| Basic data |
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| OCA1. Surname awarded to the assessed person | Novotný |
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| OCA2. Name awarded to the assessed person | Jaroslav |
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| OCA3. Degrees awarded to the assessed person | Assoc. prof. , DVM, PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/6072 |
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| OCA5. Area of assessment | study programme general veterinary medicine · I. + II. degree |
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| OCA6. Category of the research/artistic/other output | |
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| OCA7. Year of publication of the research/artistic/other output | 2024 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | 1240596 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioForm&sid=111DEF23A8694C1DD0D92E2AF267 |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://link.springer.com/article/10.1007/s11259-024-10445-6 |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | Exopolysaccharides from Limosilactobacillus reuteri: their influence on in vitro activation of porcine monocyte-derived dendritic cells - brief report / Kiššová, Zuzana [Autor, 25%] ; Schusterová, Petra [Autor, 40%] ; Mudroňová, Dagmar [Autor, 20%] ; Novotný, Jaroslav [Autor, 5%] ; Tkáčiková, Ľudmila [Autor, 10%]. – [recenzované]. – DOI 10.1007/s11259-024-10445-6. – CCC ; WOS CC ; SCO.
In: Veterinary research communications [textový dokument (print)] [elektronický dokument] . – Amsterdam (Holandsko) : Springer Nature. – ISSN 0165-7380. – ISSN (online) 1573-7446. – Roč. 48, č. 5 (2024), s. 3315-3321 [tlačená forma] |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://link.springer.com/article/10.1007/s11259-024-10445-6 |
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| OCA14. Characteristics of the author's contribution | Writing – review & editing. |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | The aim of this study was to evaluate the immunomodulatory potential of two α-D-glucans from Limosilactobacillus reuteri L26 Biocenol™ (EPS-L26) and L. reuteri DSM17938 (EPS-DSM17938), with respect to their influence on in vitro activation of porcine dendritic cells (DCs). We used immature DCs differentiated from porcine blood monocytes under in vitro conditions. Based on the surface expression of MHC II and costimulatory CD80/86 molecules, we showed that both used EPSs favour the maturation of monocyte-derived DCs (MoDCs) similarly to the commonly used stimulant tumour necrosis factor α (TNF-α). In contrast to TNF-α stimulation, MoDCs treated with both used EPSs significantly up-regulated the mRNA levels not only for interleukin (IL)-10 (P |
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| Other data |
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| OCA16. Annotation of the output in English | |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | https://www.researchgate.net/publication/394008991_A_promising_Staphylococcus_aureus_vaccine_adjuvant_candidate_to_overcome_Staphylococcal_infection_based_on_innate_immunity
https://www.researchgate.net/publication/384067752_Advances_in_Microbial_Exopolysaccharides_Present_and_Future_Applications |
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| OCA18. Characteristics of the output's impact on socio-economic practice | Support for veterinary immunology and health management of pigs:
The study of the immunomodulatory effects of α-D-glucans on porcine dendritic cells provides new insights into stimulating immune responses, which can lead to more effective disease prevention in herds and overall improvement of animal health.
Potential for the development of new immunomodulatory supplements and therapeutics:
Identifying the effects of EPS-L26 and EPS-DSM17938 on cytokine production and dendritic cell maturation can serve as a basis for developing functional feed additives or biological products to support pig immunity in commercial farming.
Economic benefit for pig farming:
Improved immunity and health of pigs lead to reduced disease incidence, lower mortality, and decreased need for treatment, directly impacting farm efficiency and the economic performance of large-scale pig production. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | The publication is suitable study literature for students of the general veterinary medicine and food hygiene study program. |
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