| Basic data |
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| OCA1. Surname awarded to the assessed person | Mojžiš |
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| OCA2. Name awarded to the assessed person | Ján |
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| OCA3. Degrees awarded to the assessed person | Prof. , DVM, DrSc. |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/14977 |
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| OCA5. Area of assessment | study programme pharmacy (joint study programme) · I. + II. degree |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2024 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | |
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| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioForm&sid=348A98D36B4D29CBEBAF2EF44F7A |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://pubmed.ncbi.nlm.nih.gov/39062784/ |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | Šimon Salanci, Mária Vilková, Lola Martinez, Ladislav Mirossay Radka Michalková, Ján Mojžiš: The Induction of G2/M Phase Cell Cycle Arrest and Apoptosis by the Chalcone Derivative 1C in Sensitive and Resistant Ovarian Cancer Cells Is Associated with ROS Generation. Int J Mol Sci
. 2024 Jul 9;25(14):7541. doi: 10.3390/ijms25147541.
V3 - Vedecký výstup publikačnej činnosti z časopisu IF=5,6; Q1 (cit. 3) |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://www.mdpi.com/1422-0067/25/14/7541 |
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| OCA14. Characteristics of the author's contribution | |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | |
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| Other data |
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| OCA16. Annotation of the output in English | This study explores the antiproliferative potential of the chalcone derivative 1C in both cisplatin-sensitive (A2780) and cisplatin-resistant (A2780cis) ovarian cancer cell lines. Compound 1C was shown to reduce cell viability, induce G2/M cell cycle arrest, and promote apoptosis through mechanisms involving the generation of reactive oxygen species (ROS). It also modulated key molecular targets, including p21, PCNA, Rb, Bad, PARP, and influenced Akt, Erk1/2, and NF-κB signaling pathways. Notably, 1C altered Nrf2 expression in a time- and cell type-dependent manner, with opposing trends in sensitive and resistant cells. The antioxidant N-acetylcysteine (NAC) mitigated most effects of 1C, highlighting ROS as a central mediator. These findings suggest that ROS-mediated modulation of Nrf2 and associated signaling pathways contributes to the antiproliferative action of chalcone 1C and underscore its potential in overcoming drug resistance in ovarian cancer. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | AL KHZEM, Abdulaziz H. - GOMAA, Mohamed S. - ALTURKI, Mansour S. - TAWFEEQ, Nada - SARAFROZ, Mohammad - ALONAIZI, Shareefa M. - AL FARAN, Alhassan - ALRUMAIHI, Laela Ahmed - ALANSARI, Fatimah Ahmed - ALGHAMDI, Abdullah Abbas. Drug Repurposing for Cancer Treatment: A Comprehensive Review. In International journal of molecular sciences, 2024, roč. 25, č. 22.
FAHIM, Christeen - ABDOLLAH, Maha R.A. - LABIB, Rola M. - IBRAHIM, Nehal - SWILAM, Noha. Phytochemical Analysis and In Vivo Anticancer Effect of Becium grandiflorum: Isolation and Characterization of a Promising Cytotoxic Diterpene. In Nutrients, 2025, roč. 17, č. 7, 17071164
WIRASWATI, Hesti Lina - MA’RUF, Ilma Fauziah - HIDAYATI, Nur Akmalia - RAMADHANTI, Julia - CALINA, Daniela - SHARIFI-RAD, Javad. Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects. In Discover Oncology, 2025, roč. 16, č. 1. |
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| OCA18. Characteristics of the output's impact on socio-economic practice | The study suggests that chalcone 1C could help overcome drug resistance in ovarian cancer, potentially improving treatment outcomes and reducing healthcare costs. Its natural origin and effectiveness support the development of affordable therapies, making advanced cancer care more accessible and economically sustainable. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | The study enhances the integration of research into education in oncology and pharmacology. Students gain hands-on experience with experimental methods, drug mechanisms, and cancer resistance models, thereby improving the quality of education and fostering scientific thinking. |
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