ADD VLČKOVÁ, Radoslava [40 %] - ANDREJČÁKOVÁ, Zuzana [25 %] - SOPKOVÁ, Drahomíra [15 %] - KOZIOŁ, Katarzyna [5 %] - HERTELYOVÁ, Zdenka [5 %] - KOZIOROWSKA, Anna [5 %] - GANCARČÍKOVÁ, Soňa [5 %]. Effects of supplemental flaxseed on the ovarian and uterine functions of adult cycling mice. In General Physiology and Biophysics. ISSN 0231-5882, 2022, vol. 41, no. 3, p. 205-219. (2021: 1.957 - IF, 1.569 - IF 5y, 41 - H-index, 0.344 - SJR, Q3 - SJR Best Q, Q4

ADD VLČKOVÁ, Radoslava [40 %] - ANDREJČÁKOVÁ, Zuzana [25 %] - SOPKOVÁ, Drahomíra [15 %] - KOZIOŁ, Katarzyna [5 %] - HERTELYOVÁ, Zdenka [5 %] - KOZIOROWSKA, Anna [5 %] - GANCARČÍKOVÁ, Soňa [5 %]. Effects of supplemental flaxseed on the ovarian and uterine functions of adult cycling mice. In General Physiology and Biophysics. ISSN 0231-5882, 2022, vol. 41, no. 3, p. 205-219. (2021: 1.957 - IF, 1.569 - IF 5y, 41 - H-index, 0.344 - SJR, Q3 - SJR Best Q, Q4 - JCR Best Q)

Basic data
OCA1. Surname awarded to the assessed person	Sopková
OCA2. Name awarded to the assessed person	Drahomíra
OCA3. Degrees awarded to the assessed person	Assoc. prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6022
OCA5. Area of assessment	study programme veterinary morphology and physiology · III. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2022
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID = 48554
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioFormChildA14261&sid=5846AB7CDF2636F75FEC9A57F1&seo=CREP%C4%8C-detail-%C4%8Cl%C3%A1nok
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADD VLČKOVÁ, Radoslava [40 %] - ANDREJČÁKOVÁ, Zuzana [25 %] - SOPKOVÁ, Drahomíra [15 %] - KOZIOŁ, Katarzyna [5 %] - HERTELYOVÁ, Zdenka [5 %] - KOZIOROWSKA, Anna [5 %] - GANCARČÍKOVÁ, Soňa [5 %]. Effects of supplemental flaxseed on the ovarian and uterine functions of adult cycling mice. In General Physiology and Biophysics. ISSN 0231-5882, 2022, vol. 41, no. 3, p. 205-219. (2021: 1.957 - IF, 1.569 - IF 5y, 41 - H-index, 0.344 - SJR, Q3 - SJR Best Q, Q4 - JCR Best Q)
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	http://www.elis.sk/download_file.php?product_id=7689&session_id=bt9fdubnd3eavmu78hktkpqit1
OCA14. Characteristics of the author's contribution	sampling and analysis, statistical data processing, article draft
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	Dietary fatty acids (FA) have an impact on animal reproduction. The purpose of the study was to determine how supplemented flaxseed can modulate FA metabolism and how FAs can influence ovarian hormone release and uterine function through modulation of their specific receptors. Cycling mice were fed a basal diet (control) and a basal diet supplemented with 10% flaxseed for 6 weeks to examine its effects on ovarian and uterine structure and function and serum FA levels. In contrast to controls (30%), 100% of the flaxseed-fed mice showed estrus at the end of the supplementation period. Serum FAs were analyzed by gas chromatography. The ovaries and uterus underwent histological and immunohistochemical analyses. Ovarian fragments were cultured with or without follicle-stimulating hormone, and the culture media were analyzed for progesterone (P4) and estradiol-17beta (E2) by immunoassays. Flaxseed increased serum MK concentration, ovarian and primary follicle size, P4 and E2 release, endometrial and myometrial thickness, and altered estrogen and progesterone receptor expression in all uterine regions. Flaxseed may promote ovarian steroidogenesis and uterine activity in mice.
Other data
OCA16. Annotation of the output in English	Dietary fatty acids (FA) have an effect on animal reproduction. The purpose of the study was to find out how supplemental flaxseed can modulate the FA metabolism and how FA can influence the release of ovarian hormones and functions of the uteri through the modulation of their specific receptors. Cycling mice were fed a basal diet (control) and basal diet fortified with 10% flaxseed for 6 weeks to examine its influence on the structure and function of the ovaries and uteri, and serum levels of FA. Unlike controls (30%), 100% of mice fed flaxseed were exposed to oestrus at the end of the supplemental period. Serum FA were analysed using gas chromatography. The ovaries and uteri underwent histological and immunohistochemical analyses, respectively. The ovarian fragments were cultured with or without follicle-stimulating hormone, and culture media were analysed for progesterone (P4) and oestradiol-17β (E2) using immunoassays. Dietary flaxseed increased the serum FA concentration, sizes of the ovaries and primary follicles, the release of P4 and E2, the thickness of endometrium and myometrium, and altered the expression of oestrogen and progesterone receptors in all uterine compartments. Dietary flaxseed can promote ovarian steroidogenesis and uterine activity in the mouse.
