Martina Bago Pilátová, Zuzana Solárová, Roman Mezencev, Peter Solár: Ceramides and their roles in programmed cell death. Adv Med Sci . 2023 Sep;68(2):417-425. doi: 10.1016/j.advms.2023.10.004. Epub 2023 Oct 20.
| Basic data | |
|---|---|
| OCA1. Surname awarded to the assessed person | Bago Pilátová |
| OCA2. Name awarded to the assessed person | Martina |
| OCA3. Degrees awarded to the assessed person | Assoc. prof. , DVM, PhD |
| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/15102 |
| OCA5. Area of assessment | study programme pharmacy (joint study programme) · I. + II. degree |
| OCA6. Category of the research/artistic/other output | scientific output |
| OCA7. Year of publication of the research/artistic/other output | 2023 |
| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | ID: 1105362 |
| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioForm&sid=81F62E49FBBAAFB06C80965B3179 |
| Characteristics of the output that is not registered in CRPA or CRAA | |
| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://pubmed.ncbi.nlm.nih.gov/37866204/ |
| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | Martina Bago Pilátová, Zuzana Solárová, Roman Mezencev, Peter Solár: Ceramides and their roles in programmed cell death. Adv Med Sci . 2023 Sep;68(2):417-425. doi: 10.1016/j.advms.2023.10.004. Epub 2023 Oct 20. |
| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | |
| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://www.sciencedirect.com/science/article/pii/S1896112623000445?via%3Dihub |
| OCA14. Characteristics of the author's contribution | |
| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | |
| Other data | |
| OCA16. Annotation of the output in English | Programmed cell death is essential for preserving the balance and functionality of multicellular organisms, and its disruption is linked to numerous pathological conditions. Among the key regulators of this process are ceramides—bioactive sphingolipids whose diverse roles depend on their cellular localization and interaction with specific targets. This review article explores the multifaceted functions of ceramides in various forms of programmed cell death, including apoptosis, anoikis, macroautophagy, mitophagy, and necroptosis. Special attention is given to the emerging role of dihydroceramides, previously considered inert intermediates, which are now recognized as active participants in cell signaling pathways. The article also discusses the influence of ceramide and dihydroceramide signaling on cancer progression, therapy resistance, and metastasis. Understanding these lipid mediators opens new perspectives for targeted therapeutic strategies in oncology and other diseases where cell death regulation is impaired. |
| OCA17. List of maximum 5 most significant citations corresponding to the output | TUFAIL, Muhammad - JIANG, Can Hua - LI, Ning. Altered metabolism in cancer: insights into energy pathways and therapeutic targets. In Molecular Cancer, 2024, roč. 23, č. 1, 02119; doi.org/10.1186/s12943-024-02119-3; Q1 IF: 27.7 TANG, Lingxuan - ZHANG, Wangzheqi - LIAO, Yan - WANG, Weijie - DENG, Xiaoming - WANG, Changli - SHI, Wenwen. Autophagy: a double-edged sword in ischemia-reperfusion injury. In Cellular & Molecular Biology Letters, 2025, roč. 30, č. 1.; doi: 10.1186/s11658-025-00713-x.; Q1 IF: 9.2 MONTEFUSCO, David - JAMIL, Maryam - CANALS, Daniel - SALIGRAMA, Siri - YUE, Yang - ALLEGOOD, Jeremy - COWART, L. Ashley. SPTLC3 regulates plasma membrane sphingolipid composition to facilitate hepatic gluconeogenesis. In Cell Reports, 2024, roč. 43, č. 12; doi: 10.1016/j.celrep.2024.115054.; Q1 IF: 7.5 GUERRE, Philippe - LASSALLETTE, Elodie - BEAUJARDIN-DAURIAN, Ugo - TRAVEL, Angelique. Fumonisins alone or mixed with other fusariotoxins increase the C22–24:C16 sphingolipid ratios in chicken livers, while deoxynivalenol and zearalenone have no effect. In Chemico-Biological Interactions, 2024, roč. 395, art. no. 111005; doi.org/10.1016/j.cbi.2024.111005.; Q1 IF: 5.779 ŁUKASZUK, Bartłomiej - SUPRUNIUK, Elżbieta - CHABOWSKI, Adrian - MIKŁOSZ, Agnieszka. Adipose tissue place of origin and obesity influence sphingolipid signaling pathway in the adipocytes differentiated from ADMSCs isolated from morbidly obese women. In Biochemical Pharmacology, 2024, roč. 223, art. no. 116158; doi: 10.1016/j.bcp.2024.116158., Q1 IF: 5.3 |
| OCA18. Characteristics of the output's impact on socio-economic practice | The acquired knowledge about the role of ceramides and dihydroceramides in the regulation of cell death can significantly contribute to the development of new, more targeted anticancer drugs, reduction of drug resistance, and improvement of treatment efficacy. The outcome has the potential to support the advancement of personalized medicine and innovations in the pharmaceutical and biotechnology industries. |
| OCA19. Characteristics of the output and related activities' impact on the educational process | The acquired knowledge about the role of ceramides and dihydroceramides in programmed cell death significantly enriches education in biomedical fields. It can be utilized in the development of lectures, seminars, and final theses, thereby promoting the integration of research with teaching and enhancing the quality of the educational process. |