| Basic data |
|---|
| OCA1. Surname awarded to the assessed person | Petrovová |
|---|
| OCA2. Name awarded to the assessed person | Eva |
|---|
| OCA3. Degrees awarded to the assessed person | Prof. , DVM, PhD |
|---|
| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/6066 |
|---|
| OCA5. Area of assessment | study programme veterinary morphology and physiology · III. degree |
|---|
| OCA6. Category of the research/artistic/other output | scientific output |
|---|
| OCA7. Year of publication of the research/artistic/other output | 2021 |
|---|
| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | |
|---|
| OCA9. Hyperlink to the record in CRPA or CRAA | |
|---|
| Characteristics of the output that is not registered in CRPA or CRAA |
|---|
| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | |
|---|
| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | MEDVECKÝ, Ľubomír - GIRETOVÁ, Mária - ŠTULAJTEROVÁ, Radoslava - DANKO, Ján - VDOVIAKOVÁ, Katarína - KREŠÁKOVÁ, Lenka - ŽERT, Zdeněk - PETROVOVÁ, Eva - HOLOVSKÁ, Katarína - VARGA, Maroš - LUPTÁKOVÁ, Lenka - SOPČÁK, Tibor. Characterization of properties, in vitro and in vivo evaluation of calcium phosphate/amino acid cements for treatment of osteochondral defects. In: Materials. 2021. ISSN 1996-1944, Vol. 14, no. 2 (2021), art. no. 436, p. [1-27]
(2021: 3.748 - IF, 128 - H-index, 4.042 - IF 5y, 0.604 - SJR, Q2 - SJR Best Q, Q1 - JCR Best Q) |
|---|
| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
|---|
| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | |
|---|
| OCA14. Characteristics of the author's contribution | The publication is devoted to the use of calcium phosphate cements for the treatment of osteochondral defects. In vitro models, CAM model and pig model were used to confirm the efficacy of biomaterials. |
|---|
| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | Analysis clearly showed the excellent healing process of artificial osteochondral defects in pigs after treatment with CAL and CAK cements without any inflammation, as well as formation of subchondral bone and hyaline cartilage morphologically and structurally identical to the original tissues. |
|---|
| Other data |
|---|
| OCA16. Annotation of the output in English | The novel tetracalcium phosphate/monetite biocements with a 4 wt.% addition of amino acid mixture, characteristic of collagen (GLY, PRO, HYP and LYS or ARG), were characterized in terms of their material properties; furthermore, they were in vitro tested and successfully in vivo applied for treatment of osteochondral defects in large animal model (pigs). The measured material characteristics of biocements likely supported, positively, the proper formation of hyaline cartilage and subchondral bone defect healing. The RT-qPCR gene expression confirmed in vitro over expression of osteogenic genes in osteoblasts after 7 days of culture in CAL extracts, and no cytotoxicity of cement extract was identified. Results from macroscopic, histological and radiological analyses clearly showed the excellent healing process of artificial osteochondral defects in pigs after treatment with CAL and CAK cements without any inflammation, as well as formation of subchondral bone and hyaline cartilage that were morphologically and structurally identical with the original tissues. |
|---|
| OCA17. List of maximum 5 most significant citations corresponding to the output | |
|---|
| OCA18. Characteristics of the output's impact on socio-economic practice | The use of biomaterials based on calcium phosphate cements for the treatment of osteochondral defects in human and veterinary medicine. |
|---|
| OCA19. Characteristics of the output and related activities' impact on the educational process | |
|---|