OCA17. List of maximum 5 most significant citations corresponding to the output	(BIOSIS Citation Index:BCI:BCI202400043754) 1226160: A bibliometric analysis of global publications on flax (Linum usitatissimum L.) disease during 2001-2021 / Karimova, Sitora [Autor, 20%] ; Kholmuradov, Erkin [Autor, 20%] ; Juliev, Mukhiddin [Autor, 20%] ; Boytoraeva, Farangis [Autor, 20%] ; Nuraliyev, Hamro [Autor, 20%]. – DOI 10.37908/mkutbd.1234256 In: Mustafa Kemal Üniversitesi Tarım Bilimleri Dergisi [elektronický dokument] . – Turecko : Mustafa Kemal University. – ISSN 1300-9362. – ISSN (online) 2667-7733. – Roč. 28, č. 2 (2023), s. 413-426 (SCOPUS:2-s2.0-85160210779; Current Content Connect:CCC:000991476000002; Web of Science Core Collection:WOS:000936754300001) 1032802: Influence of Flaxseed (Linum usitatissimum) on Female Reproduction / Sirotkin, Alexander [Autor, 100%]. – [recenzované]. – DOI 10.1055/a-2013-2966. – WOS CC ; SCO ; CCC In: Planta Medica [textový dokument (print)] [elektronický dokument] : Journal of Medicinal Plant and Natural Product Research. – Stuttgart (Nemecko) : Thieme publishing group. – ISSN 0032-0943. – ISSN (online) 1439-0221. – 2023, s. [1-8] [tlačená forma] [online] (Web of Science Core Collection:WOS:001031138400001; SCOPUS:2-s2.0-85162003529; KIS:UVLF Košice_UvlkUnCat/0042410; Current Content Connect:CCC:001031138400001) 1060196: Can flaxseed, chia or puncture vine affect mare ovarian cell functions and prevent the toxic effect of the environmental contaminant toluene? / Sirotkin, Alexander [Autor, 20%] ; Tarko, Adam [Autor, 20%] ; Fabová, Zuzana [Autor, 20%] ; Valocký, Igor [Autor, 10%] ; Alwasel, Saleh H. [Autor, 10%] ; Kotwica, Jan [Autor, 10%] ; Harrath, Abdel Halim [Autor, 10%]. – [recenzované]. – DOI 10.1016/j.theriogenology.2023.06.018. – WOS CC ; SCO ; CCC In: Theriogenology [textový dokument (print)] [elektronický dokument] : an International Journal of Animal Reproduction. – Amsterdam (Holandsko) : Elsevier. – ISSN 0093-691X. – ISSN (online) 1879-3231. – Roč. 208 (2023), s. 178-184 [tlačená forma] [online] (SCOPUS:2-s2.0-85181123675) 1226159: Flaxseed (Linum usitatissimum); phytochemistry, pharmacological characteristics and functional food applications / Kauser, Samina [Autor, 8.333%] ; Hussain, Ashiq [Autor, 8.333%] ; Ashraf, Shahmir [Autor, 8.333%] ; Fatima, Ghulam [Autor, 8.333%] ; Ambreen [Autor, 8.334%] ; Javaria, Sadaf [Autor, 8.333%] ; Abideen, Zain Ul [Autor, 8.334%] ; Kabir, Khurram [Autor, 8.333%] ; Yaqub, Shazia [Autor, 8.334%] ; Akram, Saima [Autor, 8.333%] ; Shehzad, Anjum [Autor, 8.334%] ; Korma, Sameh A. [Autor, 8.333%]. – DOI 10.1016/j.focha.2023.100573. – SCO In: Food Chemistry Advances. – Oxford (Veľká Británia) : Elsevier. – ISSN (online) 2772-753X. – Roč. 4 (2024), 100573 [online] (Web of Science Core Collection:WOS:001295015600002; SCOPUS:2-s2.0-85201704725) 1226158: Flaxseed promotes productive performance through regulating gut microbiome in ducks / Yuan, Liyun [Autor, 12.5%] ; Zhang, Wenhao [Autor, 12.5%] ; Zhang, Lei [Autor, 12.5%] ; Zhang, Daitao [Autor, 12.5%] ; Zhang, Kai [Autor, 12.5%] ; Shi, Yu [Autor, 12.5%] ; Yuan, Zhihang [Autor, 12.5%] ; Zhao, Tao [Autor, 12.5%]. – DOI 10.1007/s11033-024-09858-y. – WOS CC ; SCO In: Molecular Biology Reports [textový dokument (print)] [elektronický dokument] . – Bazilej (Švajčiarsko) : Springer Nature. – ISSN 0301-4851. – ISSN (online) 1573-4978. – Roč. 51, č. 1 (2024), 923 [tlačená forma] [online]
OCA18. Characteristics of the output's impact on socio-economic practice	The results obtained point to the benefits and limitations of flaxseed intake in mice, which can be applied to other animal species and also to humans.
OCA19. Characteristics of the output and related activities' impact on the educational process	The results of the output point to their usefulness in influencing female reproduction.