ADC KUDLIČKOVÁ, Zuzana [40 %] - TAKÁČ, Peter [20 %] - SABOLOVÁ, Danica [20 %] - VILKOVÁ, Mária [5 %] - BALÁŽ, Matej [5 %] - BÉRES, Tibor [5 %] - MOJŽIŠ, Ján [5 %]. Novel 1-methoxyindole- and 2-alkoxyindole-based chalcones: design, synthesis, characterization, antiproliferative activity and DNA, BSA binding interactions. In Medicinal Chemistry Research. ISSN 1054-2523, 2021, vol. 30, no. 4, p. 897-912. (2021: 2.351 - IF, 2.261 - IF 5y, 50 - H-index, 0.357 - SJR, Q2 - SJR Best Q, Q4 - JCR Best Q). (2021 - Current Contents). Dostupné na internete: .

Basic data
OCA1. Surname awarded to the assessed person	Takáč
OCA2. Name awarded to the assessed person	Peter
OCA3. Degrees awarded to the assessed person	Assoc. prof. , Pharm.D., PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/27235
OCA5. Area of assessment	study programme pharmacy · I. + II. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2021
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID: 246244
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=31C8E708FF3B216F2A084DC45D
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADC KUDLIČKOVÁ, Zuzana [40 %] - TAKÁČ, Peter [20 %] - SABOLOVÁ, Danica [20 %] - VILKOVÁ, Mária [5 %] - BALÁŽ, Matej [5 %] - BÉRES, Tibor [5 %] - MOJŽIŠ, Ján [5 %]. Novel 1-methoxyindole- and 2-alkoxyindole-based chalcones: design, synthesis, characterization, antiproliferative activity and DNA, BSA binding interactions. In Medicinal Chemistry Research. ISSN 1054-2523, 2021, vol. 30, no. 4, p. 897-912. (2021: 2.351 - IF, 2.261 - IF 5y, 50 - H-index, 0.357 - SJR, Q2 - SJR Best Q, Q4 - JCR Best Q). (2021 - Current Contents). Dostupné na internete: .
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)
OCA14. Characteristics of the author's contribution
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.
Other data
OCA16. Annotation of the output in English	Indole-based chalcones have been identified as interesting compounds with anticancer properties. In the present study, we report the synthesis and evaluation of new 1-methoxyindole and 2-alkoxyindole chalcone hybrids as antiproliferative agents active against colorectal carcinoma cell line. Among the 19 investigated molecules, four inhibit the proliferation of colorectal cancer cells HCT-116 with IC50 values
OCA17. List of maximum 5 most significant citations corresponding to the output	[1] WANG, Jie - ANSARI, Mohammad Fawad - ZHOU, Cheng-He. Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. In JOURNAL OF MEDICINAL CHEMISTRY. ISSN 0022-2623, 2021, vol. 64, no. 11, pp. 7630-7645. Dostupné na: https://doi.org/10.1021/acs.jmedchem.1c00334., Registrované v: WoS [1]/[1] HARMOŠOVÁ, Michaela - KELLO, Martin - GOGA, Michal - FRENÁK, Richard - TKÁČIKOVÁ, Ľudmila - VILKOVÁ, Mária - SABOLOVÁ, Danica - SOVOVÁ, Simona - SAMOĽOVÁ, Erika - POTOČŇÁK, Ivan. Low-dimensional compounds containing bioactive ligands. Part XXI: Crystal structures, cytotoxic, antimicrobial activities and BSA binding of zinc complexes with 5-chloro-7-nitro-8-hydroxyquinoline. In Polyhedron, 2023-05-01, 235, pp. ISSN 02775387. Dostupné na: https://doi.org/10.1016/j.poly.2023.116347., Registrované v: SCOPUS [1]/[1] LEITE, Fernando Ferreira - DE SOUSA, Natália Ferreira - DE OLIVEIRA, Bruno Hanrry Melo - DUARTE, Gabrielly Diniz - FERREIRA, Maria Denise Leite - SCOTTI, Marcus Tullius - FILHO, José Maria Barbosa - RODRIGUES, Luís Cezar - DE MOURA, Ricardo Olímpio - MENDONÇA-JUNIOR, Francisco Jaime Bezerra - SCOTTI, Luciana. Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies. In Molecules, 2023-05-01, 28, 10, pp. Dostupné na: https://doi.org/10.3390/molecules28104009., Registrované v: SCOPUS [1]/[1] WANG, Huan - ZHU, Juanying - ZHANG, Qianru - TANG, Jie - HUANG, Xufeng. Current scenario of chalcone hybrids with antibreast cancer therapeutic applications. In Archiv der Pharmazie, 2024-05-01, 357, 5, pp. ISSN 03656233. Dostupné na: https://doi.org/10.1002/ardp.202300640., Registrované v: SCOPUS
OCA18. Characteristics of the output's impact on socio-economic practice	The output brings a significant contribution to socio-economic practice through the discovery of new indole-based chalcone hybrids with anticancer effects against colorectal carcinoma. Four of these compounds demonstrated effective inhibition of tumor cell growth at low concentrations while exhibiting low toxicity to healthy cells, indicating a favorable safety profile. Their interaction with DNA and serum proteins reveals mechanisms of action that could serve as a basis for developing new, more targeted and effective drugs. This research has the potential to improve colorectal cancer treatment, reduce side effects, and lower healthcare costs. Additionally, it supports innovation in the pharmaceutical industry and may stimulate economic growth through the development of new biotechnological products with significant societal impact.
OCA19. Characteristics of the output and related activities' impact on the educational process	The output and related activities significantly enrich the educational process in pharmacy, molecular biology, and biotechnology. Students gain knowledge about the synthesis and effects of new indole-based chalcone hybrids, including their mechanisms of interaction with DNA and proteins, deepening their understanding of molecular processes in cancer treatment. This research fosters the development of critical thinking, practical laboratory skills, and an interdisciplinary approach combining chemistry, biology, and medicine. Involvement in similar projects motivates students toward scientific work and innovation. It also prepares them for current challenges in biomedical research, contributing to the formation of qualified professionals ready to apply modern knowledge in practice.