOVÁ, Viera [10 %] - SIROTKIN, Alexander V. [5 %]. Dietary flaxseed\'s protective effects on body tissues of mice after oral exposure to xylene. In Saudi journal of biological sciences. ISSN 1319-562X, 2021, vol. 28, no. 7, p. 3789-3798. (2020: 4.219 - IF, 4.432 - IF 5y, 53 - H-index, 0.710 - SJR, Q1 - SJR Best Q, Q2 - JCR Best Q).
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://doi.org/10.1016/j.sjbs.2021.03.055
OCA14. Characteristics of the author's contribution	sampling and analysis, statistical data processing, article draft
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	Xylene is a common pollutant in the environment that enters the body of animals and humans in various ways, but most often through the respiratory tract and adversely affects their overall health. However, xylene effects after oral exposure have not been sufficiently studied. This study aimed to investigate the effects of xylene exposure on the mouse organism and to identify possible beneficial effects of flaxseed on such exposure. Eighty mice were divided into four groups: control group C (basal diet + no xylene exposure), group X (oral exposure by 400 mg/kg/day xylene), group F (10% flaxseed supplementation of basal diet), and group XF (10% dietary flaxseed + oral exposure by xylene). Experimental trial took 14 days. Clinical examination, spectroscopic analysis of tissue aminotransferases, total lactate dehydrogenase (TLDH), and acetylcholinesterase (AchE) activities, electrophoretic analysis of LDH isoenzymes, western blot and immunohistochemical analysis of apoptosis as well as routine histology of the kidneys and jejunum, and transmission electron microscopy of the liver were performed. Marked restlessness in group X and high weight losses in mice of all groups were recorded during the experiment. Xylene promoted apoptosis (caspase-3 expression) without causing marked structural changes in the liver and jejunum, although renal cortex structure was affected adversely. In the brain, liver, and kidney of mice, xylene increased levels of liver transaminases, LDH, and decreased AchE activities, reflecting cell membrane damage. Flaxseed feeding improved animal behaviour, leakage of enzymes and prevented selected tissue toxic damage induced by xylene by protecting cell membrane integrity and fluidity and by suppressing apoptosis. These results point at the protective effect of flaxseed consumption on mice.
Other data
OCA16. Annotation of the output in English	Xylene is a common pollutant in the environment that enters the body of animals and humans in various ways, but most often through the respiratory tract and adversely affects their overall health. However, xylene effects after oral exposure have not been sufficiently studied. This study aimed to investigate the effects of xylene exposure on the mouse organism and to identify possible beneficial effects of flaxseed on such exposure. Eighty mice were divided into four groups: control group C (basal diet + no xylene exposure), group X (oral exposure by 400 mg/kg/day xylene), group F (10% flaxseed supplementation of basal diet), and group XF (10% dietary flaxseed + oral exposure by xylene). Experimental trial took 14 days. Clinical examination, spectroscopic analysis of tissue aminotransferases, total lactate dehydrogenase (TLDH), and acetylcholinesterase (AchE) activities, electrophoretic analysis of LDH isoenzymes, western blot and immunohistochemical analysis of apoptosis as well as routine histology of the kidneys and jejunum, and transmission electron microscopy of the liver were performed. Marked restlessness in group X and high weight losses in mice of all groups were recorded during the experiment. Xylene promoted apoptosis (caspase-3 expression) without causing marked structural changes in the liver and jejunum, although renal cortex structure was affected adversely. In the brain, liver, and kidney of mice, xylene increased levels of liver transaminases, LDH, and decreased AchE activities, reflecting cell membrane damage. Flaxseed feeding improved animal behaviour, leakage of enzymes and prevented selected tissue toxic damage induced by xylene by protecting cell membrane integrity and fluidity and by suppressing apoptosis. These results point at the protective effect of flaxseed consumption on mice.
OCA17. List of maximum 5 most significant citations corresponding to the output	(Web of Science Core Collection:WOS:000919373200001) 1159139: Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers / Khan, Sosan Andleeb [Autor, 11.111%] ; Javeres, Mbah Ntepe Leonel [Autor, 11.111%] ; Shah, Syed Tahir Abbas [Autor, 11.111%] ; Bibi, Nazia [Autor, 11.111%] ; Muneer, Zahid [Autor, 11.111%] ; Hussain, Sabir [Autor, 11.111%] ; Nepovimova, Eugenie [Autor, 11.111%] ; Kuca, Kamil [Autor, 11.111%] ; Nurulain, Syed Muhammad [Autor, 11.112%]. – DOI 10.1016/j.envres.2022.115195. – WOS CC In: Environmental research [textový dokument (print)] [elektronický dokument] . – Amsterdam (Holandsko) : Elsevier. – ISSN 0013-9351. – ISSN (online) 1096-0953. – Roč. 220 (2023), s. [tlačená forma] [online] (Web of Science Core Collection:WOS:001083796900012) 1159138: Technical xylene induces maternal toxicity associated with organ inflammation during preimplantation stage in pregnant sprague-dawley rats / Suaidi, Noor Asyikin [Autor, 20%] ; Alshawsh, Mohammed Abdullah [Autor, 20%] ; Hoe, See-Ziau [Autor, 20%] ; Mokhtar, Mohd Helmy [Autor, 20%] ; Md. Zin, Siti Rosmani [Autor, 20%]. – DOI 10.4103/jasi.jasi_26_23. – WOS CC In: Journal of the Anatomical Society of India [textový dokument (print)] [elektronický dokument] . – Mumbai, Maharasashtra (India) : Wolters Kluwer Medknow publications. – ISSN 0003-2778. – ISSN (online) 2352-3050. – Roč. 72, č. 3 (2023), s. 252-261 [tlačená forma] [online
OCA18. Characteristics of the output's impact on socio-economic practice	The results achieved point to the positive effect of flaxseed intake on the body of mice, which are also applicable to other animal species and also to humans.
OCA19. Characteristics of the output and related activities' impact on the educational process	The outcomes of the output broaden students\' horizons in the area of the impact of environmental contaminants on animal health.