Papadakos Martina, Mučaji Pavel, Špaglová Miroslava, Čuchorová Mária, Macho Oliver: Chitosan and Sodium Alginate Implementation as Pharmaceutical Excipients in Multiple-Unit Particulate Systems
| Basic data | |
|---|---|
| OCA1. Surname awarded to the assessed person | Mučaji |
| OCA2. Name awarded to the assessed person | Pavel |
| OCA3. Degrees awarded to the assessed person | Prof. , Pharm.D., PhD |
| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/3753 |
| OCA5. Area of assessment | study programme pharmacy (joint study programme) · I. + II. degree |
| OCA6. Category of the research/artistic/other output | scientific output |
| OCA7. Year of publication of the research/artistic/other output | 2022 |
| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | ID: 503098 |
| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioForm&sid=25833FAFB5AACDA946F694FE13 |
| Characteristics of the output that is not registered in CRPA or CRAA | |
| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://www.scopus.com/pages/publications/85137268566?origin=resultslist |
| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | Papadakos Martina, Mučaji Pavel, Špaglová Miroslava, Čuchorová Mária, Macho Oliver: Chitosan and Sodium Alginate Implementation as Pharmaceutical Excipients in Multiple-Unit Particulate Systems |
| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | |
| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://www.mdpi.com/2073-4360/14/14/2822 |
| OCA14. Characteristics of the author's contribution | |
| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | |
| Other data | |
| OCA16. Annotation of the output in English | This study aimed to prepare and evaluate pellets containing acyclovir as a model drug. Pellets were prepared by the extrusion–spheronization process. Aqueous solutions of natural marine polymers (sodium alginate, chitosan) were compared to semi-synthetic hydroxypropyl methylcellulose (HPMC) in the role of binders. The study focused on the characterization of the pellet properties that are crucial for the formulation of the final dosage form, such as in multi-unit pellet system (MUPS) tablets or hard gelatin capsules filled with the pellets. Finally, the mentioned dosage forms were tested for drug dissolution. The morphology of pellets observed by scanning electron microscopy correlated with the shape evaluation performed by dynamic image analysis. Sodium alginate pellets exhibited the lowest value of sphericity (0.93), and many elongated rods and dumbbells were observed in this batch. Chitosan pellets had the highest value of sphericity (0.97) and were also less rough on the surface. The pellets maintained a constant surface geometry during the dissolution studies; they only reduced in size. The most significant reduction in size and weight was assessed after 2 h of dissolution testing. This fact was in line with the drug release from pellets in capsules or MUPS tablets, which was massive during the first hour, in both cases. The dissolution profiles of all of the batches were comparable. |
| OCA17. List of maximum 5 most significant citations corresponding to the output | 2024 [01/20] / CHE - Daulay, Amru - Astuti, Widi - Mufakhir, Fika Rofiek - Prasetia, Hendra - Samada, Lukmanul Hakim. Chitosan grafted alginate and polyvinylpyrrolidone as the binder for porous silicon nanoparticles from coal fly ash in lithium-ion batteries [elektronický dokument]. DOI 10.1016/j.jelechem.2023.117984 In: Journal of Electroanalytical Chemistry. Lausanne: Elsevier, 2024, Roč. 952, art. no. 117984, s. [1-11] [tlačená forma] [online]. ISSN 1572-6657. ISSN (online) 1873-2569. - SCO, s. [1 - 11] 2024 [01/20] / GBR - Chen, Jiaqi - Gao, Yanan - Zhang, Yanqiu - Wang, Mingxing. Research progress in the treatment of inflammatory bowel disease with natural polysaccharides and related structure-activity relationships [elektronický dokument]. DOI 10.1039/d3fo04919a In: Food & Function. Cambridge: The Royal Society of Chemistry, 2024, Roč. 15, č. 11, s. 5680-5702 [tlačená forma] [online]. ISSN 2042-6496. ISSN (online) 2042-650X. - SCO ; WOS CC ; SCIE, s. 5680 - 5702 2023 [01/20] / GBR - Armengol, Eva Sanchez - Knoll, Patrick - Hupfauf, Andrea - Gust, Ronald - Laffleur, Flavia. Chitosan-maleic acid conjugate as potential excipient candidate for oral drug delivery? [elektronický dokument]. DOI 10.4155/fmc-2022-0258 In: Future Medicinal Chemistry. Londýn: Future Medicine, 2023, Roč. 15, č. 3, s. 241-253 [tlačená forma] [online]. ISSN 1756-8919. ISSN (online) 1756-8927. - WOS CC ; SCO, s. 241 - 253 2023 [01/20] / GBR - Khalaf, Eman M. - Abood, Noor Adil - Atta, Raghad Z. - Ramirez-Coronel, Andres Alexis - Alazragi, Reem - Parra, Rosario Mireya Romero - Abed, Osama H. - Abosaooda, Munther - Jalil, Abduladheem Turki - Mustafa, Yasser Fakri - Narmani, Asghar - Farhood, Bagher. Recent progressions in biomedical and pharmaceutical applications of chitosan nanoparticles: A comprehensive review [elektronický dokument]. DOI 10.1016/j.ijbiomac.2023.123354 In: International Journal of Biological Macromolecules: Structure, Function and Interactions. Oxford: Elsevier, 2023, Roč. 231, s. [tlačená forma] [online]. ISSN 0141-8130. ISSN (online) 1879-0003. - WOS CC ; CCC ; SCO 2023 [01/20] / CHE - Žigrayova, Dominika - Mikušová, Veronika - Mikuš, Peter. Advances in Antiviral Delivery Systems and Chitosan-Based Polymeric and Nanoparticulate Antivirals and Antiviral Carriers [elektronický dokument]. DOI 10.3390/v15030647 In: Viruses. Bazilej: Multidisciplinary Digital Publishing Institute, 2023, Roč. 15, č. 3, art. no. 647, s. [1-56] [online]. ISSN (online) 1999-4915. - WOS CC ; SCO ; OA ; SCIE, s. [1 - 56] |
| OCA18. Characteristics of the output's impact on socio-economic practice | |
| OCA19. Characteristics of the output and related activities' impact on the educational process | |