ADC ŠEVČÍK, Karol [35 %] - KARAFFOVÁ, Viera [35 %] - HLUCHÝ, Marián [10 %] - ŠEVČÍKOVÁ, Marieta [4 %] - ŠEVČÍKOVÁ, Zuzana [12 %] - LEDECKÝ, Valent [4 %]. Relationship of mRNA expression of selected genes in peripheral blood and synovial fluid in cranial cruciate ligament deficient stifles of dogs. In Animals. ISSN 2076-2615, 2022, vol. 12, no. 6, art. no. 754, p. [1-15]. (2021: 3.231 - IF, 3.312 - IF 5y, 43 - H-index, 0.610 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q). Dostupné na internete: https://www.mdpi.com/2076-2615/12/6/754

Basic data
OCA1. Surname awarded to the assessed person	Ševčíková
OCA2. Name awarded to the assessed person	Zuzana
OCA3. Degrees awarded to the assessed person	Prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6009
OCA5. Area of assessment	study programme veterinary surgery, orthopedics and radiology · III. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2022
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID473193
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=FEF7A5722FA4E7A310E54C9C50
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADC ŠEVČÍK, Karol [35 %] - KARAFFOVÁ, Viera [35 %] - HLUCHÝ, Marián [10 %] - ŠEVČÍKOVÁ, Marieta [4 %] - ŠEVČÍKOVÁ, Zuzana [12 %] - LEDECKÝ, Valent [4 %]. Relationship of mRNA expression of selected genes in peripheral blood and synovial fluid in cranial cruciate ligament deficient stifles of dogs. In Animals. ISSN 2076-2615, 2022, vol. 12, no. 6, art. no. 754, p. [1-15]. (2021: 3.231 - IF, 3.312 - IF 5y, 43 - H-index, 0.610 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q). Dostupné na internete: https://www.mdpi.com/2076-2615/12/6/754
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.mdpi.com/2076-2615/12/6/754
OCA14. Characteristics of the author's contribution	Contribution to the creation of the article hypothesis, its writing and statistical analysis
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	The cranial cruciate ligament rupture is characterized by chronic inflammation, osteoarthritis of the stifle joint, and extracellular matrix degeneration of the ligament itself in dogs. Early pre-clinical cranial cruciate ligament alteration cannot be detected by clinical examination or standard radiography. The results suggest a possible positive relationship between inflammatory markers of blood and synovial fluid in cranial cruciate ligament deficient stifles compared to the control. These findings may support both local and systemic inflammation process at the same time during osteoarthritis progression. Based on this, it would be interesting to investigate the predictive osteoarthritis pathway of inflammatory cytokines, matrix metalloproteinases, and their effect on the extracellular matrix components of the cranial cruciate ligament in future studies.
Other data
OCA16. Annotation of the output in English	The cranial cruciate ligament rupture (CrCLR) is characterized by chronic inflammation and osteoarthritis (OA) of the stifle joint and extracellular matrix (ECM) degeneration of the ligament itself in dogs. Generally, OA may arise from chronic low-grade systemic inflammation. We assessed the possible relationship of inflammatory markers in the peripheral blood (PB) and synovial fluid (SF) of affected stifle joints in comparison to a control. The results suggest a possible positive relationship between inflammatory markers of peripoheral blood (PB) and synovial fluid (S)F in CrCL deficient stifles compared to the control group. At the same time, it would be appropriate in the future to focus on monitoring other genes that may be involved in the inflammatory process using other methods such as RNA seq.
OCA17. List of maximum 5 most significant citations corresponding to the output	(SCOPUS:2-s2.0-85176783108) 1164144: Comparative digital study of two cranial rotation methods of the proximal fragment on the center of rotation of angulation-based leveling osteotomy planning with different tibial distal anatomical axes / Navarro, Barbara Georgina Cosgalla [Autor, 33.333%] ; Tudury, Eduardo Alberto [Autor, 33.334%] ; Flores, Gabriel Ignacio Ramirez [Autor, 33.333%]. – DOI 10.11606/issn.1678-4456.bjvras.2023.209837. – SCO In: Brazilian Journal of Veterinary Research and Animal Science. – ISSN 14139596. – ISSN (online) 16784456. – Roč. 60 (2023) Low Daniel et al: The association between gonadectomy and timing of gonadectomy, and the risk of canine cranial cruciate ligament disease: A systematic review and meta-analysis. Veterinary SurgeryVolume 54, Issue 2, Pages 254 - 267February 2025 Navaro Barbara G. C. et al. : Comparative digital study using four methods of measurements of the tibial distal anatomical axes for determining the anatomical-mechanical angle in dogs with cranial cruciate ligament rupture. American Journal of Veterinary ResearchOpen AccessVolume 85, Issue 7Jul 2024 Guénégo L. et al: Modified Cranial Closing Wedge Osteotomy (AMA-Based CCWO) to Treat Cranial Cruciate Ligament Deficient Stifle in 204 Dogs over 50 Kg: Magnitude of the Craniocaudal Angulation of the Proximal Tibia and Rate of Surgical Site Infection. Veterinary and Comparative Orthopaedics and TraumatologyOpen Access, 2024
OCA18. Characteristics of the output's impact on socio-economic practice	The exact etiopathogenesis of a cranial cruciate ligament (CrCL) rupture remains unknown despite extensive research. The degenerative changes occurring in the CrCL, it does not matter whether the source of degeneration is biological or biomechanical, are responsible for a progressive reduction of its elasticity and mechanical resistance, which make it more susceptible to even minimal trauma. This situation may promote degeneration and lead to partial or total rupture, with the coexistence of progressive osteoarthritis (OA) and inflammation of the stifle joint, which has a direct negative impact on the quality of life of the animal.
OCA19. Characteristics of the output and related activities' impact on the educational process	The musculosceletal system of animals, its physiological and pathological changes form an integral part of the veterinary surgeons education and the study of the rupture of the anterior cruciate ligament is a highly up-to-date and widespread pathological process with a direct negative impact on the animal ’ s quality of life.