ADC VLČKOVÁ, Radoslava [30 %] - SOPKOVÁ, Drahomíra [13 %] - ANDREJČÁKOVÁ, Zuzana [20 %] - LECOVÁ, Martina [5 %] - FABIAN, Dušan [5 %] - ŠEFČÍKOVÁ, Zuzana [5 %] - SEIDAVI, Alireza [2 %] - SIROTKIN, Alexander V. [20 %]. Dietary supplementation of Flaxseed (Linum usitatissimum L.) alters ovarian functions of xylene-exposed mice. In Life. ISSN 2075-1729, 2022, vol. 12, no. 8, art. no. 1152, p. [1-17]. (2021: 3.251 - IF, 40 - H-index, 0.588 - SJR, Q2 - SJR Best Q, Q2

ADC VLČKOVÁ, Radoslava [30 %] - SOPKOVÁ, Drahomíra [13 %] - ANDREJČÁKOVÁ, Zuzana [20 %] - LECOVÁ, Martina [5 %] - FABIAN, Dušan [5 %] - ŠEFČÍKOVÁ, Zuzana [5 %] - SEIDAVI, Alireza [2 %] - SIROTKIN, Alexander V. [20 %]. Dietary supplementation of Flaxseed (Linum usitatissimum L.) alters ovarian functions of xylene-exposed mice. In Life. ISSN 2075-1729, 2022, vol. 12, no. 8, art. no. 1152, p. [1-17]. (2021: 3.251 - IF, 40 - H-index, 0.588 - SJR, Q2 - SJR Best Q, Q2 - JCR Best Q).

Basic data
OCA1. Surname awarded to the assessed person	Sopková
OCA2. Name awarded to the assessed person	Drahomíra
OCA3. Degrees awarded to the assessed person	Assoc. prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6022
OCA5. Area of assessment	study programme veterinary morphology and physiology · III. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2022
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID: 497762
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=09E545CD95BD83831F91B74827
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADC VLČKOVÁ, Radoslava [30 %] - SOPKOVÁ, Drahomíra [13 %] - ANDREJČÁKOVÁ, Zuzana [20 %] - LECOVÁ, Martina [5 %] - FABIAN, Dušan [5 %] - ŠEFČÍKOVÁ, Zuzana [5 %] - SEIDAVI, Alireza [2 %] - SIROTKIN, Alexander V. [20 %]. Dietary supplementation of Flaxseed (Linum usitatissimum L.) alters ovarian functions of xylene-exposed mice. In Life. ISSN 2075-1729, 2022, vol. 12, no. 8, art. no. 1152, p. [1-17]. (2021: 3.251 - IF, 40 - H-index, 0.588 - SJR, Q2 - SJR Best Q, Q2 - JCR Best Q).
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://doi.org/10.3390/life12081152
OCA14. Characteristics of the author's contribution	sampling and analysis, statistical data processing, article draft
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	The aim of the performed study was to examine the ability of xylene, flaxseed, and their combinations to affect morphological and endocrine indexes of murine ovaries. The 72 indexes of secondary and tertiary follicular cells, oocytes, corpora lutea, and ovarian stroma have been quantified: diameter, markers of proliferation PCNA and apoptosis caspase 3, receptors to FSH, oxytocin, estrogen (alpha and beta), and progesterone. In addition, concentrations of the ovarian hormones progesterone, estradiol, and IGF‐I in the blood, as well as their production by isolated ovaries cultured with and without gonadotropins (FSH + LH mixture), were determined using histological, immunohistochemical, and immunoassay analyses. The character of xylene and flaxseed effects on ovarian functions in mice depended on the stage of ovarian folliculogenesis. It was shown that flaxseed could mitigate and prevent the major (63%) effects of xylene on the ovary. In addition, the ability of gonadotropins to affect ovarian hormone release and prevent its response to xylene has been shown. The effects of these additives could be mediated by changes in the release and reception of hormones. These observations suggest that flaxseed and possibly gonadotropins could be natural protectors of a female reproductive system against the adverse effects of xylene.
Other data
OCA16. Annotation of the output in English	The aim of the performed study was to examine the ability of xylene, flaxseed, and their combinations to affect morphological and endocrine indexes of murine ovaries. The 72 indexes of secondary and tertiary follicular cells, oocytes, corpora lutea, and ovarian stroma have been quantified: diameter, markers of proliferation PCNA and apoptosis caspase 3, receptors to FSH, oxytocin, estrogen (alpha and beta), and progesterone. In addition, concentrations of the ovarian hormones progesterone, estradiol, and IGF‐I in the blood, as well as their production by isolated ovaries cultured with and without gonadotropins (FSH + LH mixture), were determined using histological, immunohistochemical, and immunoassay analyses. The character of xylene and flaxseed effects on ovarian functions in mice depended on the stage of ovarian folliculogenesis. It was shown that flaxseed could mitigate and prevent the major (63%) effects of xylene on the ovary. In addition, the ability of gonadotropins to affect ovarian hormone release and prevent its response to xylene has been shown. The effects of these additives could be mediated by changes in the release and reception of hormones. These observations suggest that flaxseed and possibly gonadotropins could be natural protectors of a female reproductive system against the adverse effects of xylene.
OCA17. List of maximum 5 most significant citations corresponding to the output
OCA18. Characteristics of the output's impact on socio-economic practice	The results obtained indicate the impact of flaxseed feeding in mice on the reproductive process, as well as contamination with the environmental pollutant xylene, which can be applied to other animal species and also to humans.
OCA19. Characteristics of the output and related activities' impact on the educational process	The output\'s results expand students\' knowledge of how nutritional supplements and environmental pollutants influence dog reproduction.