ADC KARAFFOVÁ, Viera [40 %] - TELEKY, Jana [20 %] - PINTARIČ, Máša [3 %] - LANGERHOLC, Tomaž [3 %] - MUDROŇOVÁ, Dagmar [24 %] - HUDEC, Erik [5 %] - ŠEVČÍKOVÁ, Zuzana [5 %]. Application of Lactobacillus reuteri B1/1 (Limosilactobacillus reuteri) improves immunological profile of the non-carcinogenic porcine-derived enterocytes. In Life. ISSN 2075-1729, 2023, vol. 13, no. 5, art. no. 1090, p. [1-14]. (2022: 3.200 - IF, 3.200 - IF 5y, 46 - H-index, 0.634 - SJR, Q2 - SJR Best Q, Q2 - JCR Best Q). Dostupné na internete:

Basic data
OCA1. Surname awarded to the assessed person	Ševčíková
OCA2. Name awarded to the assessed person	Zuzana
OCA3. Degrees awarded to the assessed person	Prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6009
OCA5. Area of assessment	study programme veterinary surgery, orthopedics and radiology · III. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2023
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID 1053156
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=E84B3E3EDA810AC00D6D568372D1
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADC KARAFFOVÁ, Viera [40 %] - TELEKY, Jana [20 %] - PINTARIČ, Máša [3 %] - LANGERHOLC, Tomaž [3 %] - MUDROŇOVÁ, Dagmar [24 %] - HUDEC, Erik [5 %] - ŠEVČÍKOVÁ, Zuzana [5 %]. Application of Lactobacillus reuteri B1/1 (Limosilactobacillus reuteri) improves immunological profile of the non-carcinogenic porcine-derived enterocytes. In Life. ISSN 2075-1729, 2023, vol. 13, no. 5, art. no. 1090, p. [1-14]. (2022: 3.200 - IF, 3.200 - IF 5y, 46 - H-index, 0.634 - SJR, Q2 - SJR Best Q, Q2 - JCR Best Q). Dostupné na internete:
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.mdpi.com/2075-1729/13/5/1090
OCA14. Characteristics of the author's contribution	Management and implementation of trials and sampling collections
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	Výsledky práce ukázali, že inkubácia buniek CLAB probiotickými baktériami významne zvýšila metabolickú aktivitu buniek a následne výrazne zvýšila životaschopnosť buniek CLAB pri koncentrácii 109 CFU / ml po oboch expozičných časoch. Z údajov získaných v tejto štúdii vyplýva, že odpoveď CLAB buniek na expozíciu Lactobacillus reuteri B1 / 1 sa mení v závislosti od koncentrácie a trvania expozície.
Other data
OCA16. Annotation of the output in English	In our previous studies, Lactobacillus reuteri B1/1, which was renamed Limosilactobacillus reuteri (L. reuteri), was able to modulate the production of pro-inflammatory cytokines and other components of the innate immune response in vitro and in vivo. In this study, we evaluated the effect of Lactobacillus reuteri B1/1 in two concentrations (1 × 107 and 1 × 109 CFU) on the metabolic activity, adherence ability and relative gene expression of pro-inflammatory interleukins (IL-1β, IL-6, IL-8, IL-18), lumican and olfactomedin 4 produced by non-carcinogenic porcine-derived enterocytes (CLAB). CLAB cells were cultured in a 12-well cell culture plate at a concentration of 4 × 105 cells/well in DMEM medium in a controlled humidified atmosphere for 48 h. A 1 mL volume of each probiotic bacterial suspension was added to the CLAB cells. Plates were incubated for 2 h and 4 h. Our results revealed that L. reuteri B1/1 was able to adhere to CLAB cells in sufficient numbers in both concentrations. In particular, the concentration of 109 L. reuteri B1/1 allowed to modulate the gene expression of pro-inflammatory cytokines, as well as to increase the metabolic activity of the cells. In addition, administration of L. reuteri B1/1 in both concentrations significantly stimulated gene expression for both proteins in the CLAB cell line after 4 h of incubation.
OCA17. List of maximum 5 most significant citations corresponding to the output
OCA18. Characteristics of the output's impact on socio-economic practice	The extensive breeding of farm animals and the demands of consumers on the quality of animal products place emphasis on breeders and producers in the direction of improving animal health. In this context, in the last decade, the attention of the public and scientists has been focused on gaining knowledge about the use of probiotic bacteria and their products in animal health and diseases.
OCA19. Characteristics of the output and related activities' impact on the educational process	The physiology, pathology and immune system of the digestive tract, as well as its ability to adapt to various stimuli, constitute a complex and very extensive field of knowledge in veterinary medicine. The importance of a study on the impact of probiotics on GIT, overall performance and animal health is steadily increasing in relation to the provision of a one- health strategy.