V3 / ADC TAKÁČ, Peter [20 %] - MICHALKOVÁ, Radka [16 %] - ČIŽMÁRIKOVÁ, Martina [16 %] - BEDLOVIČOVÁ, Zdenka [16 %] - BALÁŽOVÁ, Ľudmila [16 %] - TAKÁČOVÁ, Gabriela [16 %]. The role of silver nanoparticles in the diagnosis and treatment of cancer: Are there any perspectives for the future? In Life. ISSN 2075-1729, 2023, vol. 13, no. 2, art. no. 466, p. [1-44]. (2022: 3.2 - IF, 3.2 - IF 5y, 46 - H-index, 0.634 - SJR, Q2 - SJR Best Q, Q2 - JCR Best Q). Dostupné na internete: .

Basic data
OCA1. Surname awarded to the assessed person	Takáč
OCA2. Name awarded to the assessed person	Peter
OCA3. Degrees awarded to the assessed person	Assoc. prof. , Pharm.D., PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/27235
OCA5. Area of assessment	study programme pharmacy (joint study programme) · I. + II. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2023
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID: 1041534
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=74DC020A23E61A164776ED04B91F
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	V3 / ADC TAKÁČ, Peter [20 %] - MICHALKOVÁ, Radka [16 %] - ČIŽMÁRIKOVÁ, Martina [16 %] - BEDLOVIČOVÁ, Zdenka [16 %] - BALÁŽOVÁ, Ľudmila [16 %] - TAKÁČOVÁ, Gabriela [16 %]. The role of silver nanoparticles in the diagnosis and treatment of cancer: Are there any perspectives for the future? In Life. ISSN 2075-1729, 2023, vol. 13, no. 2, art. no. 466, p. [1-44]. (2022: 3.2 - IF, 3.2 - IF 5y, 46 - H-index, 0.634 - SJR, Q2 - SJR Best Q, Q2 - JCR Best Q). Dostupné na internete: .
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)
OCA14. Characteristics of the author's contribution
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.
Other data
OCA16. Annotation of the output in English	Cancer is a fatal disease with a complex pathophysiology. Lack of specificity and cytotoxicity, as well as the multidrug resistance of traditional cancer chemotherapy, are the most common limitations that often cause treatment failure. Thus, in recent years, significant efforts have concentrated on the development of a modernistic field called nano-oncology, which provides the possibility of using nanoparticles (NPs) with the aim to detect, target, and treat cancer diseases. In comparison with conventional anticancer strategies, NPs provide a targeted approach, preventing undesirable side effects. What is more, nanoparticle-based drug delivery systems have shown good pharmacokinetics and precise targeting, as well as reduced multidrug resistance. It has been documented that, in cancer cells, NPs promote reactive oxygen species (ROS) production, induce cell cycle arrest and apoptosis, activate ER (endoplasmic reticulum) stress, modulate various signaling pathways, etc. Furthermore, their ability to inhibit tumor growth in vivo has also been documented. In this paper, we have reviewed the role of silver NPs (AgNPs) in cancer nanomedicine, discussing numerous mechanisms by which they render anticancer properties under both in vitro and in vivo conditions, as well as their potential in the diagnosis of cancer.
OCA17. List of maximum 5 most significant citations corresponding to the output	[1]/[1] GOU, Jin - LU, Chen - LIU, Tianyu - JI, Pengchen - YUAN, Jiaying - YU, Chunzhao. Metal-based nanomedicine systems for the diagnosis and treatment of colorectal cancer: Current advances and future perspectives. In Materials Today Chemistry, 2025-04-01, 45, pp. Dostupné na: https://doi.org/10.1016/j.mtchem.2025.102702., Registrované v: SCOPUS [1]/[1] MOHAMED, Farzana - CHENIA, Hafizah Yousuf. Antimicrobial, Quorum Sensing Inhibition, and Anti-Cancer Activities of Silver Nanoparticles Synthesized from Kenyan Bacterial Endophytes of Teclea nobilis. In International Journal of Molecular Sciences, 2025-04-01, 26, 7, pp. ISSN 16616596. Dostupné na: https://doi.org/10.3390/ijms26073306., Registrované v: SCOPUS [1]/[1] PLOTNIKOV, Evgenii V. - DROZD, Anastasia G. - ARTAMONOV, Anton A. - LARKINA, Maria S. - BELOUSOV, Mikhail V. - LOMOV, Ivan V. - GARIBO, D. - PESTRYAKOV, Alexey N. - BOGDANCHIKOVA, Nina. Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study. In Nanomedicine: Nanotechnology, Biology, and Medicine, 2025-04-01, 65, pp. ISSN 15499634. Dostupné na: https://doi.org/10.1016/j.nano.2025.102813., Registrované v: WOS, SCOPUS [1]/[1] SOROUSHNASAB, Hasti - GHARBAVI, Mahmoud - ESKANDARI, Mehdi - REZAEEJAM, Hamed - GHORBANI, Roghayeh - JOHARI, Behrooz. Methotrexate-conjugated silver nanoparticles enhance chemoradiotherapy effects on U87 human glioblastoma multiforme cells: As a radiosensitizer agent to improve X-irradiation efficacy. In Journal of Drug Delivery Science and Technology, 2025-05-01, 107, pp. ISSN 17732247. Dostupné na: https://doi.org/10.1016/j.jddst.2025.106791., Registrované v: SCOPUS [1]/[1] AHAMAD, Irshad - NADEEM, Masood - RIZVI, M. Moshahid Alam - FATMA, Tasneem. Bio-fabricated silver nanoparticles: therapeutic evaluation as a potential nanodrug against cervical and liver cancer cells. In Discover Nano, 2025-12-01, 20, 1, pp. Dostupné na: https://doi.org/10.1186/s11671-025-04212-y., Registrované v: WOS, SCOPUS
OCA18. Characteristics of the output's impact on socio-economic practice	The output provides an important contribution to socio-economic practice by summarizing current knowledge on the use of silver nanoparticles (AgNPs) in cancer diagnosis and treatment. It highlights several mechanisms through which AgNPs demonstrate anticancer effects both in vitro and in vivo, opening new possibilities for personalized medicine. The article also suggests the potential of AgNPs for earlier cancer detection, which could lead to more effective therapies and reduced healthcare costs. These insights may influence the direction of research, investments in nanomedicine, and the development of new biotechnological solutions, thereby contributing to innovations with both social and economic impact.
OCA19. Characteristics of the output and related activities' impact on the educational process	The output and related activities significantly enrich the educational process, particularly in the fields of biomedical and pharmaceutical research. The article provides students with up-to-date and comprehensive information on the application of silver nanoparticles (AgNPs) in oncology, thereby fostering critical thinking and linking theoretical knowledge with practice. The topic of nanomedicine motivates students to adopt an interdisciplinary approach, combining chemistry, biology, medicine, and materials science. It also creates opportunities for student involvement in research projects and the development of practical skills. Furthermore, discussions on the ethical and regulatory aspects of using nanotechnologies in healthcare enhance their ability to reflect on the societal context of science. This output thus contributes meaningfully to the modernization of education and supports research-oriented and innovation-driven learning.