Solárová Zuzana, Kello Martin, Hamuľaková Slávka, Mirossay Ladislav, Solár, Peter: Anti-cancer effect of tacrine-coumarin derivatives on diverse human and mouse cancer cell lines. Acta Chimica Slovenica ADC - Vedecké práce v zahraničných karentovaných časopisoch IF 1,076, Q1-SJR, citované 3x

Basic data
OCA1. Surname awarded to the assessed person	Solárová
OCA2. Name awarded to the assessed person	Zuzana
OCA3. Degrees awarded to the assessed person	Assoc. prof. , M.D., PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/15120?mode=full
OCA5. Area of assessment	study programme pharmacy (joint study programme) · I. + II. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2018
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioFormChildCL0GU&sid=D79AF36B738BACD5C0416029
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	Solárová Zuzana, Kello Martin, Hamuľaková Slávka, Mirossay Ladislav, Solár, Peter: Anti-cancer effect of tacrine-coumarin derivatives on diverse human and mouse cancer cell lines. Acta Chimica Slovenica ADC - Vedecké práce v zahraničných karentovaných časopisoch IF 1,076, Q1-SJR, citované 3x
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)
OCA14. Characteristics of the author's contribution	SOLÁROVÁ, Zuzana (70%) - KELLO, Martin (10%) - VARINSKÁ, Lenka (5%) - BUDOVSKÁ,Mariana (5%) - SOLÁR, Peter (10%)
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	Acridine derivatives were first used as antibacterial and antiparasitic agents, later as antimalarials and anti-HIV drugs, and are currently being investigated as potential anticancer agents due to their high cytotoxic activity. Because of their serious side effects, new synthetic derivatives based on modified naturally occurring substances, such as acridone derivatives, which also show potential antitumor activity, have been developed and tested. Most of them are DNA-damaging substances, causing relatively strong and selective destruction of tumor cells. We tested the in vitro antiproliferative effects of newly synthesized tetrahydroacridine derivatives, specifically tacrine-coumarin hybrid molecules, on various human and mouse tumor cell lines. Our results showed that tacrine-coumarin hybrids with seven, eight and nine methylene groups in the linker chain reduced the proliferation of tumor cells. The hybrid with nine methylene groups had the most pronounced antitumor effect.
Other data
OCA16. Annotation of the output in English	Acridine derivatives were first used as antibacterial and antiparasitic agents, later as antimalarial and anti-HIV drugs, and now as potentially anti-cancer agents due to their high cytotoxic activity. Due to their serious adverse effects, new synthetic derivatives were introduced and tested based on modified naturally occurring substances, such as acridone derivatives, which also exhibit potential anti-tumor activity. Most of them are DNA-damaging substances, causing relatively strong and selective destruction of tumor cells. We have tested in vitro anti-proliferative effects of newly-synthesized tetrahydroacrid derivatives, namely tacrine-coumarin hybrid molecules, on various human and mouse cancer cell lines. Our results showed that tacrine-coumarin hybrids with seven, eight, and nine methylene groups in spacer reduce proliferation of cancer cells. A hybrid with nine methylene groups had the most significant anti-cancer effect.
OCA17. List of maximum 5 most significant citations corresponding to the output	RICHBART, Stephen D. - MERRITT, Justin C. - NOLAN, Nicholas A. - DASGUPTA, Piyali. Acetylcholinesterase and human cancers. In Advances in Cancer Research. 2021, doi: 10.1016/bs.acr.2021.05.001. (IF=6,242) YERER, Mukerrem Betul - DAYAN, Serkan - IHSAN HAN, M. - SHARMA, Ajay - TULI, Hardeep Singh - SAK, Katrin. Nanoformulations of coumarins and the hybrid molecules of coumarins with potential anticancer effects. In Anti-cancer agents in medicinal chemistry, 2020, doi: 10.2174/1871520620666200310094646. (IF 2,505) ZHANG, L., XU, Z. Coumarin-containing hybrids and their anticancer activities. In European Journal of Medicinal Chemistry, 2019, vol. 181, art. no. 111587, doi: 10.1016/j.ejmech.2019.111587. (IF=5,572)
OCA18. Characteristics of the output's impact on socio-economic practice	The work is focused towards anticancer effects of some new hybrid molecules. We have been dealing with this topic at our institute for a long time. This article focuses on tacrine-coumarin hybrids, which appear to be new promising antitumor agents.
OCA19. Characteristics of the output and related activities' impact on the educational process	The anticancer drugs are part of lectures for medical students. For PhD students, the potential antitumor effect of natural substances is an important part of their studies. This work can help them understand the new targets for many of anticancer drugs.