Martina Pilatova , Lenka Ivanova, Peter Kutschy, Lenka Varinska, Lydia Saxunova, Maria Repovska, Marek Sarissky, Robert Seliga, Ladislav Mirossay, Jan Mojzis: In vitro toxicity of camalexin derivatives in human cancer and non-cancer cells. Toxicol In Vitro . 2013 Mar;27(2):939-44. doi: 10.1016/j.tiv.2013.01.006. Epub 2013 Jan 20.

Basic data
OCA1. Surname awarded to the assessed person	Bago Pilátová
OCA2. Name awarded to the assessed person	Martina
OCA3. Degrees awarded to the assessed person	Assoc. prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/15102
OCA5. Area of assessment	study programme pharmacy (joint study programme) · I. + II. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2013
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID: UPJŠ.Košice.000052429
OCA9. Hyperlink to the record in CRPA or CRAA	http://www.crepc.sk/portal?fn=*recview&uid=1069316&pageId=resultform&full=0
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://pubmed.ncbi.nlm.nih.gov/23339777/
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	Martina Pilatova , Lenka Ivanova, Peter Kutschy, Lenka Varinska, Lydia Saxunova, Maria Repovska, Marek Sarissky, Robert Seliga, Ladislav Mirossay, Jan Mojzis: In vitro toxicity of camalexin derivatives in human cancer and non-cancer cells. Toxicol In Vitro . 2013 Mar;27(2):939-44. doi: 10.1016/j.tiv.2013.01.006. Epub 2013 Jan 20.
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.sciencedirect.com/science/article/pii/S0887233313000076?via%3Dihub
OCA14. Characteristics of the author's contribution
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	n this study, the effects of benzocamalexin on tumor (IC50 = 23.3-30.1 μM) and non-tumor cells (IC50> 100.0 μM) were studied. Benzocamalexin caused blockade in the G2 phase of the cell cycle in tumor cells associated with decreased expression of α-tubulin, α1-tubulin, β5-tubulin, suggesting that the inhibitory effect of benzocamalexin is mediated by inhibition of microtubule formation. In addition, it reduced the expression of the microtubule-related protein required for microtubule assembly. These changes subsequently led to apoptosis accompanied by decreased expression of the anti-apoptotic genes Bcl-2 and Bcl-xL and overexpression of proapoptotic Bax and DNA fragmentation.
Other data
OCA16. Annotation of the output in English	Uncontrolled angiogenesis is a major contributor to a number of disease states. It is also considered a key step in tumour growth, invasion, and metastasis. Therefore, modulation of angiogenesis is considered as therapeutic strategies of great importance for human health. Numerous bioactive plant compounds are recently tested for their antiangiogenic potential. Among the most frequently studied are polyphenols present in fruits and vegetables. This review focuses on the antiangiogenic properties of flavonoids and chalcones and examines underlying mechanisms.
OCA17. List of maximum 5 most significant citations corresponding to the output	ALMASRY, M., JEMAÀ, M., MISCHITELLI, M., LANG, F., FAGGIO, C. Camalexin-Induced Cell Membrane Scrambling and Cell Shrinkage in Human Erythrocytes. In Cellular Physiology and Biochemistry, 2017, vol. 41, no. 2, s. 731-741. doi:10.1159/000458733. (IF=5,491) AHMED, S., KOVINICH, N. Regulation of phytoalexin biosynthesis for agriculture and human health. In Phytochemistry Reviews, 2021, roč. 20, č. 2, s. 483-505. doi:10.1007/s11101-020-09691-8. (IF 5,374) HONG, T. et al. Brassinin Inhibits Proliferation in Human Liver Cancer Cells via Mitochondrial Dysfunction. In Cells, 2021, roč. 10, č. 2, art. no. 332. doi:10.3390/cells10020332. (IF=4,326) HWANG, H.S. et al. Benzothiazole Synthesis: Mechanistic Investigation of an in Situ-Generated Photosensitizing Disulfide. In Journal of Organic Chemistry, 2020, roč. 85, č. 18, s. 11835-11843. doi:10.1021/acs.joc.0c01598. (IF=4,354) ZHU, S., WANG, Q., JIANG, J., LUO, Y., SUN, Z. A conjugate of methotrexate and an analog of luteinizing hormone releasing hormone shows increased efficacy against prostate cancer. In Scientific Reports, 2016, vol. 6, art. no. 33894. doi: 10.1038/srep33894. (IF=4,259)
OCA18. Characteristics of the output's impact on socio-economic practice	Many currently used drugs have been created by structural modification of natural substances, which play an important role in the treatment of many diseases, including cancer. Despite advances in the diagnosis and development of new treatments, cancer is one of the most common causes of death. Their current therapy is associated with a number of side effects, which is related to its non-selective action. For this reason, scientific teams are trying to find new compounds with lower toxicity and a better therapeutic response. This article discusses a possible mechanism of antiproliferative action of camalexin.
OCA19. Characteristics of the output and related activities' impact on the educational process	General pharmacology also includes the development of new drugs, including preclinical drugs. This issue is part of the pharmacology syllabus. The work enables medical and doctoral students to gain at least a simplified view of the complexity of the process of finding new compounds with potential antiproliferative effect in the basic preclinical screening phase in in vitro experiments at the cellular and subcellular level.