HUNIADI, Mykhailo - NOSÁLOVÁ, Natália - HORŇÁKOVÁ, Ľubica - PETROUŠKOVÁ, Patrícia - KALINAJ, Blažej - MESAROŠOVÁ, Barbora - ČENTE, Martin - KUBATKA, Peter - HORŇÁK, Slavomír - ČÍŽKOVÁ, Dáša. Altered microRNA profiles and associated pathways in canine mammary adenocarcinoma. In: Scientific Reports. 2026. ISSN 2045-2322, Vol. 16, no. 1 (2026), art. no. 978, p. [1-11]

Basic data
OCA1. Surname awarded to the assessed person	Horňáková
OCA2. Name awarded to the assessed person	Ľubica
OCA3. Degrees awarded to the assessed person	Assoc. prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6074
OCA5. Area of assessment	study programme veterinary obstetrics and gynecology · III. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2026
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID = 1511439
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=AF3151A314B042018E97194AC3D9
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://arl4.library.sk/arl-uvlk/sk/detail-uvlk_un_cat-0047893-Altered-microRNA-profiles-and-associated-pathways-in-canine-mammary-adenocarcinoma/
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	HUNIADI, Mykhailo - NOSÁLOVÁ, Natália - HORŇÁKOVÁ, Ľubica - PETROUŠKOVÁ, Patrícia - KALINAJ, Blažej - MESAROŠOVÁ, Barbora - ČENTE, Martin - KUBATKA, Peter - HORŇÁK, Slavomír - ČÍŽKOVÁ, Dáša. Altered microRNA profiles and associated pathways in canine mammary adenocarcinoma. In: Scientific Reports. 2026. ISSN 2045-2322, Vol. 16, no. 1 (2026), art. no. 978, p. [1-11]
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.nature.com/articles/s41598-025-30579-0
OCA14. Characteristics of the author's contribution	The author had a significant influence on the creation and content of the publication. She significantly contributed to the acquisition and completion of biological material.
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	Canine mammary tumors (CMTs) are common in female dogs and represent a key model for studying human breast cancer (BC). Among the various subtypes of CMT, adenocarcinoma of the mammary gland (AMG) is one of the most prevalent and aggressive. In this study, we analyzed the expression of 84 microRNAs (miRNAs) in AMG and healthy mammary tissues using qRT-PCR. MiRNA profiling in canine AMG tissue revealed upregulation of miR-101, miR-106b, miR-143, miR-15a, miR-205, and miR-93, and downregulation of let-7c, miR-10b, miR-191, and miR-26a. Pathway enrichment linked these deregulated miRNAs to key oncogenic networks, demonstrating conserved molecular mechanisms shared with human BC and highlighting their potential as biomarkers in CMTs. These findings provide insights into the molecular mechanisms of CMT adenocarcinoma and suggest the potential of miRNA-based biomarkers for the diagnosis and treatment of CMTs.
Other data
OCA16. Annotation of the output in English	A key model for studying human breast cancer (BC) represents the canine model of mammary gland tumors (CMT) in bitches. Among the various subtypes of CMT, adenocarcinoma of the mammary gland (AMG) is one of the most prevalent and aggressive. We analyzed the expression of 84 microRNAs (miRNAs) in AMG and healthy mammary tissues using qRT-PCR. This exploratory study provides preliminary evidence that deregulated miRNAs may contribute to the molecular landscape of CMTs. The altered expression of miR-106b, miR-143, miR-93, let-7c, miR-191, and miR-26a suggests potential involvement in key oncogenic processes such as proliferation, angiogenesis, and epithelial–mesenchymal transition. These functional relationships highlight a potential translational bridge between mechanistic understanding and therapeutic application in human and veterinary oncology.
OCA17. List of maximum 5 most significant citations corresponding to the output
OCA18. Characteristics of the output's impact on socio-economic practice	The study of novel diagnostics and therapeutic approaches is essential for future research in both human and veterinary oncology, which is of great importance for socio-economic and economic practice.
OCA19. Characteristics of the output and related activities' impact on the educational process	The research findings offer new insights into the potential for diagnosing mammary gland tumours in veterinary medicine, which are utilised in the pedagogical process and subsequently applied in the clinical practice of small animals.